Skip to main content
Log in

Patients with different or identical genotypes of the WT1 gene present different phenotypes

  • Correspondence
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Benoit G, Machuca E, Antignac C (2010) Hereditary nephrotic syndrome: a systematic approach for genetic testing and a review of associated podocyte gene mutations. Pediatr Nephrol 25:1621–1632

    Google Scholar 

  2. Chernin G, Vega-Warner V, Schoeb DS, Heeringa SF, Ovunc B, Saisawat P, Cleper R, Ozaltin F, Hildebrandt F, Members of the GPN Study Group (2010) Genotype/phenotype correlation in nephrotic syndrome caused by WT1 mutations. Clin J Am Soc Nephrol 5:1655–1662

    Google Scholar 

  3. Fencl F, Malina M, Stará V, Zieg J, Mixová D, Seeman T, Bláhová K (2012) Discordant expression of a new WT1 gene mutation in a family with monozygotic twins presenting with congenital nephrotic syndrome. Eur J Pediatr 171:121–124

    Article  PubMed  Google Scholar 

  4. Hakan N, Aydin M, Erdogan O, Cavusoglu YH, Aycan Z, Ozaltin F, Zenciroglu A, Apaydin S, Gunes R, Sahin G, Cinar G, Okumus N (2012) A novel WT1 gene mutation in a newborn infant diagnosed with Denys–Drash syndrome. Genet Couns 23:255–261

    PubMed  CAS  Google Scholar 

  5. Mueller RF (1994) The Denys–Drash syndrome. J Med Genet 31:471–477

    Article  PubMed  CAS  Google Scholar 

  6. Takata A, Kikuchi H, Fukuzawa R, Ito S, Honda M, Hata J (2000) Constitutional WT1 mutations correlate with clinical features in children with progressive nephropathy. J Med Genet 37:698–701

    Article  PubMed  CAS  Google Scholar 

  7. Yang Y, Feng D, Huang J, Nie X, Yu Z (2013) A child with isolated nephrotic syndrome and WT1 mutation presenting as a 46, XY phenotypic male. Eur J Pediatr 172:127–129

    Article  PubMed  Google Scholar 

  8. Yu Z, Yang Y, Feng D (2012) Discordant phenotypes in monozygotic twins with identical de novo WT1 mutation. Clin Kidney J 5:221–222

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zihua Yu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, Y., Zhao, F., Huang, J. et al. Patients with different or identical genotypes of the WT1 gene present different phenotypes. Eur J Pediatr 172, 1707–1708 (2013). https://doi.org/10.1007/s00431-013-2086-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00431-013-2086-4

Keywords

Navigation