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Clinical characteristics of myelin oligodendrocyte glycoprotein seropositive optic neuritis: a cohort study in Shanghai, China

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Abstract

Qualitative and quantitative visual outcomes of Asian optic neuritis (ON) patients with seropositive myelin oligodendrocyte glycoprotein (MOG) antibodies remain unknown. We retrospectively evaluated a cohort of new-onset ON patients in Shanghai, China between January 2015 and December 2016. Serum MOG and aquaporin-4 (AQP4) antibodies were detected using cell-based assays, and patients were followed-up for at least 6 months. The clinical characteristics and optical coherence tomography (OCT) results were evaluated in the MOG-seropositive optic neuritis (MOG-ON), AQP4-seropositive (AQP4-ON), and double seronegative (Seronegative-ON) patients. Best-corrected visual acuity (BCVA) and peripapillary retinal nerve fiber layer (RNFL) thickness after 6 months of follow-up were compared. Among MOG-ON (n = 49, 64 eyes), AQP4-ON (n = 76, 102 eyes), and Seronegative-ON patients (n = 100, 116 eyes), the percentages of BCVAs better than 0.8 (20/25) at the 6-month visit were 67.19, 19.60, and 72.41%, respectively, which showed no statistical difference between MOG-ON and Seronegative-ON patients (p = 0.198), but were better than the AQP4-ON patients (P = 0.001). The average peripapillary RNFLs measured 6 months after the attack were 58.03 ± 8.73, 64.34 ± 12.88, and 78.12 ± 13.34 μm for the MOG-ON, AQP4-ON, and Seronegative-ON patients, respectively. There was no statistical difference between MOG-ON and AQP4-ON patients (P = 0.089), but both were thinner than Seronegative-ON patients (P = 0.001). The visual acuity in MOG-ON patients was as good as Seronegative-ON patients, whereas the RNFL of the optic nerve head showed a significant thinning as in the AQP4-ON patients.

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Acknowledgements

We thank Larry Takemoto, Ph.D., for editing the English text of a draft of this manuscript.

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Authors and Affiliations

  1. Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China

    Guixian Zhao & Zhenxin Li

  2. Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China

    Qian Chen, Yongheng Huang, Xinghuai Sun, Min Wang & Guohong Tian

  3. Department of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China

    Ping Lu & S. Yan

  4. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China

    Xinghuai Sun, Min Wang & Guohong Tian

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  1. Guixian Zhao
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  2. Qian Chen
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  8. Min Wang
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Contributions

Conception and design by GZ, GT, MW. Analysis and interpretation by QC, YH, GT. Data collection by GZ, YH, P L, GT. Obtained funding by GZ, GT. Overall responsibility: ZL, XS, YS, GT.

Corresponding authors

Correspondence to Min Wang or Guohong Tian.

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Conflicts of interest

The authors have no proprietary or commercial interest in any materials discussed in this article.

Ethical statement

This study was approved by the Eye Ear Nose and Throat hospital ethics committee. All subjects participated in this study were under written information procedure and written consents were obtained.

Human and animal rights

The study is a retrospective clinical data analysis and therefor does not involve human or animal research.

Funding

This work is supported by the National Nature Science funding in China, 81301027 and Talent Doctor Project in Fudan University, Shanghai.

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Zhao, G., Chen, Q., Huang, Y. et al. Clinical characteristics of myelin oligodendrocyte glycoprotein seropositive optic neuritis: a cohort study in Shanghai, China. J Neurol 265, 33–40 (2018). https://doi.org/10.1007/s00415-017-8651-4

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  • DOI: https://doi.org/10.1007/s00415-017-8651-4

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