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The prognostic value of combined tumor markers and systemic immune-inflammation index in colorectal cancer patients

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Abstract

Purpose

This study evaluated the significance of combining tumor markers (TM) and systemic immune-inflammation index (SII) for postoperative complications and long-term outcomes in colorectal cancer (CRC) patients.

Methods

CRC patients (662) who underwent surgery between 2012 and 2014 were retrospectively enrolled into our study. Factors affecting postoperative complications were evaluated by logistic regression analysis. Prognostic factors were assessed using Kaplan-Meier and Cox proportional hazards models. Nomograms were constructed to predict the risk of postoperative complications and survival. A consistency index and a calibration curve were used to evaluate the predictive accuracy of nomograms.

Results

TM-SII score was established by combining TM and SII. Logistic regression analyses showed that TM-SII score was an important predictor of postoperative complications in CRC patients. Kaplan-Meier analyses showed that TM-SII score was favorable for prognostic risk stratification. In addition, multivariate analyses indicated that TM-SII score was an independent prognostic indicator for disease-free survival and overall survival. TM-SII based nomograms had a moderate prediction accuracy.

Conclusion

TM-SII score is a good prognostic indicator for CRC patients. It may be used as a useful risk stratification tool for advanced CRC patients. TM-SII-based nomograms could be used to identify CRC patients with poor outcomes.

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Author information

Authors and Affiliations

  1. Department of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi, People’s Republic of China

    Hailun Xie, Guanghui Yuan, Shizhen Huang, Jiaan Kuang, Ling Yan, Guotian Ruan & Jialiang Gan

  2. Deparment of Pharmacy, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China

    Shuangyi Tang

Authors
  1. Hailun Xie
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  2. Guanghui Yuan
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  3. Shizhen Huang
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  4. Jiaan Kuang
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  5. Ling Yan
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  6. Guotian Ruan
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  7. Shuangyi Tang
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  8. Jialiang Gan
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Contributions

This study was designed by Jialiang Gan and Hailun Xie. Hailun Xie and Guanghui Yuan performed statistical analyses. The clinical information and materials were collected and kept by Guanghui Yuan, Shizhen Huang, Jiaan Kuang, Ling Yan, Guotian Ruan, and Shuangyi Tang. Hailun Xie drafted the manuscript. Jialiang Gan edited and revised the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Jialiang Gan.

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The authors declare that they have no conflicts of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Xie, H., Yuan, G., Huang, S. et al. The prognostic value of combined tumor markers and systemic immune-inflammation index in colorectal cancer patients. Langenbecks Arch Surg 405, 1119–1130 (2020). https://doi.org/10.1007/s00423-020-01963-3

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  • DOI: https://doi.org/10.1007/s00423-020-01963-3

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