Abstract
Purpose
To study focal choroidal excavations in patients with Best vitelliform dystrophy using optical coherence tomography and their topographical relation with fibrotic pillars.
Methods
This is a retrospective cross-sectional study of consecutive patients diagnosed with Best vitelliform dystrophy at a tertiary eye care center. Records of patients with Best vitelliform dystrophy were reviewed for best-corrected visual acuity, color fundus photographs, shortwave autofluorescence, optical coherence tomography, and electrooculogram with special emphasis on the presence of focal choroidal excavation (FCE) and fibrotic pillar. Main outcome measure was to study the fibrotic pillar in relation to the FCE.
Results
Thirty-eight eyes of 19 patients with mean age of 34.6 years were enrolled in the study. FCE was seen in eight eyes of six patients. Two patients had bilateral FCE and all the FCEs were located in the area of vitelliform lesion. Six out of eight eyes with FCE were in vitelliruptive stage of disease; one was in pseudohypopyon stage and one in atrophic stage. A fibrotic pillar was seen lying directly above the FCE in seven eyes. In one eye, hyper-reflective material not amounting to fibrotic pillar was seen lying above the FCE.
Conclusion
A focal choroidal excavation in the setting of Best vitelliform dystrophy is seen predominantly in the vitelliruptive stage of the disease. Fibrotic pillars appear to play a role in the formation of these FCEs.
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All procedures performed in this report were in accordance with the institutional guidelines and with the 1964 Helsinki declaration and its later amendments. For this type of study, formal consent is not required.
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Informed consent was obtained from all the patients and data is non-identifiable.
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Kumar, V., Chatra, K. Fibrotic pillar leads to focal choroidal excavation in Best vitelliform dystrophy. Graefes Arch Clin Exp Ophthalmol 256, 2083–2087 (2018). https://doi.org/10.1007/s00417-018-4120-8
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DOI: https://doi.org/10.1007/s00417-018-4120-8