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Lowered microvascular vessel wall oxygen consumption augments tissue pO2 during PgE1-induced vasodilation

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Abstract

Continuous infusion of intravenous prostaglandin E1 (PgE1, 2.5 μg/kg/min) was used to determine how vasodilation affects oxygen consumption of the microvascular wall and tissue pO2 in the hamster window chamber model. While systemic measurements (mean arterial pressure and heart rate) and central blood gas measurements were not affected, PgE1 treatment caused arteriolar (64.6 ± 25.1 μm) and venular diameter (71.9 ± 29.5 μm) to rise to 1.15 ± 0.21 and 1.06 ± 0.19, respectively, relative to baseline. Arteriolar (3.2 × 10−2 ± 4.3 × 10−2 nl/s) and venular flow (7.8 × 10−3 ± 1.1 × 10−2/s) increased to 1.65 ± 0.93 and 1.32 ± 0.72 relative to baseline. Interstitial tissue pO2 was increased significantly from baseline (21 ± 8 to 28 ± 7 mmHg; P < 0.001). The arteriolar vessel wall gradient, a measure of oxygen consumption by the microvascular wall decreased from 20 ± 6 to 16 ± 3 mmHg (P < 0.001). The arteriolar vessel wall gradient, a measure of oxygen consumption by the vascular wall, decreased from 20 ± 6 to 16 ± 3 mmHg (P < 0.001). This reduction reflects a 20% decrease in oxygen consumption by the vessel wall and up to 50% when cylindrical geometry is considered. The venular vessel wall gradient decreased from 12 ± 4 to 9 ± 4 mmHg (P < 0.001). Thus PgE1-mediated vasodilation has a positive microvascular effect: enhancement of tissue perfusion by increasing flow and then augmentation of tissue oxygenation by reducing oxygen consumption by the microvascular wall.

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Acknowledgments

This research was conducted with the financial support of the Österreichische Nationalbank, Jubiläumsfondsprojekt 5526; “Fonds zur Förderung der Forschung an den Universitätskliniken Innsbruck,” MFF 49. This study was also supported by the USPHS Bioengineering Research Partnership grant R24-HL 64395, grants R01-HL 62318, R01-HL 62354 and R01-HL 76182.

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Authors and Affiliations

  1. Division of General and Surgical Intensive Care Medicine, Department of Anesthesia and Critical Care Medicine, The Leopold-Franzens-University of Innsbruck, Anichstr. 35, Innsbruck, 6020, Austria

    Barbara Friesenecker & J. Martini

  2. Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093-0412, USA

    A. G. Tsai & M. Intaglietta

  3. La Jolla Bioengineering Institute, La Jolla, CA, 92037, USA

    A. G. Tsai & M. Intaglietta

  4. Department of Intensive Care Medicine, University Hospital of Bern, Bern, Switzerland

    M. W. Dünser

  5. Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, 4910, Austria

    W. Hasibeder

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  1. Barbara Friesenecker
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  2. A. G. Tsai
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  3. M. W. Dünser
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  4. J. Martini
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  5. W. Hasibeder
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  6. M. Intaglietta
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Correspondence to Barbara Friesenecker.

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Friesenecker, B., Tsai, A.G., Dünser, M.W. et al. Lowered microvascular vessel wall oxygen consumption augments tissue pO2 during PgE1-induced vasodilation. Eur J Appl Physiol 99, 405–414 (2007). https://doi.org/10.1007/s00421-006-0360-0

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  • DOI: https://doi.org/10.1007/s00421-006-0360-0

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