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Maternal sensitivity predicts anterior hippocampal functional networks in early childhood

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Abstract

Maternal care influences child hippocampal development. The hippocampus is functionally organized along an anterior–posterior axis. Little is known with regards to the extent maternal care shapes offspring anterior and posterior hippocampal (aHPC, pHPC) functional networks. This study examined maternal behavior, especially maternal sensitivity, at 6 months postpartum in relation to aHPC and pHPC functional networks of children at age 4 and 6 years. Maternal sensitivity was assessed at 6 months via the “Maternal Behavior Q Sort (MBQS) mini for video”. Subsequently, 61 and 76 children underwent resting-state functional magnetic resonance imaging (rs-fMRI), respectively, at 4 and 6 years of age. We found that maternal sensitivity assessed at 6 months postpartum was associated with the right aHPC functional networks in children at both 4 and 6 years of age. At age 4 years, maternal sensitivity was associated positively with the right aHPC’s functional connectivity with the sensorimotor network and negatively with the aHPC’s functional connectivity with the top–down cognitive control network. At 6 years of age, maternal sensitivity was linked positively with the right aHPC’s functional connectivity with the visual-processing network. Our findings suggested that maternal sensitivity in infancy has a long-term impact on the anterior hippocampal functional network in preschool children, implicating a potential role of maternal care in shaping child brain development in early life.

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Funding

This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore- NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore Ministry of Education (Academic research fund tier 1; NUHSRO/2017/052/T1-SRP-Partnership/01), and NUS Institute of Data Science, Singapore.

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Authors and Affiliations

  1. Department of Biomedical Engineering and Clinical Imaging Research Center, National University of Singapore, 4 Engineering Drive 3 Block E4 #04-08, Singapore, 117583, Singapore

    Qiang Wang, Han Zhang, Chong-Yaw Wee, Annie Lee, Joann S. Poh & Anqi Qiu

  2. Singapore Institute for Clinical Sciences, Singapore, 117609, Singapore

    Yap-Seng Chong & Peter D. Gluckman

  3. Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore

    Yap-Seng Chong

  4. Department of Maternal–Fetal Medicine, KK Women’s and Children’s Hospital, Singapore (KKH), Singapore, 229899, Singapore

    Kok Hian Tan

  5. Liggins Institute, University of Auckland, Auckland, 1142, New Zealand

    Peter D. Gluckman

  6. Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore (KKH), Singapore, 229899, Singapore

    Marielle V. Fortier

  7. Office of Education Research, Centre for Research in Child Development, Office of Education Research, National Institute of Education, Nanyang Technical University, Singapore, Singapore

    Anne Rifkin-Graboi

  8. Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, 229899, Singapore

    Fabian Yap

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  1. Qiang Wang
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Wang, Q., Zhang, H., Wee, CY. et al. Maternal sensitivity predicts anterior hippocampal functional networks in early childhood. Brain Struct Funct 224, 1885–1895 (2019). https://doi.org/10.1007/s00429-019-01882-0

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