Abstract
In order to test the hypothesis that salbutamol would change substrate oxidation during submaximal exercise, eight recreationally trained men twice performed 1 h at 60% VO2 peak after ingestion of placebo or 4 mg of salbutamol. Gas exchange was monitored and blood samples were collected during exercise for GH, ACTH, insulin, and blood glucose and lactate determination. With salbutamol versus placebo, there was no significant difference in total energy expenditure and substrate oxidation, but the substrate oxidation balance was significantly modified after 40 min of exercise. ACTH was significantly decreased with salbutamol during the last 10 min of exercise, whereas no difference was found between the two treatments in the other hormonal and metabolic parameters. The theory that the ergogenic effect of salbutamol results from a change in substrate oxidation has little support during relatively short term endurance exercise, but it is conceivable that longer exercise duration can generate positive findings.
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Acknowledgments
The authors wish also to express their gratitude to the subjects for their dedicated performance. In addition we likewise thank the CHR of Orléans, Nathalie Crépin, Sandra Ferary, Patrick Guenon, Nicole Chevrier and Dr M. Ferry for their assistance.
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Arlettaz, A., Le Panse, B., Portier, H. et al. Salbutamol intake and substrate oxidation during submaximal exercise. Eur J Appl Physiol 105, 207–213 (2009). https://doi.org/10.1007/s00421-008-0891-7
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DOI: https://doi.org/10.1007/s00421-008-0891-7