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Relationship between the 24-h variability of blood pressure, ocular perfusion pressure, intraocular pressure, and visual field defect in thyroid associated orbitopathy

  • Oculoplastics and Orbit
  • Published:
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Abstract

Purpose

To evaluate the relationship between the 24-h variability of blood pressure (BP), ocular perfusion pressure (OPP), intraocular pressure (IOP), and visual field (VF) defect in thyroid-associated orbitopathy (TAO).

Methods

Thirty patients (60 eyes) with TAO were clinically examined in the Eye Hospital of Wenzhou Medical University. Patients were divided into two groups: one with VF defect (A) and the other without (B). Clinical parameters measured include 24-h IOP, 24-h blood pressure, orbital computed tomography (CT) scan, optical coherence tomography (OCT), and VFs. The pulse pressure (PP), mean arterial pressure (MAP), mean ocular perfusion pressure (MOPP), and 24-h fluctuations were calculated by formula.

Results

The MOPP and MAP fluctuation were greater in group A than B (p < 0.05) and had significant negative correlation to mean deviation (MD) of VF (R = − 0.434 P = 0.001*). There was no statistical difference in the muscle index, medial rectus muscle thickness, and blood pressure between two groups. Although there were no significant differences in the mean IOP and IOP fluctuation between two groups, the incidence of IOP abnormalities has higher trend in group A. Patients with 24-h IOP fluctuation ≥8 mmHg and the mean IOP > 21 mmHg in the group A were more than group B.

Conclusions

Dysthyroid optic neuropathy (DON) might have multiple pathogenic mechanisms. In this study, 24-h MOPP fluctuation and medial rectus maximal diameter were all the risk factors for DON. Higher mean IOP and 24-h IOP fluctuation might be risk factors for DON.

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Funding

This study was funded by the Zhejiang Provincial Natural Science Foundation of China (grant number LY19H120003), the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (grant number 2020KY192), and the Eye Hospital of Wenzhou Medical University (grant number YNCX201314).

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Authors and Affiliations

  1. Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, People’s Republic of China

    Yunhai Tu, Weijie Liu, Mingna Xu, Qi Chen & Wencan Wu

  2. Lishui Municipal Central Hospital, Lishui, China

    Bangxun Mao & Jiagen Li

Authors
  1. Yunhai Tu
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  2. Bangxun Mao
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  3. Jiagen Li
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  4. Weijie Liu
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  6. Qi Chen
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  7. Wencan Wu
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Contributions

YHT, BXM, and WCW conceived and designed the study. JGL, and QC performed the experiments. YHT wrote the paper. YHT, BXM, JGL, WJL, MNX and QC reviewed and edited the manuscript. All authors read and approved the manuscript.

Corresponding author

Correspondence to Wencan Wu.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Ethical approval was waived by the local Ethics Committee of Wenzhou Medical University in view of the retrospective nature of the study, and all the procedures being performed were part of the routine care. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board and with the Helsinki declaration and its later amendments or comparable ethical standards.

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For this type of study, formal consent is not required.

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The participants provided informed consent. Patient information was anonymized and de-identified prior to analysis.

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Tu, Y., Mao, B., Li, J. et al. Relationship between the 24-h variability of blood pressure, ocular perfusion pressure, intraocular pressure, and visual field defect in thyroid associated orbitopathy. Graefes Arch Clin Exp Ophthalmol 258, 2007–2012 (2020). https://doi.org/10.1007/s00417-020-04733-5

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  • DOI: https://doi.org/10.1007/s00417-020-04733-5

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