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The incidental findings of age-related macular degeneration during diabetic retinopathy screening

  • Retinal Disorders
  • Published:
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Abstract

Background

The purpose of this study was to determine the reliability of detecting age-related macular degeneration (AMD) during screening for diabetic retinopathy (DR).

Methods

This prospective study included 2,003 subjects with diabetes mellitus who underwent photographic screening for DR. The reliability of detecting AMD lesions was tested by interobserver and intraobserver agreement, and the sensitivity and specificity of diagnosing AMD at different grades of severity were tested using the consensus grading of a group as the reference standard.

Results

DR affected 24.7 % of the subjects. The age-standardized prevalence of early AMD was 17.9 %, and late AMD was 0.1 %. The interobserver and intraobserver agreement for grading AMD was substantial (k = 0.72 and 0.71 respectively, p < 0.001). It was equally good in those with different severities of DR. There was also no difference in sensitivity and specificity of detecting AMD in those with different levels of DR (sensitivity 62–68 % and specificity 97–98 %).

Conclusion

Intermediate- and high-risk AMD that warrant treatment with zinc and anti-oxidant supplements could be reliably detected during screening for diabetic retinopathy.

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Conflict of interest

No conflicting relationship exists for any author.

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Authors and Affiliations

  1. Department of Ophthalmology, The University of Hong Kong, Room 301, Block B, Cyberport 4, 100 Cyberport Road, Cyberport, Hong Kong

    Rita Gangwani, Wico W. Lai, Catherine W. S. Chan & David Wong

  2. School of Public Health, The University of Hong Kong, Hong Kong, SAR, China

    Sarah M. McGhee & Anthony J. Hedley

  3. School of Optometry, The Hong Kong Polytechnic University, Hong Kong, SAR, China

    Rita Sum

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  1. Rita Gangwani
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  2. Wico W. Lai
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  3. Rita Sum
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  4. Sarah M. McGhee
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  7. David Wong
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Correspondence to Rita Gangwani.

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Gangwani, R., Lai, W.W., Sum, R. et al. The incidental findings of age-related macular degeneration during diabetic retinopathy screening. Graefes Arch Clin Exp Ophthalmol 252, 723–729 (2014). https://doi.org/10.1007/s00417-013-2530-1

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  • DOI: https://doi.org/10.1007/s00417-013-2530-1

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