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Migraine-associated risks and comorbidity

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Abstract

This review reports important co-morbid conditions of migraine and resulting consequences for the choice of acute and preventive treatments of migraine. Comorbidity in this context means the occurrence of two diseases in an individual beyond chance. The basis of comorbidity can be genetic and/or based on common environmental factors. In some cases, the temporal relationship is unclear and one disease can cause another disease. In order to prove a real comorbidity, large-scale and wellperformed epidemiological studies are required.

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References

  1. Aamodt AH, Stovner LJ, Langhammer A, Hagen K, Zwart JA (2007) Is Headache Related to Asthma, Hay Fever, and Chronic Bronchitis? The Head-HUNT Study. Headache 47:204–212

    Article  PubMed  Google Scholar 

  2. Adeney KL, Williams MA, Miller RS, Frederick IO, Sorensen TK, Luthy DA (2005) Risk of preeclampsia in relation to maternal history of migraine headaches. J Matern Fetal Neonatal Med 18:167–172

    Article  PubMed  Google Scholar 

  3. Ahmed B, Bairey Merz CN, McClure C, Johnson BD, Reis SE, Bittner V, Pepine CJ, Sharaf BL, Sopko G, Kelsey SF, Shaw L; WISE study group (2006) Migraines, angiographic coronary artery disease and cardiovascular outcomes in women. Am J Med: 119:670–675

    Article  PubMed  Google Scholar 

  4. Albera R, Ciuffolotti R, Di Cicco M, De Benedittis G, Grazioli I, Melzi G, Mira E, Pallestrini E, Passali D, Serra A, Vicini C (2003) Double-blind, randomized, multicenter study comparing the effect of betahistine and flunarizine on the dizziness handicap in patients with recurrent vestibular vertigo. Acta Otolaryngol 123:588–593

    Article  PubMed  CAS  Google Scholar 

  5. Al-Twaijri WA, Shevell MI (2002) Pediatric migraine equivalents: occurrence and clinical features in practice. Pediatr Neurol 26:365–368

    Article  PubMed  Google Scholar 

  6. Anzola GP, Frisoni GB, Morandi E, Casilli F, Onorato E (2006) Shunt-associated migraine responds favorably to atrial septal repair: a case-control study. Stroke 37: 430–434

    Article  PubMed  Google Scholar 

  7. Anzola GP, Magoni M, Guindani M, Rozzini L, Dalla Volta G (1999) Potential source of cerebral embolism in migraine with aura: a transcranial Doppler study. Neurology 52:1622–1625

    PubMed  CAS  Google Scholar 

  8. Artto V, Wessman M, Nissila M, Sako E, Liukkonen J, Teirmaa H, Harno H, Havanka H, Ilmavirta M, Palotie A, Farkkila M, Kallela M (2006) Comorbidity in Finnish migraine families. J Headache Pain 7:324–330

    Article  PubMed  CAS  Google Scholar 

  9. Axon A, Long D, Jones S (1991) Abdominal migraine: does it exist? J Clin Gastroenterol 13:615–616

    Article  PubMed  CAS  Google Scholar 

  10. Azarbal B, Tobis J, Suh W, Chan V, Dao C, Gaster R (2005) Association of interatrial shunts and migraine headaches: impact of transcatheter closure. J Am Coll Cardiol 15:489–492

    Article  Google Scholar 

  11. Bendtsen L, Jensen R (2004) Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. Neurology 62:1706–1711

    PubMed  CAS  Google Scholar 

  12. Bendtsen L, Jensen R, Olesen J (1996) A non-selective (amitriptyline), but no a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. J Neurol Neurosurg Psychiatry 61:285–290

    PubMed  CAS  Google Scholar 

  13. Blau JN, MacGregor EA (1995) Is abdominal pain a feature of adult migraine? Headache 35:207–209

    Article  PubMed  CAS  Google Scholar 

  14. Boccia G, Del Giudice E, Crisanti AF, Strisciuglio C, Romano A, Staiano A (2006) Functional gastrointestinal disorders in migrainous children: efficacy of flunarizine. Cephalalgia 26:1214–1219

