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Parafoveal and optic disc vessel density in patients with obstructive sleep apnea syndrome: an optical coherence tomography angiography study

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Aims

To compare optic disc perfusion, radial peripapillary capillaries (RPC) and macular vascular density, between normal subjects and subjects with obstructive sleep apnea syndrome (OSAS) using spectral-domain OCT angiography (OCTA).

Methods

Sixteen eyes of patients with mild OSAS, 17 eyes with moderate OSAS, 20 eyes with severe OSAS on polygraphy and 28 controls were evaluated with OCTA RT XR Avanti (AngioVue software, Optovue Inc., Fremont, CA). Optic nerve head (ONH), RPC and macular vessel density were measured. Clinical data, visual field parameters, and Spectral Domain OCT evaluation (retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) thickness) were recorded for all patients.

Results

ONH vascular flow (p = 0,396), RPC vascular density (automatized data “whole” p = 0,913, “peripapillary” p = 0,539, and segmented analysis with a topographic grid) and macular vascular density (foveal p = 0,484, parafoveal p = 0,491) were not significantly different between the four groups. FDT-Matrix™ and Humphrey 24/2 mean deviation were significantly lower in eyes with severe OSAS and were correlated to the apnea-hypopnea index. Retinal nerve fiber layer (RNFL) thickness, Cup/Disc ratio, rim area, and ganglion cell complex (GCC) were not significantly modified.

Conclusions

OCTA did not detect reduced ONH, RPC, neither macular blood vessel density in eyes with OSAS. The precise mechanisms that link OSAS with optic nerve pathologies remain unclear: our study was not able to demonstrate a vascular impact by OCTA examination.

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Funding

No funding was received for this research.

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Authors and Affiliations

  1. Department of Ophthalmology, Centre Hospitalier National d’Ophtalmologie des CHNO Quinze-Vingts, 28 rue de Charenton, 75012, Paris, France

    Laura Moyal, Esther Blumen-Ohana, Cybele Blatrix & Jean-Philippe Nordmann

  2. Department of Oto-Rhino-Laryngology, Hôpital Foch, Suresnes, France

    Marc Blumen & Frederic Chabolle

  3. Centre Médical Veille Sommeil (CMVS), Paris, France

    Marc Blumen

Authors
  1. Laura Moyal
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  2. Esther Blumen-Ohana
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  3. Marc Blumen
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  4. Cybele Blatrix
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  5. Frederic Chabolle
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  6. Jean-Philippe Nordmann
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Corresponding author

Correspondence to Laura Moyal.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Ethics Committee of the French Society of Ophthalmology) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Moyal, L., Blumen-Ohana, E., Blumen, M. et al. Parafoveal and optic disc vessel density in patients with obstructive sleep apnea syndrome: an optical coherence tomography angiography study. Graefes Arch Clin Exp Ophthalmol 256, 1235–1243 (2018). https://doi.org/10.1007/s00417-018-3943-7

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  • DOI: https://doi.org/10.1007/s00417-018-3943-7

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