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Schistosoma japonicum infection modulates the development of allergen-induced airway inflammation in mice

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Abstract

Asthma, a chronic inflammatory disorder of the airways, is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. It has been shown that helminth infections including Schistosoma mansoni may modulate atopic diseases including asthma. In the present study, BALB/c mice were infected with bisexual and unisexual (male) S. japonicum, respectively, prior to ovalbumin (OVA) sensitization and challenge. Compared to mice with OVA sensitization/challenge alone, S. japonicum infection led to a significant decrease of eosinophil accumulation in bronchoalveolar lavage fluid (BALF) collected 48 h postchallenge, as well as to a marked reduction in inflammatory cell infiltration around the airways and pulmonary blood vessels. Compared to OVA-immunized uninfected mice, the level of OVA-specific serum IgE as well as interleukin (IL)-4 and IL-5 in BALF were reduced, but IL-10 was strongly elevated in mice with preexisting S. japonicum infection prior to OVA immunization. These results suggest that both bisexual and male S. japonicum infections may modulate the development of allergic asthma.

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Acknowledgments

We are grateful for the valuable discussion and critical revision of Prof. Andreas Ruppel from Heidelberg University, Heidelberg, Germany.

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Authors and Affiliations

  1. Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, People’s Republic of China

    Hong-mei Mo, Jia-hui Lei, Zi-wei Jiang, Cheng-zu Wang, Yu-li Cheng, Yong-long Li & Wen-qi Liu

  2. Department of Laboratory Medicine, People’s Hospital of Xinjiang Urgar Autonomous Region, Urumqi, People’s Republic of China

    Hong-mei Mo

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  1. Hong-mei Mo
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  2. Jia-hui Lei
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  4. Cheng-zu Wang
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  5. Yu-li Cheng
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  6. Yong-long Li
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Correspondence to Wen-qi Liu.

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Mo, Hm., Lei, Jh., Jiang, Zw. et al. Schistosoma japonicum infection modulates the development of allergen-induced airway inflammation in mice. Parasitol Res 103, 1183–1189 (2008). https://doi.org/10.1007/s00436-008-1114-1

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  • DOI: https://doi.org/10.1007/s00436-008-1114-1

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