Abstract
We report the first patient (a 13-year-old girl) with a sinonasal low-grade non-intestinal-type adenocarcinoma showing aberrant CDX2 expression both within morular areas and in the tubular component and demonstrate for the first time a SYN2-PPARG gene fusion in this tumor type. The tumor arose from the nasal septum and had not spread beyond the nasal cavity.
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Dr. Soon wrote the manuscript; Dr. Chang and Mr. Kuick conducted the molecular analysis; and Dr. Petersson reviewed the specimen, made the diagnosis, is responsible for the light microscopical and immunohistochemical pictures, and edited and revised the manuscript. All authors gave final their approval for publication.
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Soon, G.S.T., Chang, K.T.E., Kuick, C.H. et al. A case of nasal low-grade non-intestinal-type adenocarcinoma with aberrant CDX2 expression and a novel SYN2-PPARG gene fusion in a 13-year-old girl. Virchows Arch 474, 619–623 (2019). https://doi.org/10.1007/s00428-019-02524-w
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DOI: https://doi.org/10.1007/s00428-019-02524-w