Skip to main content
Log in

No evidence for an association between genetic variation at the MMP2 and MMP9 loci and aneurysmal subarachnoid haemorrhage

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Ferro JM, Canhao P, Peralta R (2008) Update on subarachnoid haemorrhage. J Neurol 255:465–479

    Article  PubMed  Google Scholar 

  2. Nahed BV, Bydon M, Ozturk AK, Bilguvar K, Bayrakli F, Gunel M (2007) Genetics of intracranial aneurysms. Neurosurgery 60:213–225

    Article  PubMed  Google Scholar 

  3. Kim SC, Singh M, Huang J, Prestigiacomo CJ, Winfree CJ, Solomon RA, Connolly ES Jr (1997) Matrix metalloproteinase-9 in cerebral aneurysms. Neurosurgery 41:642–666

    PubMed  CAS  Google Scholar 

  4. Jin D, Sheng J, Yang X, Gao B (2007) Matrix metalloproteinases and tissue inhibitors of metalloproteinases expression in human cerebral ruptured and unruptured aneurysm. Surg Neurol 68(Suppl 2):S11–S17

    Google Scholar 

  5. Nylén K, Csajbok LZ, Ost M, Rashid A, Blennow K, Nellgård B, Rosengren L (2007) Serum glial fibrillary acidic protein is related to focal brain injury and outcome after aneurysmal subarachnoid hemorrhage. Stroke 38:1489–1494

    Article  PubMed  Google Scholar 

  6. Ladenvall C, Csajbok L, Nylén K, Jood K, Nellgård B, Jern C (2009) Association between factor XIII single nucleotide polymorphisms and aneurysmal subarachnoid hemorrhage. J Neurosurg 110:475–481

    Article  PubMed  CAS  Google Scholar 

  7. Krex D, Kotteck K, König IR, Ziegler A, Schackert HK, Schackert G (2004) Matrix metalloproteinase-9 coding sequence single-nucleotide polymorphisms in Caucasians with intracranial aneurysms. Neurosurgery 55:207–212

    Article  PubMed  Google Scholar 

  8. Yoon S, Tromp G, Vongpunsawad S, Ronkainen A, Juvonen T, Kuivaniemi H (1999) Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms. Biochem Biophys Res Commun 265:563–568

    Article  PubMed  CAS  Google Scholar 

  9. Zhang B, Dhillon S, Geary I, Howell WM, Iannotti F, Day IN, Ye S (2001) Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage. Stroke 32:2198–2202

    Article  PubMed  CAS  Google Scholar 

  10. Kaplan RC, Smith NL, Zucker S, Heckbert SR, Rice K, Psaty BM (2008) Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke. Atherosclerosis 201:130–137

    Article  PubMed  CAS  Google Scholar 

  11. Pannu H, Kim DH, Guo D, King TM, Van Ginhoven G, Chin T, Chang K, Qi Y, Shete S, Milewicz DM (2006) The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. J Neurosurg 105:418–423

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This study was supported by the Swedish Research Council (K2011-65X-14605-09-6), the Swedish state (ALFGBG-148861), the Swedish Heart and Lung Foundation (20100256), as well as the Rune and Ulla Amlöv, Edit Jacobson, John and Brit Wennerström, Lars Hierta O.E. and Edla Johansson, Tore Nilsson, and Emelle Foundations.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sandra Olsson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Olsson, S., Csajbok, L.Z., Jood, K. et al. No evidence for an association between genetic variation at the MMP2 and MMP9 loci and aneurysmal subarachnoid haemorrhage. J Neurol 259, 193–195 (2012). https://doi.org/10.1007/s00415-011-6157-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-011-6157-z

Keywords

Navigation