    Article  PubMed  CAS  Google Scholar 

  15. Bousser MG, Welch KM (2005) Relation between migraine and stroke. Lancet Neurol 4:533–542

    Article  PubMed  Google Scholar 

  16. Brandes JL, Visser WH, Farmer MV, Schuhl AL, Malbecq W, Vrijens F, Lines CR, Reines SA; Protocol 125 study group (2004) Montelukast for migraine prophylaxis: a randomized, double-blind, placebo-controlled study. Headache 44:581–586

    Article  PubMed  Google Scholar 

  17. Breslau N, Rasmussen BK (2001) The impact of migraine: Epidemiology, risk factors, and co-morbidities. Neurology 56:S4–S12

    PubMed  CAS  Google Scholar 

  18. Buring JE, Hebert P, Romero J, Kittross A, Cook N, Manson J, Peto R, Hennekens C (1995) Migraine and subsequent risk of stroke in the Physicians’ Health Study. Arch Neurol 52:129–134

    PubMed  CAS  Google Scholar 

  19. Buring JE, Peto R, Hennekens CH (1990) Low-dose aspirin for migraine prophylaxis. JAMA 264:1711–1713

    Article  PubMed  CAS  Google Scholar 

  20. Bussone G, Diener H, Pfeil J, Schwalen S (2005) Topiramate 100 mg/day in migraine prevention: a pooled analysis of double-blind randomised controlled trials. Int J Clin Pract 59:961–968

    Article  PubMed  CAS  Google Scholar 

  21. Carod-Artal FJ, da Silveira Ribeiro L, Braga H, Kummer W, Mesquita HM, Vargas AP (2006) Prevalence of patent foramen ovale in migraine patients with and without aura compared with stroke patients. A transcranial Doppler study. Cephalalgia 26:934–939

    Article  PubMed  CAS  Google Scholar 

  22. Carolei A, Marini C, De Matteis G (1996) History of migraine and risk of cerebral ischaemia in young adults The Italian National Research Council Study Group on Stroke in the Young. Lancet 347:1503–1506

    PubMed  CAS  Google Scholar 

  23. Chang CL, Donaghy M, Poulter N (1999) Migraine and stroke in young women: case-control study The World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Br Med J 318:13–18

    CAS  Google Scholar 

  24. Chen TC, Leviton A, Edelstein S, Ellenberg JH (1987) Migraine and other diseases in women of reproductive age. The influence of smoking on observed associations. Arch Neurol 44:1024–1028

    PubMed  CAS  Google Scholar 

  25. Collaborative Group for the Study of Stroke in Young Women (1975) Oral contraceptives and stroke in young women: associated risk factors. JAMA 231:718–722

  26. Cook NR, Bensenor IM, Lotufo PA, Lee IM, Skerrett PJ, Chown MJ, Ajana UA, Manson JE, Buring JE (2002) Migraine and coronary heart disease in women and men. Headache 42:715–727

    Article  PubMed  Google Scholar 

  27. Dalla Volta G, Magoni M, Guidani M, Zavarise P, Griffini S, Pezzini A, Padovani A (2005) Prevalence of patent foramen ovale in a large series of patients with migraine with aura, migraine without aura and cluster headache, and relationship with clinical phenotype. J Headache Pain 6:328–330

    Article  PubMed  Google Scholar 

  28. Davey G, Sedgwick P, Maier W, Visick G, Strachan DP, Anderson HR (2002) Association between migraine and asthma: matched case-control study. Br J Gen Pract 52:723–727

    PubMed  Google Scholar 

  29. Del Sette M, Angeli S, Leandri M, Ferriero G, Bruzzone GL, Finocchi C, Gandolfo C (1998) Migraine with aura and right-to-left shunt on transcranial Doppler: a case-control study. Cerebrovasc Dis 8:327–330

    Article  PubMed  CAS  Google Scholar 

  30. Diener HC, Hartung E, Chrubasik J, Evers S, Schoenen J, Eikermann A, Latta G, Hauke W (2001) A comparative study of oral acetylsalicyclic acid and metoprolol for the prophylactic treatment of migraine. A randomized, controlled, double-blind, parallel group phase III study. Cephalalgia 21:120–128

