Skip to main content

Advertisement

SpringerLink
Log in

Cerebellar degeneration and polyglandular autoimmune syndrome with anti-glutamic acid decarboxylase antibodies

  • Letter To The Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Abele M, Weller M, Mescheriakov S, et al. (1999) Cerebellar ataxia with glutamic acid decarboxylase autoantibodies. Neurology 52:857–859

    Article  CAS  PubMed  Google Scholar 

  2. Baekkeskov S, Aanstoot AJ, Christgau S, et al. (1990) Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347:151–156

    Article  CAS  PubMed  Google Scholar 

  3. Daw K, Ujihara N, Atkinson M, et al. (1996) Glutamic acid decarboxylase autoantibodies in stiffman syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition. J Immunol 156:818–825

    CAS  PubMed  Google Scholar 

  4. Dinkel K, Meinck MH, Jury KM, et al. (1998) Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiffman syndrome. Ann Neurol 43: 194–201

    Article  Google Scholar 

  5. Giometto B, Miotto D, Faresin F, et al. (1996) Anti-gabaergic neuron antibodies in a patient with stiff-man-syndrome and ataxia. J Neurol Sci 143: 57–59

    Article  CAS  PubMed  Google Scholar 

  6. Grimaldi LME, Quatrini A, Martino G, et al. (1990) Cerebellar autoantibodies in patients with isolated or associated stiff-man syndrome and cerebellar atrophies. Neurology 40(suppl): S117–S118 (abstract)

    Google Scholar 

  7. Honnorat J, Trouillas P, Thivolet C, et al. (1995) Autoantibodies to glutamate decarboxylase in a patient with cerebellar cortical atrophy, peripheral neuropathy, and slow eye movements. Arch Neurol 52:462–468

    Article  CAS  PubMed  Google Scholar 

  8. Honorat J, Saiz A, Giometto B, et al. (2001) Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies. Arch Neurol 58:225–230

    Article  Google Scholar 

  9. Ishida K, Mitoma H, Song SY, et al. (1999) Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase. Ann Neurol 46:263–267

    Article  CAS  PubMed  Google Scholar 

  10. Kim J, Namchuk M, Bugawan T, et al. (1994) Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiffman syndrome from insulin-dependent diabetes mellitus. J Exp Med 180:595–606

    Article  CAS  PubMed  Google Scholar 

  11. Levy LM, Dalakas MC, Floeter MK (1999) The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid. Ann Intern Med 131:522–530

    Article  CAS  PubMed  Google Scholar 

  12. Lohmann T, Hawa M, Leslie RDG, et al. (2000) Immune reactivity to glutamic acid decarboxylase 65 in stiff-man syndrome and type 1 diabetes mellitus. Lancet 356:31–35

    Article  CAS  PubMed  Google Scholar 

  13. Mitoma H, Song SY, Ishida K, et al. (2000) Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase. J Neurol Sci 175:40–44

    Article  CAS  PubMed  Google Scholar 

  14. Peltola J, Kulmala P, Isojärvi, et al. (2000) Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy. Neurology 55: 46–50

    Article  CAS  PubMed  Google Scholar 

  15. Saiz A, Arpa J, Sagasta A, et al. (1997) Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity. Neurology 49:1026–1030

    Article  CAS  PubMed  Google Scholar 

  16. Solimena M, Piccolo G, Martino G, et al. (1988) Autoantibodies directed against gabaergic nerve terminals in a patient with idiopathic late-onset cerebellar ataxia and type 1B diabetes mellitus. Clin Neuropathol 7(suppl):211 (abstract)

    Google Scholar 

  17. Takenoshita H, Shizuka-Ikeda M, Mitoma H, et al. (2001) Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J Neurol Neurosurg Psychiatry 70:386–389

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Tuomilehto J, Zimmet P, Mackay IR, et al. (1994) Antibodies to glutamic acid decarboxylase as predictors of insulindependent diabetes mellitus before clinical onset of disease. Lancet 343: 1383–1385

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. David Mahoney Institute of Neurological Sciences 467, Stemmler Hall, University of Pennsylvania, 3400, Spruce Street, Philadelphia, PA, 19104, USA

    S. Rüegg MD

  2. Department of Neurology, University Hospital, Petersgraben 4, 4031, Basel, Switzerland

    M. Bühlmann MD, A. Dupont MD, P. A. Lyrer MD & A. J. Steck MD

  3. Division of Endocrinology of the Department of Internal Medicine, University Hospital, Basel, Switzerland

    M. Stahl MD

  4. Laboratory of Biochemistry-Immunpathology, Hospital Center of Luxembourg, Luxembourg

    R. L. Humbel PhD

Authors
  1. S. Rüegg MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Bühlmann MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Dupont MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. A. Lyrer MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. J. Steck MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Stahl MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. L. Humbel PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Rüegg MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rüegg, S., Bühlmann, M., Dupont, A. et al. Cerebellar degeneration and polyglandular autoimmune syndrome with anti-glutamic acid decarboxylase antibodies. J Neurol 249, 348–350 (2002). https://doi.org/10.1007/s004150200019

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004150200019

Keywords

Search

Navigation