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Disentangling the molecular mechanisms of action of endogenous and environmental estrogens

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Abstract

The gonadal hormone 17β-estradiol is involved in numerous cellular processes. In many cases, 17β-estradiol actions are imitated by synthetic and natural chemicals in the environment. Their actions differ depending on the target tissue, the receptors involved and the molecular pathways activated. The plethora of estrogenic actions is triggered by different receptors and other specific structures that activate different signalling pathways. This amount of information may lead to a maze of effects triggered by endogenous and environmental estrogens that we intend to clarify in this review. Understanding the variety of estrogen receptors, their different locations and the signalling pathways activated by estrogenic ligands is fundamental for understanding the diversity of actions that estrogens have in different tissues and cells.

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Acknowledgements

The authors’ laboratory is funded by grants from Instituto de Salud Carlos III RCMN (C03/08) and (03/0178), and Ministerio de Educación y Ciencia (BFI2002-01469). PAM has a studentship from Ministerio de Educación y Ciencia. We thank Dr. Mario Díaz for helpful comments.

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  1. Institute of Bioengineering, School of Medicine, Miguel Hernández University, Sant Joan Campus, Carretera Alicante-Valencia Km 87, 03550, Alicante, Spain

    Angel Nadal, Paloma Alonso-Magdalena, Cristina Ripoll & Esther Fuentes

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  1. Angel Nadal
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  2. Paloma Alonso-Magdalena
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  4. Esther Fuentes
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Correspondence to Angel Nadal.

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Nadal, A., Alonso-Magdalena, P., Ripoll, C. et al. Disentangling the molecular mechanisms of action of endogenous and environmental estrogens. Pflugers Arch - Eur J Physiol 449, 335–343 (2005). https://doi.org/10.1007/s00424-004-1343-9

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