Abstract
Purpose
To evaluate the association between glutathione S-transferase Omega (GSTO) genes polymorphism and the susceptibility of acute lymphoblast leukemia (ALL).
Methods
The polymorphism of GSTO1 and GSTO2 genes were analyzed in 99 ALL patients compared with 100 healthy children by PCR-based restriction fragment length polymorphism (RFLP) analysis.
Results
GSTO1*A140D polymorphism was significantly associated with susceptibility to ALL (OR = 2.24, 95% CI = 1.16–4.35, P = 0.009) whereas, GSTO2*N142D genotype was significantly interacted with high risk group of childhood ALL (OR = 5.52, 95% CI = 1.72–17.71, P = 0.004).
Conclusion
This study revealed gene polymorphism in glutathione S-transferase Omega class may be a risk factor to the development of acute childhood lymphoblastic leukemia.
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Acknowledgments
This work was supported by Rangsit University and the Faculty of Tropical Medicine, Mahidol University. We thank Dr. Tanette Pakeetoot, Department of Biochemistry, Faculty of Science, Rangsit University and Dr. Acharawan Thongmee, Faculty of Medical Technology, Rangsit University for their technical assistance and Mr. Paul Adams for reading of the manuscript.
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Pongstaporn, W., Pakakasama, S., Sanguansin, S. et al. Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia. J Cancer Res Clin Oncol 135, 673–678 (2009). https://doi.org/10.1007/s00432-008-0501-4
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DOI: https://doi.org/10.1007/s00432-008-0501-4