Abstract
Vascular and baroreceptor abnormalities in 44 young males, mean age 21 years, comprising of offspring with (FH+; n = 22) and without (FH−; n = 22) hypertensive parents, were investigated. Peak forearm blood flow (FBF), which was defined as the highest blood flow obtained following reactive hyperaemia, was assessed using strain gauge plethysmography following 5 min of ischemia. Cardiopulmonary baroreceptor sensitivity was assessed using lower body negative pressure for 5 min at −20 mmHg and was determined by calculating change of stroke volume and forearm vascular resistance (FVR) to lower body negative pressure. Carotid baroreceptor sensitivity was assessed using neck suction at −20, −40, −60, and −80 mmHg and was calculated by dividing RR interval by systolic blood pressure. Augmentation index, a measure of wave reflection, was assessed using applanation tonometry and was calculated as the ratio of augmented pressure and pulse pressure. Peak FBF of FH+ was 19% lower than the FH− (p = 0.02). Also FH+ had 17% higher peak FVR compared to FH− (p = 0.04). However, there were no significant differences between groups for cardiopulmonary, carotid baroreceptor sensitivity, and augmentation index. These results suggest that peripheral vascular dysfunction appears earlier than abnormal baroreceptor sensitivity in young males with a family history of hypertension.
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References
Barney JA, Ebert TJ, Groban L, Farrell PA, Hughes CV, Smith JJ (1988) Carotid baroreflex responsiveness in high-fit and sedentary young men. J Appl Physiol 65:2190–2194
Bevegård BS, Shepherd JT (1966) Circulatory effects of stimulating the carotid arterial stretch receptors in man at rest and during exercise. J Clin Invest 45:132–142
Bond V Jr, Franks BD, Tearney RJ, Wood B, Melendez MA, Johnson L et al (1994) Exercise blood pressure response and skeletal muscle vasodilator capacity in normotensives with positive and negative family history of hypertension. J Hypertens 12:285–290
Bristow JD, Honour AJ, Pickering GW, Sleight P, Smyth HS (1969) Diminished baroreflex sensitivity in high blood pressure. Circulation 39:48–54
Brum PC, Da Silva GJJ, Moreira ED, Ida F, Negrão CE, Krieger EM (2000) Exercise training increases baroreceptor gain sensitivity in normal and hypertensive rats. Hypertension 36:1018–1022
Durnin JVGA, Womersley J (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurement on the 481 men and women aged from 16 to 72 years. Br J Nutr 32:77–97
Eckberg DL, Cavanaugh MS, Mark AL, Abboud FM (1975) A simplified neck suction device for activation of carotid baroreceptors. J Lab Clin Med 85:167–173
Eckberg DL, Harkins SW, Fritsch JM, Musgrave GE, Gardner DF (1986) Baroreflex control of plasma norepinephrine and heart period in healthy subjects and diabetic patients. J Clin Invest 78:366–374
Eckberg DL, Rea RF, Andersson OK, Hedner T, Pernow J, Lundberg JM, Wallin BG (1988) Baroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans. Acta Physiol Scand 133:221–231
Folkow B (1992) Hypertension and endothelial function–aspects of atheroma protection. Blood Press Suppl 1:11–12
Franklin SS (2005) Arterial stiffness, hypertension: a two-way street? Hypertension 45:349–351
Hamer M, Boutcher YN, Boutcher SH (2003) The role of cardiopulmonary baroreceptors during the forearm vasodilatation response to mental stress in humans. Psychophysiology 40:249–253
Hisdal J, Toska K, Walløe L (2001) Beat to-beat cardiovascular responses to rapid, low-level LBNP in humans. Am J Physiol Regulatory Integrative Comp Physiol 281:R213–R221
Iwase N, Takata S, Ookuwa H, Ogawa J, Ikeda T, Hattori N (1984) Abnormal baroreflex control of heart rate in normotensive young subjects with a family history of essential hypertension. J Hypertens 2:409–411
Kouamé N, Nadeau A, Lacourciere Y, Cleroux J (1995) Effects of different training intensities on the cardiopulmonary baroreflex control of forearm vascular resistance in hypertensive subjects. Hypertension 25:391–398
Kubicek WG, Kottke FJ, Ramos MV, Patterson RP, Witsoe DA, Labree JW, Remole W, Layman TE, Schoening H, Garamela JT (1974) The Minnesota impedance cardiographic theory and applications. Biomed Eng 9:410–417
Lüscher TF, Yang ZH, Diederich D, Bühler FR (1989) Endothelium-derived vasoactive substances: potential role in hypertension, atherosclerosis, and vascular occlusion. J Cardiovasc Pharmacol 14:S63–S69
Mancia G, Leonetti G, Picotti GB, Ferrari A, Galva MD, Gregorini I, Parati G, Pomidossi G, Ravazzani C, Sala C, Zanchetti A (1979) Plasma catecholamines and blood pressure responses to the carotid baroreceptor reflex in essential hypertension. Clin Sci (Lond) 57:165s–167s
Mark AL (1984) Structural changes in resistance and capacitance vessels in borderline hypertension. Hypertension 6:III69–III73
Ookuwa H, Takata S, Ogawa J, Iwase N, Ikeda T (1987) Abnormal cardiopulmonary baroreflexes in normotensive young subjects with a family history of essential hypertension. J Clin Hypertens 3:596–604
Patterson GC, Whelan RF (1955) Reactive hyperemia in the human forearm. Clin Sci 14:197–211
Roberts DH, Tsao Y, Breckenridge AM (1986) The reproducibility of limb blood flow measurements in human volunteers at rest and after exercise by using mercury-in-Silastic strain gauge plethysmography under standardized condition. Clin Sci 70:635–638
Sherwood A, Allen MT, Fahrenberg J (1990) Methodological guidelines for impedance cardiography. Psychophysiology 27:1–23
Sopher SM, Smith ML, Eckberg DL, Fritsch JM, Dibner-Dunlap ME (1990) Autonomic pathophysiology in heart failure: carotid baroreceptor-cardiac reflexes. Am J Physiol 259:H689–H696
Takata S, Iwase N, Ookuwa H, Ogawa J, Ikeda T, Hattori N (1985) Baroreflex function and hypertension responsiveness in normotensive young subjects with a family history of hypertension. Jpn Circ J 49:990–996
Takeshita A, Mark AL (1980) Decreased vasodilatory capacity of forearm resistance vessels in borderline hypertension. Hypertension 2:610–615
Takeshita A, Tanaka S, Kuroiwa A, Nakamura M (1975) Reduced baroreceptor sensitivity in borderline hypertension. Circulation 51:738–742
Takeshita A, Imaizumi T, Ashihara T, Yamamoto K, Hoka S, Nakamura M (1982) Limited maximal vasodilator capacity of forearm resistance vessels in normotensive young men with a familial predisposition to hypertension. Cir Res 50:671–677
Takeshita A, Ashihara T, Yamamoto K, Imaizumi T, Hoka S, Ito N, Nakamura M (1984) Venous responses to salt loading in hypertensive subjects. Circulation 69:50–56
Yasmin, Falzone R, Brown MJ (2004) Determinants of arterial stiffness in offspring of families with essential hypertension. Am J Hypertens 17:292–298
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Boutcher, Y.N., Park, Y.J. & Boutcher, S.H. Vascular and baroreceptor abnormalities in young males with a family history of hypertension. Eur J Appl Physiol 107, 653–658 (2009). https://doi.org/10.1007/s00421-009-1170-y
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DOI: https://doi.org/10.1007/s00421-009-1170-y