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Lamellar macular holes in the eyes with pathological myopia

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To study the natural history and morphologic characteristics of lamellar macular holes (LMHs) in the eyes with pathological myopia.

Methods

Retrospective observational case series of 44 eyes of 44 patients examined at a single institutional vitreoretinal practice. The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence tomography (SD-OCT) and an area of increased autofluorescence on blue fundus autofluorescence (B-FAF) to be included. Presence of retinoschisis and posterior staphyloma, posterior vitreous status, changes of logarithm of minimum angle of resolution best-corrected visual acuity (BCVA), and changes of morphologic characteristics were evaluated.

Results

The mean follow-up period was 50.1 ± 28.9 months; 75% of the enrolled patients were female. At baseline, a standard epiretinal membrane (ERM) was detected in 93.2%, lamellar hole-associated epiretinal proliferation (LHEP) in 75%, and concomitant ERM and LHEP in 68.2% of the eyes, respectively. Visual acuity did not correlate with LMH diameters but correlated with central foveal thickness (p < 0.001). During the follow-up, the morphologic and functional parameters studied were relatively stable/improved in 60% of the eyes independently from the associated epiretinal material. Four eyes evolved to full-thickness (FT) MHs whereas spontaneous improvement was observed in five cases.

Conclusions

LMHs in highly myopic eyes are more prevalent in females, are frequently associated with ERM and LHEP, and show substantial stability of BCVA and the anatomic parameters evaluated with B-FAF and SD-OCT over years-long follow-up.

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Authors and Affiliations

  1. Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, Via Francesco De Sanctis 1, 86100, Campobasso, Italy

    Roberto dell’Omo, Serena De Turris & Ciro Costagliola

  2. Casa di Cura “Villa Maria”, Campobasso, Italy

    Roberto dell’Omo, Ermanno dell’Omo & Ciro Costagliola

  3. Department of Translational Surgery and Medicine, University of Florence, Florence, Italy

    Gianni Virgili

  4. Eye Clinic, Department of Biomedical and Clinical Science “Luigi Sacco”, Sacco Hospital, University of Milan, Milan, Italy

    Ferdinando Bottoni

  5. Department of Ophthalmology, Sant’Anna Institute, Brescia, Italy

    Barbara Parolini & Attilo Di Salvatore

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  1. Roberto dell’Omo
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  2. Gianni Virgili
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  4. Barbara Parolini
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Correspondence to Roberto dell’Omo.

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All procedures were in accordance with the ethical standards of the institutional research committee (Institutional Review Board of the University of Molise) and with the 1964 Helsinki declaration and its later amendments.

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dell’Omo, R., Virgili, G., Bottoni, F. et al. Lamellar macular holes in the eyes with pathological myopia. Graefes Arch Clin Exp Ophthalmol 256, 1281–1290 (2018). https://doi.org/10.1007/s00417-018-3995-8

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  • DOI: https://doi.org/10.1007/s00417-018-3995-8

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