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Short-term outcomes of colorectal cancer surgery in patients with dialysis: a systematic review and meta-analysis

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Abstract

Purpose

This systematic review and meta-analysis aimed to evaluate the effect of dialysis-dependent chronic kidney disease (CKD) on postoperative complications in colorectal cancer surgery.

Methods

In April 2023, we systematically searched PubMed, the Cochrane library, and Ovid for relevant studies on short-term outcomes of colorectal cancer surgery in patients with dialysis and analyzed the findings from these studies for meta-analysis.

Results

Our systematic and meta-analysis review identified seven studies involving 50713 patients. We showed that the dialysis group had higher rates of mortality (OR = 4.12, 95%CI: 2.75–6.20, P < 0.001), cardiac complications (OR = 2.45, 95%CI: 1.88–3.21, P < 0.001), and pneumonia (OR = 2.68, 95%CI: 1.83–3.93, P < 0.001). On the other hand, there were no differences in superficial/deep surgical site infection (SSI) (odds ratio [OR] = 1.17, 95%CI: 0.90–1.53, P = 0.230) and organ/space SSI (OR = 1.35, 95%CI: 1.00–1.82, P = 0.053) between the dialysis group and non-dialysis group.

Conclusion

Our meta-analysis showed that dialysis-dependent CKD was associated with higher rates of mortality, cardiac complications, and pneumonia after colorectal cancer surgery. However, the limitations of this meta-analysis should be taken into consideration when interpreting the results.

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Authors and Affiliations

  1. Department of Surgery, Tokyo General Hospital, 3-15-2, Ekoda, Nakano, Tokyo, 165-8906, Japan

    Yasuhiro Takano, Wataru Kai, Yasunobu Kobayashi, Hironori Kanno & Nobuyoshi Hanyu

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  1. Yasuhiro Takano
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  2. Wataru Kai
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  3. Yasunobu Kobayashi
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  5. Nobuyoshi Hanyu
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Contributions

Each author contributed significantly to the concept and development of the present paper. YT and NH designed the research process. YT and WK searched the database for corresponding articles. YK and HK extracted useful information from the articles above. YT used statistical software for analysis. YT and NH drafted the meta-analysis. All authors had read and approved the manuscript and ensured that this was the case.

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Correspondence to Yasuhiro Takano.

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Takano, Y., Kai, W., Kobayashi, Y. et al. Short-term outcomes of colorectal cancer surgery in patients with dialysis: a systematic review and meta-analysis. Langenbecks Arch Surg 408, 283 (2023). https://doi.org/10.1007/s00423-023-03016-x

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