    Article  PubMed  CAS  Google Scholar 

  31. Diener HC (2006) Primary and secondary stroke prevention with antiplatelet drugs. Curr Pharm Dess 12:1293–1297

    Article  CAS  Google Scholar 

  32. Donaghy M, Chang CL, Poulter N (2002) Duration, frequency, recency, and type of migraine and the risk of ischaemic stroke in women of child bearing age. J Neurol Neurosurg Psychiatry 73:747–750

    Article  PubMed  CAS  Google Scholar 

  33. Dowson AJ, Wilmshurst P, Muir KW, Mullen M, Nightingale S, MIST Study Investigators (2005) A prospective, multicentre, double-blind, placebo-controlled study to evaluate the efficacy of patent foramen ovale closure for the resolution of refractory migraine headache (the MIST Study): prevalence and size of shunts. Headache Care 2:223–227

    Article  Google Scholar 

  34. Dowson A, Mullen MJ, Peatfield R, Muir K, Khan AA, Wells C, Lipscombe SL, Rees T, De Giovanni JV, Morrison WL, Hildick-Smith D, Elrington G, Hillis WS, Malik IS, Rickards A. (2008) Migraine intervention with STARFlex Technology (MIST) trial: a prospective, multicenter, double blind, sham-controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headaches. Circulation 117:1397–1404

    Article  PubMed  Google Scholar 

  35. Etminan M, Takkouche B, Isorna FC, Samii A (2005) Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. Br Med J 330:63–65

    Article  Google Scholar 

  36. Furman JM, Marcus DA, Balaban CD (2006) Migrainous vertigo: development of a pathogenetic model and structured diagnostic interview. Curr Opin Neurol 16:5–13

    Article  Google Scholar 

  37. Garcia-Albea E, Abarca M (1993) Migraine and acute myocardial infarction. Neurologia 8:209–211

    PubMed  CAS  Google Scholar 

  38. Gudmundsson LS, Thorgeirsson G, Sigfusson N, Sigvaldason H, Johanns son M (2006) Migraine patients have lower systolic but higher diastolic blood pressure compared with controls in a population-based study of 21,537 subjects. The Reykjavik Study. Cephalalgia 26:436–444

    Article  PubMed  CAS  Google Scholar 

  39. Haapaniemi H, Hillbom M, Juvela S (1997) Lifestyle-associated risk factors for acute brain infarction among persons of working age. Stroke 28:26–33

    PubMed  CAS  Google Scholar 

  40. Hall GC, Brown MM, Mo J, MacRae KD (2004) Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology 62:563–568

    PubMed  CAS  Google Scholar 

  41. Henrich JB, Horwitz RI (1989) A controlled study of ischemic stroke risk in migraine patients. J Clin Epidemiol 42:773–780

    Article  PubMed  CAS  Google Scholar 

  42. Hung CI, Liu CY, Juang YY, Wang SJ (2006) The impact of migraine on patients with major depressive disorder. Headache 46:469–477

    Article  PubMed  Google Scholar 

  43. Kothare SV (2005) Efficacy of flunarizine in the prophylaxis of cyclical vomiting syndrome and abdominal migraine. Eur J Paediatr Neurol 9:23–26

    Article  PubMed  Google Scholar 

  44. Kruit MC, Launer LJ, Ferrari MD, van Buchem MA (2006) Brain stem and cerebellar hyperintense lesions in migraine. Stroke 37:1109–1112

    Article  PubMed  Google Scholar 

  45. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ (2004) Migraine as a risk factor for subclinical brain lesions. JAMA 291:427–434

    Article  PubMed  CAS  Google Scholar 

  46. Kurth T, Gaziano JM, Cook N, Bubes V, Logroscino G, Diener HC, Buring JE (2007) Migraine and risk of cardiovascular disease in men. Arch Intern Med 167:795–801

    Article  PubMed  Google Scholar 

  47. Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291

    Article  PubMed  CAS  Google Scholar 

  48. Kurth T, Holtmann G, Neufang-Huber J, Gerken G, Diener HC (2006) Prevalence of unexplained upper abdominal symptoms in patients with migraine. Cephalalgia 26:506–510

