Abstract
Moderately elevated homocysteine concentrations, reflecting deficiency of some nutritional factors required for homocysteine metabolism (folate, vitamin B-6, vitamin B-12) and/or less severe genetic defects, are common in the general population. Several studies have indicated the role of homocysteine as an independent risk factor for vascular disease. A pilot study published recently suggested that plasma homocysteine levels increase during weight reduction in slightly overweight, otherwise healthy subjects (group A). We examined a comparable group of 13 overweight subjects (group B) using a standardised caloric intake and defined vitamin supplementation (Medyn: folate 0.2 mg/ vitamin B-6 8.0 mg/ vitamin B-12 0.010 mg three times the day orally) to determine the effect of weight reduction on serum homocysteine levels and to compare the results with those of the pilot study. Mean body weight declined from 87.0±20.2 to 84.2±20.1 kg (P<0.05) in group A and 85.7±11.3 to 82.5±9.9 kg (P=0.049) in group B. Serum homocysteine levels rosed from 7.9±2.0 to 8.7±2.3 ìmol/l (P<0.0001) in group A and decreased from 8.19±1.73 to 7.35±0.88 ìmol/l (P=0.0022) in group B. No correlation was found between the changes in body weight and in homocysteine levels (r=0.02 in group A, r=0.18 in group B). Additionally, no correlation was found between serum folate levels and changes in homocysteine levels (r=0.03 in group A, r=0.09 in group B). The results suggest that an adequate oral vitamin-supplementation protects against increased homocysteine production during weight reduction.
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References
Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 274: 1049-1057
Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG (1995) Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 346:1395-1398
McCully KS (1996) Homocysteine and vascular disease. Nat Med 2:386-389
Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270:2693-2698
Bray GA (1985) Complications of obesitas. Ann Intern Med 103:1052-1062
Henning BF, Tepel M, Riezler R, Doberauer C (1997) Unfavourable changes in homocysteine metabolism during weight reduction. Med Sci Res 25:555-556
Stabler SP, Marcell PD, Podell ER, Allen RH (1987) Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 162:185-196
Stabler SP, Lindenbaum J, Savage DG, Allen RH (1993) Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood 81:3404-3413
Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH (1993) Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem 39:1764-1779
Joosten E, Berg A van den, Riezler R, Naurath HJ, Lindenbaum J, Stabler SP, Allen RH (1993) Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 58:468-476
Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I (1991) Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 324:1149-1155
National Research Council (1989): Diet and health. Implications for reducing chronic disease risk. National Academy Press, Washington
Wechsler JG (1995) Therapie der Adipositas. Internist 36:1063-1069
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Henning, B.F., Tepel, M., Riezler, R. et al. Vitamin supplementation during weight reduction — favourable effect on homocysteine metabolism. Res. Exp. Med. 198, 37–42 (1998). https://doi.org/10.1007/s004330050087
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DOI: https://doi.org/10.1007/s004330050087