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Upper transversal hepatectomy with double hepatic vein resection and reconstruction to treat colorectal cancer liver metastases at the hepatocaval confluence: a strategy to achieve R0 liver-sparing resection

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Abstract

Background

Repeated hepatectomies in the therapeutic route of patients with colorectal liver metastases (CRLM) may improve their long term survival. Hepatic vein (HV) resection and reconstruction allows parenchyma-sparing hepatectomy (PSH) and R0 resections for CRLM in contact with one HV. We aimed at verifying the feasibility of PSH with double HV resection and direct reconstruction for CRLM in contact with two HVs at the hepatocaval confluence.

Methods

Out of 106 consecutive PSH performed for CRLM deep-located in segments I-IVa-VII-VIII, four (3.7%) PSH were performed with resection of CRLM en bloc with two adjacent HVs which were both reconstructed with double direct HV anastomosis: 3 cases between right-HV and middle-HV and 1 case between middle-HV and left-HV. Two patients had previously undergone liver resection. Three patients had one single lesion and one had 5 CRLMs.

Results

Median size of CRLMs in contact with HVs was 25 mm (range 22–30 mm). At histological examination, all resections were R0 except one R1-vascular (detachment from glissonean pedicle): in all cases at least one HV and in 1 case both HVs were infiltrated by the tumor cells. After median follow-up of 18 (range 3.5–41.2) months, all HVs were patent. All patients were alive and in good general conditions, and 3 patients were disease free (one of them following a liver re-resection). One patient experienced a grade IIIa complication. Median hospital-stay was 11 (range 9–13) days.

Conclusion

In patients with CRLMs involving two adjacent HVs at the hepatocaval confluence, liver resection with double HV resection and direct reconstruction is feasible and may be considered to guarantee oncological radicality (R0) and spare health parenchyma.

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Acknowledgements

The authors are indebted to Luca Viganò for his critical revision of the manuscript and to Francesco Carbone for the histological analysis of the case reported in Fig. 4.

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Authors and Affiliations

  1. General Surgery Unit, Azienda Ospedaliero-Universitaria PisanaOspedale Nuovo Santa Chiara, Cisanello, Via Paradisa, 2, 56124, Pisa, Italy

    Lucio Urbani, Nicolò Roffi, Stefano Signori, Riccardo Balestri, Piero Buccianti & Marco Puccini

  2. Hepatology Unit, Azienda Ospedaliero-Universitaria PisanaOspedale Nuovo Santa Chiara, Cisanello, Via Paradisa, 2, 56124, Pisa, Italy

    Piero Colombatto

  3. Anaesthesiology and Intensive Care Unit, Azienda Ospedaliero-Universitaria PisanaOspedale Nuovo Santa Chiara, Cisanello, Via Paradisa, 2, 56124, Pisa, Italy

    Gabriella Licitra, Chiara Leoni & Daniele Meiattini

  4. Oncology Unit, Azienda Ospedaliero-Universitaria PisanaOspedale Nuovo Santa Chiara, Cisanello, Via Paradisa, 2, 56124, Pisa, Italy

    Roberto Moretto, Chiara Cremolini & Gianluca Masi

  5. Radiology Unit, Azienda Ospedaliero-Universitaria PisanaOspedale Nuovo Santa Chiara, Cisanello, Via Paradisa, 2, 56124, Pisa, Italy

    Piero Boraschi

  6. Pathology Unit, Azienda Ospedaliero-Universitaria PisanaOspedale Nuovo Santa Chiara, Cisanello, Via Paradisa, 2, 56124, Pisa, Italy

    Francesca Quilici

Authors
  1. Lucio Urbani
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  2. Nicolò Roffi
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  9. Roberto Moretto
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Corresponding author

Correspondence to Lucio Urbani.

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Urbani, L., Roffi, N., Signori, S. et al. Upper transversal hepatectomy with double hepatic vein resection and reconstruction to treat colorectal cancer liver metastases at the hepatocaval confluence: a strategy to achieve R0 liver-sparing resection. Langenbecks Arch Surg 407, 1741–1750 (2022). https://doi.org/10.1007/s00423-021-02409-0

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