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Vascular endothelial growth factor and endoglin expression in colorectal cancer

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Abstract

Purpose and methods

Vascular endothelial growth factor (VEGF) overexpression has been associated with advanced stage and poor survival in several cancers. Additionally, endoglin was proposed as a marker of neovascularization in solid malignancies. The aim of this study was to evaluate the association between the VEGF and endoglin expression in colorectal carcinoma patients, as well as to correlate the VEGF and endoglin expression with standard parameters, to define their potential prognostic role. VEGF and endoglin expression were evaluated in 99 unrelated patients with colorectal cancer using immunohistochemistry.

Results

Vascular endothelial growth factor and endoglobin expression were positively interrelated. No significant correlation of VEGF and endoglin expression with clinicopathological parameters was observed in our cases. The Kaplan–Meier survival curves have demonstrated a clear association of cancer-specific overall survival with high VEGF, as well as high endoglin expression.

Conclusion

Our results support that VEGF and endoglin act as two valuable indicators of prognosis.

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Acknowledgments

The project was co-funded by the European Social Fund and National Resources, (EPEAEKII) PYTHAGORAS.

Conflict of interest statement

None.

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Authors and Affiliations

  1. First Surgical Department, “Tzaneion” Hospital, Piraeus, Greece

    Konstantinos Dassoulas & Spyros Rizos

  2. Department of Biology, School of Medicine, University of Athens, Michalakopoulou 176, Goudi, 11527, Athens, Greece

    Maria Gazouli & Theodoros Karantanos

  3. 1st Propaideutic Surgical Department, Hippocration University Hospital, Athens, Greece

    George Theodoropoulos

  4. Department of Cytopathology, University General Hospital “Attikon”, Athens, Greece

    Zoi Christoni & Petros Karakitsos

  5. Department of Pathology-Anatomy, “Tzaneion” Hospital, Piraeus, Greece

    Adamantia Zisi-Serbetzoglou & Chrissa Glava

  6. First Surgical Department, “Laikon” University Hospital, University of Athens, Athens, Greece

    Christos Klonaris

Authors
  1. Konstantinos Dassoulas
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  2. Maria Gazouli
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  3. George Theodoropoulos
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  4. Zoi Christoni
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  5. Spyros Rizos
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  6. Adamantia Zisi-Serbetzoglou
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  7. Chrissa Glava
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  8. Theodoros Karantanos
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  9. Christos Klonaris
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  10. Petros Karakitsos
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Corresponding author

Correspondence to Maria Gazouli.

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Dassoulas, K., Gazouli, M., Theodoropoulos, G. et al. Vascular endothelial growth factor and endoglin expression in colorectal cancer. J Cancer Res Clin Oncol 136, 703–708 (2010). https://doi.org/10.1007/s00432-009-0709-y

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  • DOI: https://doi.org/10.1007/s00432-009-0709-y

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