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Lymphomas with plasmablastic features: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology

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A REVIEW AND PERSPECTIVES to this article was published on 02 August 2023

A REVIEW AND PERSPECTIVES to this article was published on 02 August 2023

A REVIEW AND PERSPECTIVES to this article was published on 02 August 2023

Abstract

Lymphomas with plasmablastic features are a heterogeneous group of aggressive and mostly uncommon neoplasms of varied aetiologies, presenting in immunocompetent individuals as well as in immunodeficiency, associated with EBV and Kaposi sarcoma virus infections, and some as progression from indolent B-cell lymphomas. They show overlapping diagnostic features and pose a differential diagnosis with other aggressive B-cell lymphomas that can downregulate the B-cell expression programme. The spectrum of rare reactive proliferations and all lymphomas defined by plasmablastic features, together with an expanding range of poorly characterised, uncommon conditions at the interface between reactive lymphoid proliferations and neoplasia submitted to the session V of the 20th European Association for Haematopathology/Society for Hematopathology lymphoma workshop are summarised and discussed in this paper.

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Acknowledgements

We thank Professor Lorenzo Leoncini and Dr. Lucia Mundo for their help with RNAscope analyses and Dr. Matt Pugh and Ms. Annemarie Moul for assistance with immunostaining. The authors gratefully acknowledge the case submitters for contributing materials and information for the cases in this session and for use of images in this review.

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Authors and Affiliations

  1. Department of Pathology and Cytology, University Hospital Centre Zagreb, University of Zagreb Medical School, Zagreb, Croatia

    Snjezana Dotlic

  2. Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ, USA

    Sarah E. Gibson

  3. Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt Am Main, Frankfurt Am Main, Germany

    Sylvia Hartmann

  4. Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, USA

    Eric D. Hsi

  5. Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital Huddinge, Stockholm, Sweden

    Monika Klimkowska

  6. Pathology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain

    Socorro Maria Rodriguez-Pinilla

  7. Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy

    Elena Sabattini

  8. Department of Imaging and Pathology and Translational Cell and Tissue Research Laboratory, Louvain, Belgium

    Thomas A. Tousseyn

  9. Department of Pathology, Amsterdam UMC, Location VUMC, Amsterdam, The Netherlands

    Daphne de Jong

  10. Department of Pathology, Morriston Hospital, Swansea Bay University Health Board/Swansea University, Swansea, UK

    Stefan Dojcinov

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  1. Snjezana Dotlic
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Contributions

S. Dotlic and S. Dojcinov chaired the WS session/performed all case reviews and wrote and edited the manuscript; all authors were members of the EA4HP/SH Workshop Panel, performed the case reviews, contributed to the study conception and design, and commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Stefan Dojcinov.

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All authors declare strict compliance with ethical standards. Any additional studies were conducted with the approval of the Medical Ethical Committee of AmsterdamUMC/VUMC (registration 2020.343).

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The authors declare no competing interests.

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Dotlic, S., Gibson, S.E., Hartmann, S. et al. Lymphomas with plasmablastic features: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology. Virchows Arch 483, 591–609 (2023). https://doi.org/10.1007/s00428-023-03585-8

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  • DOI: https://doi.org/10.1007/s00428-023-03585-8

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