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Wake-up stroke and sleep-disordered breathing: a meta-analysis of current studies

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Abstract

Sleep-disordered breathing (SDB) is a frequent comorbidity in patients with wake-up stroke (WUS). It affects the occurrence of this disease through its interference of breathing changes and sleep quality. We aim to assess the performances of sleep-disordered breathing in WUS. A systematical search for the studies that investigated sleep-disordered breathing in WUS was done in PubMed, Web of Science, and Cochrane Library. Data were extracted by two independent investigators, and then analyzed using the Revman 5.0 software. A total of five studies with 591 patients were included in the meta-analysis. The pooling data of sleep parameters showed that patients with WUS had a higher AHI and ODI than those with non-WUS (NWUS) [AHI: SMD: 0.58 (0.05, 1.10), P = 0.03; ODI: SMD: 0.63 (0.06, 1.21), P = 0.03). In addition, an increased incidence of severe SAS is found in WUS (OR: 3.18; 95% CI 1.27, 7.93; P = 0.01). However, no differences were found in AI, ESS, and the number of sleep apnea syndrome (SAS) between the two groups (P > 0.05). Therefore, WUS patients intended to have a severe SDB status, affecting the respiratory effects. Early prevention and attention should be paid on potential stroke sufferers with SAS, especially those with severe SAS.

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Acknowledgements

This study was supported by grants from the National Natural Science Foundation of China (Grant No. 81401190) and Natural Science Foundation of Hunan Province (Grant No. 2017JJ3273).

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  1. Zijian Xiao and Ming Xie contributed equally to this study.

Authors and Affiliations

  1. The First Affiliated Hospital of University of South China, University of South China, No. 69, Chuanshan Road, Hengyang, 421001, Hunan, China

    Zijian Xiao, Ming Xie, Yong You, Heng Wu, Guijuan Zhou & Mingyong Li

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  1. Zijian Xiao
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  2. Ming Xie
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  3. Yong You
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  4. Heng Wu
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Correspondence to Guijuan Zhou or Mingyong Li.

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The manuscript does not contain clinical studies or patient data.

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415_2018_8810_MOESM1_ESM.jpg

Supplementary Figure 1. Meta-analysis of ESS. WUS wake-up stroke, NWUS non-WUS, ESS Epworth Sleepiness Scale (JPEG 223 kb)

Supplementary Figure 2. Meta-analysis of SAS. WUS wake-up stroke, NWUS non-WUS, SAS sleep apnea syndrome (JPEG 184 kb)

Supplementary material 3 (DOCX 13 kb)

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Xiao, Z., Xie, M., You, Y. et al. Wake-up stroke and sleep-disordered breathing: a meta-analysis of current studies. J Neurol 265, 1288–1294 (2018). https://doi.org/10.1007/s00415-018-8810-2

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  • DOI: https://doi.org/10.1007/s00415-018-8810-2

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