Abstract
Voltage-dependent facilitation of L-type Ca2+ channels is an important regulatory mechanism by which excitable cells modulate Ca2+ entry during a train of action potentials. Expression of the α1 and β subunits of the α1C Ca2+ channel is necessary and sufficient to reproduce this kind of facilitation in Xenopus oocytes. Here we show that, by expressing the α1C together with different β subunits in oocytes, the β1, β3 and β4, but not the β2 subunits are permissive for Ca2+ channel facilitation. The poor facilitation observed in rat ventricular cells, together with the presence of the β2 subunit mRNA, suggest that β2 may be the β subunit associated with functional cardiac L-type Ca2+ channels.
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Received: 10 July 1995 /28 September 1995 /25 September 1995
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Cens, T., Mangoni, M., Richard, S. et al. Coexpression of the β2 subunit does not induce voltage-dependent facilitation of the class C L-type Ca channel. Pfluegers Arch 431, 771–774 (1996). https://doi.org/10.1007/s004240050064
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DOI: https://doi.org/10.1007/s004240050064