    Article  PubMed  CAS  Google Scholar 

  49. Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, Diener HC, Buring JE (2005) Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 64:1020–1026

    PubMed  CAS  Google Scholar 

  50. Lafitte C, Even C, Henry-Lebras F, de Toffol B, Autret A (1996) Migraine and angina pectoris by coronary artery spasm. Headache 36:332–334

    Article  PubMed  CAS  Google Scholar 

  51. Lampl C, Bonelli S, Ransmayr G (2004) Efficacy of topiramate in migraine aura prophylaxis: preliminary results of 12 patients. Headache 44:174–177

    Article  PubMed  Google Scholar 

  52. Lampl C, Katsarava Z, Diener HC, Limmroth V (2005) Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. J Neurol Neurosurg Psychiatry 76:1730–1732

    Article  PubMed  CAS  Google Scholar 

  53. Leniger T, von den Driesch S, Isbruch K, Diener H, Hufnagel A (2003) Clinical characteristics of patients with comorbidity of migraine and epilepsy. Headache 43:672–677

    Article  PubMed  Google Scholar 

  54. Ludvigsson P, Hesdorffer D, Olafsson E, Kjartansson O, Hauser WA (2006) Migraine with aura is a risk factor for unprovoked seizures in children. Ann Neurol 59:210–213

    Article  PubMed  Google Scholar 

  55. Mac Clellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, Kittner SJ (2007) Probable migraine with visual aura and risk of ischemic stroke: the stroke prevention in young women study. Stroke 38:2438–2445

    Article  Google Scholar 

  56. Maione A (2006) Migraine-related vertigo: diagnostic criteria and prophylactic treatment. Laryngoscope 116:1782–1786

    Article  PubMed  Google Scholar 

  57. Marcus DA, Furman JM (2006) Prevention of motion sickness with rizatrip tan: a double-blind, placebo-controlled pilot study. Med Sci Monit 12:PI1–PI7

    PubMed  CAS  Google Scholar 

  58. Marini C, Carolei A, Roberts R, Prencipe M, Gandolfo C, Inzitari D, Landi G, De Zanche L, Scoditti U, Fieschi C (1993) Focal cerebral ischemia in young adults: a collaborative case-control study. The National Research Council Study Group. Neuroepidemiology 12:70–81

    Article  PubMed  CAS  Google Scholar 

  59. Marks DA, Ehrenberg BL (1993) Migraine-related seizures in adults with epilepsy, with EEG correlation. Neurology 43:2476–2483

    PubMed  CAS  Google Scholar 

  60. Mattioli AV, Bonetti L, Aquilina M, Oldani A, Longhini C, Mattioli G, Atrial Septal Aneurysm Multicenter Italian Study Investigators (2003) The association between atrial septal aneurysm and mitral valve prolapse in patients with recent stroke and normal carotid arteries. Ital Heart J 4:602–606

    PubMed  Google Scholar 

  61. McWilliams LA, Goodwin RD, Cox BJ (2004) Depression and anxiety associated with three pain conditions: results from a nationally representative sample. Pain 111:77–83

    Article  PubMed  Google Scholar 

  62. Merikangas KR (1996) Genetics of migraine and other headache. Current Opinion in Neurology 9:202–205

    Article  PubMed  CAS  Google Scholar 

  63. Merikangas KR, Fenton BT, Cheng SH, Stolar MJ, Risch N (1997) Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol 54:362–368

    PubMed  CAS  Google Scholar 

  64. Merikangas KR, Stevens DE (1997) Comorbidity of migraine and psychiatric disorders. Neurological Clinics of North America 15:115–123

    CAS  Google Scholar 

  65. Meucci G, Radaelli F, Prada A, Bortoli A, Crotta S, Cerrato C, Minoli G (2005) Increased prevalence of migraine in patients with uninvestigated dyspepsia referred for open-access upper gastrointestinal endoscopy. Endoscopy 37:622–625

    Article  PubMed  CAS  Google Scholar 

  66. Milhaud D, Bogousslavsky J, van Melle G, Liot P (2001) Ischemic stroke and active migraine. Neurology 57:1805–1811

    PubMed  CAS  Google Scholar 

  67. Mitchell P, Wang JJ, Currie J, Cumming RG, Smith W (1998) Prevalence and vascular associations with migraine in older Australians. Aust N Z J Med 28:627–632

