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Prolonged door-to-antibiotics time is associated with high hospital mortality in patients with perforated colorectal peritonitis

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Abstract

Purpose

Colorectal perforation is a fatal disease that presents with generalized peritonitis, leading to sepsis and septic shock. Recently, the association between prolonged door-to-antibiotics time and increased mortality in sepsis has been widely reported. In this study, we investigated the prognostic impact of a prolonged door-to-antibiotics time in patients with perforated colorectal peritonitis undergoing emergency surgery.

Methods

This retrospective study included 93 patients with perforated colorectal peritonitis who underwent emergency surgery at our institution between April 2015 and August 2019. Patients were divided into two groups depending on the door-to-antibiotics time (< 162 min or ≥ 162 min). The primary outcome was in-hospital mortality. The secondary outcomes were the length of hospital stay and severe complication rate. The logistic regression analysis was used to estimate the odds ratio for in-hospital mortality.

Results

We identified 38 patients who presented with an extended door-to-antibiotics time (≥ 162 min) and 55 patients who presented with a shortened door-to-antibiotics time (< 162 min). We found a strong association between the door-to-antibiotics time ≥ 162 min and in-hospital mortality. There were no significant differences between the two groups regarding the length of hospital stay and postoperative complication rate. However, in multivariate analysis, extended door-to-antibiotics time was an independent prognostic factor for in-hospital mortality (odds ratio = 244; 95% confidence interval, 11 –23,885).

Conclusion

A prolonged door-to-antibiotics time (≥ 162 min) worsened hospital mortality rates in patients with perforated colorectal peritonitis.

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Acknowledgements

We would like to thank Editage for English language editing.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Life Science, Kumamoto University, 1-1-1 Honjo, Chuo-Ku, Kumamoto, 860-8556, Japan

    Katsuhiro Ogawa, Yuta Shiraishi, Hidetoshi Nitta, Hiroshi Sawayama, Yuji Miyamoto & Hideo Baba

  2. Division of Surgery, Saiseikai Kumamoto Hospital, Kumamoto, Japan

    Ryuichi Karashima

  3. Division of Surgery, Kumamoto Regional Medical Center, Kumamoto, Japan

    Toshiro Masuda

  4. Division of Surgery, Kumamoto Medical Center, Kumamoto, Japan

    Katsutaka Matsumoto

  5. Taragi Municipal Hospital, Taragi, Japan

    Hiroshi Takamori

Authors
  1. Katsuhiro Ogawa
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  2. Yuta Shiraishi
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Contributions

K.O. and H.T. wrote the main manuscript text. They prepared Fig. 1. All authors reviewed the manuscript.

Corresponding author

Correspondence to Katsuhiro Ogawa.

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Ethics approval

The protocol for this retrospective research has been approved by a suitably constituted Ethics Committee of Saiseikai Kumamoto Hospital, and it conforms to the provisions of the Declaration of Helsinki and the Ethics Committee of Saiseikai Kumamoto hospital (Kumamoto, Japan).

Informed consent

Because this was a retrospective review of medical records, the consent to participate was not required from the patients.

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None declared.

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Ogawa, K., Shiraishi, Y., Karashima, R. et al. Prolonged door-to-antibiotics time is associated with high hospital mortality in patients with perforated colorectal peritonitis. Langenbecks Arch Surg 408, 220 (2023). https://doi.org/10.1007/s00423-023-02966-6

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