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Myeloid cells pave the way for lymphatic system development and maintenance

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Abstract

The maintenance of tissue homeostasis is indispensable for health. In particular, removal of toxic compounds from cells and organs is a vital process for the organism. The lymphatic vasculature works in order to ensure the efficient removal of tissue waste. Forbidden over the last decade when more attention was paid to the blood vasculature, studies on the lymphatic vasculature have gained momentum during the last couple of years. The lymphatic vasculature naturally runs parallel to the blood vasculature and their synergistic work is critical for maintaining tissue homeostasis. Diminished lymphatic function results in accumulation of body fluids in tissues and gives rise to edema. Recently, it became obvious that immune cells including myeloid cells and lymphocytes are able to interact with and control the development and function of the lymphatic vasculature. In this review, we will focus on the interaction between myeloid cells, including macrophages, monocytes, and dendritic cells, with lymphatic vessels.

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Abbreviations

BATF3:

Basic leucine zipper ATF-like transcription factor 3

Csf1r:

Colony stimulating factor 1 receptor

DC:

Dendritic cells

GATA6:

GATA binding protein 6

IRF4:

Interferon regulatory factor 4

IL:

Interleukin

LN:

Lymph node

LPS:

Lipopolysaccharide

LTA:

Lipoteichoic acid

Lyve1:

Lymphatic vessel endothelial hyaluronan receptor 1

M-CSF:

Macrophage colony-stimulating factor

PAT:

Perinodal adipose tissue

Prox1:

Prospero homeobox 1

TonEBP:

Tonicity-responsive enhancer-binding protein

Vegfr3:

Vascular endothelial growth factor receptor 3

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  1. Institut National de la Santé et de la Recherche Médicale (INSERM) U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), 06204, Nice, France

    Stoyan Ivanov

  2. Université de Nice Sophia-Antipolis, 06000, Nice, France

    Stoyan Ivanov

  3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Gwendalyn J. Randolph

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This article is published as part of the Special Issue on Macrophages in tissue homeostasis in Pflügers Archiv – European Journal of Physiology

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Ivanov, S., Randolph, G.J. Myeloid cells pave the way for lymphatic system development and maintenance. Pflugers Arch - Eur J Physiol 469, 465–472 (2017). https://doi.org/10.1007/s00424-017-1951-9

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