    PubMed  CAS  Google Scholar 

  68. Moldin SO, Scheftner WA, Rice JP, Nelson E, Knesevich MA, Akiskal H (1993) Association between major depressive disorder and physical illness. Psychol Med 23:755–761

    Article  PubMed  CAS  Google Scholar 

  69. Montgomery SA (1995) Safety of mirtazapine: a review. Int Clin Psychopharmacol 10(Suppl 4):37–45

    Article  PubMed  Google Scholar 

  70. Mortelmans K, Post M, Thijs V, Herroelen L, Budts W (2005) The influence of percutaneous atrial septal defect closure on the occurrence of migraine. Eur Heart J 26:1533–1537

    Article  PubMed  Google Scholar 

  71. Neuhauser HK (2007) Epidemiology of vertigo. Curr Opin Neurol 20:40–46

    Article  PubMed  Google Scholar 

  72. Neuhauser HK, Radtke A, von Brevern M, Feldmann M, Lezius F, Ziese T, Lempert T (2006) Migrainous vertigo: prevalence and impact on quality of life. Neurology 67:1028–1033

    Article  PubMed  CAS  Google Scholar 

  73. Nightingale A, Farmer R (2004) Ischemic stroke in young women: a nested case-control study using the UK General Practice Research Database. Stroke 35:1574–1578

    Article  PubMed  Google Scholar 

  74. Oedegaard KJ, Neckelmann D, Mykletun A, Dahl AA, Zwart JA, Hagen K, Fasmer OB (2006) Migraine with and without aura: association with depression and anxiety disorder in a population-based study. The HUNT Study. Cephalalgia 26:1–6

    Article  PubMed  CAS  Google Scholar 

  75. Oosterveld WJ (1982) Flunarizine in vertigo. A double-blind placebo-controlled cross-over evaluation of a constant-dose schedule. ORL J Otorhinolaryngol Relat Spec 44:72–80

    PubMed  CAS  Google Scholar 

  76. Ottman R, Lipton RB (1996) Is the comorbidity of epilepsy and migraine due to a shared genetic susceptibility? Neurology 47:918–924

    PubMed  CAS  Google Scholar 

  77. Ozyalcin SN, Talu GK, Kiziltan E, Yucel B, Ertas M, Disci R (2005) The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache 45:144–152

    Article  PubMed  Google Scholar 

  78. Pierangeli G, Cevoli S, Zanigni S, Sancisi E, Monaldini C, Donti A, Ribani MA, Montagna P, Cortelli P (2004) The role of cardiac diseases in the co morbidity between migraine and stroke. Neurol Sci 25(Suppl 3):S129–S131

    Article  PubMed  Google Scholar 

  79. Post M, Thijs V, Herroelen L, Budts W (2004) Closure of a patent foramen ovale is associated with a decrease in prevalence of migraine. Neurology 62:1439–1440

    PubMed  Google Scholar 

  80. Reisman M, Christofferson RD, Jesurum J, Olsen JV, Spencer MP, Krabill KA, Diehl L, Aurora S, Gray WA (2005) Migraine headache relief after transcatheter closure of patent foramen ovale. J Am Coll Cardiol 45:493–495

    Article  PubMed  Google Scholar 

  81. Rosamond W (2004) Are migraine and coronary heart disease associated? An epidemiologic review. Headache 44:S5–S12

    Article  PubMed  Google Scholar 

  82. Rose KM, Carson AP, Sanford CP, Stang PE, Brown CA, Folsom AR, Szklo M (2004) Migraine and other headaches: associations with Rose angina and coronary heart disease. Neurology 63:2233–2239

    PubMed  CAS  Google Scholar 

  83. Scher AI, Bigal ME, Lipton RB (2005) Comorbidity of migraine. Curr Opin Neurol 18:305–310

    Article  PubMed  Google Scholar 

  84. Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614–620

    PubMed  CAS  Google Scholar 

  85. Schrader H, Stovner LJ, Helde G, Sand T, Bovim G (2001) Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomised, placebo-controlled, crossover trial. BMJ 322:19–22

