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Principles of polyoma- and papillomavirus uncoating

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Abstract

Virus particles are vehicles for transmission of the viral genetic information between infected and uninfected cells and organisms. They have evolved to self-assemble, to serve as a protective shell for the viral genome during transfer, and to disassemble when entering a target cell. Disassembly during entry is a complex, multi-step process typically termed uncoating. Uncoating is triggered by multiple host-cell interactions. During cell entry, these interactions occur sequentially in different cellular compartments that the viruses pass through on their way to the site of replication. Here, we highlight the general principles of uncoating for two structurally related virus families, the polyoma- and papillomaviruses. Recent research indicates the use of different compartments and cellular interactions for uncoating despite their structural similarity.

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Acknowledgments

The authors would like to acknowledge the help of Dr. R. Mancini in acquisition of electron micrographs. We apologize to all those great individuals who have advanced the field of polyoma- and papillomavirus structure and entry, and who were not mentioned in the manuscript due to space limitations. MS and CC were supported by the German Science Foundation (DFG, Emmy-Noether grant SCHE 1552/2-1) and by the Portuguese Foundation for Science and Technology (PhD grant SFRH/BD/45921/2008), respectively.

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  1. Emmy-Noether Group ‘Virus Endocytosis’, Institutes of Molecular Virology and Medical Biochemistry, University of Münster, Münster, Germany

    Carla Cerqueira & Mario Schelhaas

  2. ZMBE, Institutes for Medical Biochemistry and Molecular Virology, University of Münster, Von-Esmarch-Str. 56, 48149, Münster, Germany

    Mario Schelhaas

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  1. Carla Cerqueira
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  2. Mario Schelhaas
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Correspondence to Mario Schelhaas.

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Cerqueira, C., Schelhaas, M. Principles of polyoma- and papillomavirus uncoating. Med Microbiol Immunol 201, 427–436 (2012). https://doi.org/10.1007/s00430-012-0262-1

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