Abstract
Purpose
To examine the effect of high-intensity interval work (HIIW) and moderate-intensity continuous work (MICW) on markers of acute kidney injury (AKI) and kidney function in a hot environment.
Methods
Nine males completed 2 h of work (2 × 60 min with 10 min passive rest) in a hot environment (40 °C and 15% relative humidity) as either HIIW [2 min at 80% peak oxygen consumption (VO2peak) and 3 min at 30% VO2peak] or MICW (matched for total work of HIIW). Blood and urine samples were collected immediately before (Pre), after (Post), 1 h (1 h Post), and 24 h after (24 h Post) the trials. Urine flow rate (UFR), creatinine clearance, insulin-like growth factor binding protein 7 (IGFBP7), urinary neutrophil gelatinase-associated lipocalin (uNGAL), and urinary kidney injury marker 1 (uKIM-1) were measured to assess kidney function and injury.
Results
Log IGFBP7 (p < 0.01), log uNGAL (p < 0.01), and log uKIM-1 (p = 0.01) all displayed a main effect for time after both HIIW and MICW. IGFBP7 (p = 0.01) and uKIM-1 (p < 0.01), corrected for Uosm, were higher after HIIW compared to MICW at Post, while IGFBP7 was also higher 1 h Post after HIIW compared to MICW (p = 0.02). UFR significantly decreasing from Pre to Post (p < 0.01) and 1 h Post (p < 0.01), but no main effect for condition (p = 0.53).
Conclusion
Both HIIW and MICW in a hot environment caused an increase in biomarkers of kidney injury (IGFBP7, KIM-1, and NGAL), but HIIW may have a greater impact on biomarkers related to AKI.
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Abbreviations
- ηp 2 :
-
Partial eta-squared
- AKI:
-
Acute kidney injury
- eGFR:
-
Estimated glomerular filtration rate
- GFR:
-
Glomerular filtration rate
- Hct:
-
Hematocrit
- HR:
-
Heart rate
- IGFBP7:
-
Insulin-like growth factor binding protein 7
- KIM-1:
-
Kidney injury marker 1
- NGAL:
-
Neutrophil gelatinase-associated lipocalin
- Posm:
-
Plasma osmolality
- PV:
-
Plasma volume
- RH:
-
Relative humidity
- RPE:
-
Rating of perceived exertion
- Tc:
-
Core temperature
- TS:
-
Thermal stress
- UFR:
-
Urine flow rate
- Uosm:
-
Urine osmolality
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Funding
Partial funding for this study was provided by the Graduate and Professional Student Association and the Exercise Physiology Laboratory at the University of New Mexico.
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JH and FA conceived the experiment design. JH, ZM, ZF, JD, AW, and FA collected data. JH, ZM, FA, and JS analyzed the data. JH drafted the manuscript. All authors contributed to the final manuscript.
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This study was approved by the University of New Mexico Main Campus Institutional Review Board (protocol #1690849–3).
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Communicated by George Havenith.
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Houck, J., McKenna, Z., Fennel, Z. et al. The effect of interval and continuous work on markers of acute kidney injury in a hot environment. Eur J Appl Physiol 122, 2437–2450 (2022). https://doi.org/10.1007/s00421-022-05030-1
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DOI: https://doi.org/10.1007/s00421-022-05030-1