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Microvascular alterations in children with optic disk drusen evaluated by optical coherence tomography angiography

  • Pediatrics
  • Published:
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Abstract

Purpose

To asses changes in vessel density (VD) in children with optic disk drusen (ODD) using swept source optical coherence tomography angiography (OCTA).

Methods

Cross-sectional study of 27 eyes with ODD compared with age-matched controls. Peripapillary and macular VD were measured in the superficial retinal capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC). The correlation between VD changes with alterations in retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and visual field (VF) was analyzed.

Results

Mean participant age was 12.5 ± 3.3 years (range, 7–18 years); 63% was females. In the patients vs. controls, median central peripapillary VD was 52.9% vs. 50.6% (p = 0.63) for SCP; 48.1% vs. 53.8% (p = 0.017) for DCP; and 17.0% vs. 28.2% (p = 0.0037) for CC, respectively. VD in the superior and nasal CC layers was significantly lower in the patients (36.3% vs. 56.2%; p < 0.001) and (60.4% vs. 70.3%, p < 0.001), respectively. No significant differences were observed for VD in the macular region. The RNFL was thinner in eyes with superficial drusen versus controls (87 vs. 111 μm; p < 0.001). No significant differences between were observed in GCL thickness (p = 0.13). Nasal SCP and nasal RNFL VD were moderately correlated (r = 0.54, p < 0.01), while mean VF deviation was strongly correlated with median SCP VD in patients with superficial drusen (r = 0.9, p = 0.03).

Conclusion

Impaired VD was observed in the peripapillary nasal CC in patients with ODD; this impairment was associated with a decreased RNFL thickness. Nasal SCP VD and RNFL thickness were moderately correlated in patients with ODD.

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Acknowledgments

We want to thank Ana Royuela (Bioestatistic Unit, Puerta de Hierro Biomedical Research Institute) for her assistance in statistical analysis.

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Authors and Affiliations

  1. Department of Ophthalmology, University Hospital Puerta de Hierro Majadahonda, Joaquin Rodrigo 1, 28222, Madrid, Spain

    María Alarcón-Tomas, Bachar Kudsieh, Esther Casado Lopez-Franca, Yael Cohen & José M. Ruiz-Moreno

  2. Centro Internacional de Oftalmología Avanzada, Madrid, Spain

    Bachar Kudsieh

  3. Castilla La Mancha University, Albacete, Spain

    José M. Ruiz-Moreno

Authors
  1. María Alarcón-Tomas
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  2. Bachar Kudsieh
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  3. Esther Casado Lopez-Franca
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  4. Yael Cohen
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  5. José M. Ruiz-Moreno
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Corresponding author

Correspondence to María Alarcón-Tomas.

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The authors declare that they have no conflict of interest.

Ethical approval

Approval was obtained from the ethics committee of University Hospital Puerta de Hierro. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Informed consent was obtained from all individual participants included in the study.

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Alarcón-Tomas, M., Kudsieh, B., Lopez-Franca, E.C. et al. Microvascular alterations in children with optic disk drusen evaluated by optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol 259, 769–776 (2021). https://doi.org/10.1007/s00417-020-04970-8

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  • DOI: https://doi.org/10.1007/s00417-020-04970-8

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