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The course of non-infectious uveitis in pregnancy: a retrospective study of 79 pregnancies

  • Inflammatory Disorders
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Abstract

Purpose

The study aims to describe the course and management of non-infectious uveitis during pregnancy and postpartum period in European populations.

Methods

A retrospective observational study in two tertiary centers in France was performed. Pregnant patients during the follow-up of a non-infectious uveitis as well as those with new-onset uveitis were included. The medical records were analyzed with a systematic collection of the characteristics of the uveitis, the treatment and evolution of the uveitis, and the course of the pregnancy including obstetric complications.

Results

Seventy-nine pregnancies in 59 women were included: 48 patients (68 pregnancies) were followed for uveitis and 11 had a new-onset uveitis diagnosis. Most patients had idiopathic uveitis (32.2%) or sarcoid uveitis (27.1%). Among the patients followed for uveitis at the time of conception, there were 18 relapses (26.5%) requiring treatment escalation. Relapses occurred mainly in the two first trimester (n = 12) or during the postpartum period (n = 5) and were significantly associated with an active uveitis at the time of conception (OR = 9.2, 95% CI [1.57–48.4], p = 0.01). The characteristics of the new-onset uveitis were similar to those already existing before pregnancy. Obstetric complications occurred in 25 pregnancies (31.6%), mainly gestational hypertension and gestational diabetes.

Conclusion

The frequency of non-infectious uveitis relapses decreases as pregnancy progresses, in agreement with data from other non-European studies. However, multidisciplinary monitoring should be advised, especially to uncontrolled patients at the time of conception.

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Author information

Authors and Affiliations

  1. Service d’Immunologie Clinique et Médecine Interne, CNR RESO, Maladies Auto-Immunes Et Systémiques Rares, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    S. Giorgiutti, AS. Korganow & V. Poindron

  2. INSERM UMR - S1109, Université de Strasbourg, Strasbourg, France

    S. Giorgiutti, AS. Korganow & V. Poindron

  3. Service de Médecine Interne, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

    Y. Jamilloux, M. Gerfaud-Valentin, A. Bert & P. Sève

  4. LIFE, Lyon Immunopathology FEderation, Lyon, France

    Y. Jamilloux

  5. Service d’Ophtalmologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    L. Ballonzoli

  6. Service d’Ophtalmologie, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

    L. Kodjikian

  7. Université Lyon 1, Lyon, France

    L. Kodjikian

  8. UMR5510 MATEIS, CNRS, INSA Lyon, Université Lyon 1, 69100, Villeurbanne, France

    L. Kodjikian

  9. Hospices Civils de Lyon, Pôle IMER, Lyon, France

    P. Sève

  10. Université de Lyon, Université Claude Bernard-Lyon 1, HESPER EA 7425, Lyon, France

    P. Sève

Authors
  1. S. Giorgiutti
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  2. Y. Jamilloux
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  3. M. Gerfaud-Valentin
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  4. A. Bert
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  5. L. Ballonzoli
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  6. L. Kodjikian
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  7. AS. Korganow
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  8. V. Poindron
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  9. P. Sève
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Contributions

S. G. and P. S. were the principal investigators; they conceived and designed the study. S. G. collected the data. All authors interpreted the data and approved the manuscript. S. G. and P. S. drafted the manuscript. All authors reviewed the manuscript.

Corresponding author

Correspondence to S. Giorgiutti.

Ethics declarations

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Comité de Protection des Personnes Sud Est IV and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The present study received approval from the local ethics committee (CPP Sud Est IV) on February 2019 (N° 19–31) and was registered on www.clinicaltrials.gov (NCT 03863782).

Informed consent

According to French law, written consent for this study was not required due to its retrospective nature.

Conflict of interest

The authors declare no competing interests.

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Giorgiutti, S., Jamilloux, Y., Gerfaud-Valentin, M. et al. The course of non-infectious uveitis in pregnancy: a retrospective study of 79 pregnancies. Graefes Arch Clin Exp Ophthalmol 261, 1391–1398 (2023). https://doi.org/10.1007/s00417-022-05949-3

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