    Article  PubMed  CAS  Google Scholar 

  86. Schwaag S, Nabavi DG, Frese A, Husstedt IW, Evers S (2003) The association between migraine and juvenile stroke: a case-control study. Headache 43:90–95

    Article  PubMed  Google Scholar 

  87. Schwerzmann M, Nedeltchev K, Lagger F, Mattle HP, Windecker S, Meier B, Seiler C (2005) Prevalence and size of directly detected patent foramen ovale in migraine with aura. Neurology 65:1415–1418

    Article  PubMed  CAS  Google Scholar 

  88. Schwerzmann M, Wiher S, Nedeltchev K, Mattle HP, Wahl A, Seiler C, Meier B, Windecker S (2004) Percutaneous closure of patent foramen ovale reduces the frequency of migraine attacks. Neurology 62:1399–1401

    PubMed  CAS  Google Scholar 

  89. Seemungal B, Rudge P, Davies R, Gresty M, Bronstein A (2006) Three patients with migraine following caloric-induced vestibular stimulation. J Neurol 253:1000–1001

    Article  PubMed  Google Scholar 

  90. Sharifi M, Burks J (2004) Efficacy of clopidogrel in the treatment of post-ASD closure migraines. Catheter Cardiovasc Interv 63:255

    Article  PubMed  Google Scholar 

  91. Sheftell F, Rapoport A, Weeks R, Walker B, Gammerman I, Baskin S (2000) Montelukast in the prophylaxis of migraine: a potential role for leukotriene modifiers. Headache 40:158–163

    Article  PubMed  CAS  Google Scholar 

  92. Stang PE, Carson AP, Rose KM, Mo J, Ephross SA, Shahar E, Szklo M (2005) Headache, cerebrovascular symptoms, and stroke: the Atherosclerosis Risk in Communities Study. Neurology 64:1573–1577

    Article  PubMed  CAS  Google Scholar 

  93. Sternfeld B, Stang P, Sidney S (1995) Relationship of migraine headaches to experience of chest pain and subsequent risk for myocardial infarction. Neurology 45:2135–2142

    PubMed  CAS  Google Scholar 

  94. Stewart AL, Greenfield S, Hays RD, Wells K, Rogers WH, Berry SD, McGlynn EA, Ware JE Jr (1989) Functional status and well-being of patients with chronic conditions – results from the Medical Outcomes Study. JAMA 262:907–913

    Article  PubMed  CAS  Google Scholar 

  95. Theoharides TC, Donelan J, Kandere- Grzybowska K, Konstantinidou A (2005) The role of mast cells in migraine pathophysiology. Brain Res Brain Res Rev 49:65–76

    Article  PubMed  CAS  Google Scholar 

  96. Thijs RD, Kruit MC, van Buchem MA, Ferrari MD, Launer LJ, van Dijk JG (2006) Syncope in migraine: the population-based CAMERA study. Neurology 66:1034–1037

    Article  PubMed  CAS  Google Scholar 

  97. Tietjen GE, Brandes JL, Digre KB, Baggaley S, Martin V, Recober A, Geweke LO, Hafeez F, Aurora SK, Herial NA, Utley C, Khuder SA (2007) High prevalence of somatic symptoms and depression in women with disabling chronic headache. Neurology 68:134–140

    Article  PubMed  CAS  Google Scholar 

  98. Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G (2002) Prophylactic treatment of migraine with an angiotensin II receptor blocker. A randomized controlled trial. JAMA 289:65–69

    Article  Google Scholar 

  99. Tzourio C, Iglesias S, Hubert JB, Visy JM, Alperovitch A, Tehindrazanarivelo A, Biousse V, Woimant F, Bousser MG (1993) Migraine and risk of ischaemic stroke: a case-control study. BMJ 307:289–292

    PubMed  CAS  Google Scholar 

  100. Tzourio C, Tehindrazanarivelo A, Iglesias S, Alperovitch A, Chedru F, d‘Anglejan-Chatillon J, Bousser MG (1995) Case-control study of migraine and risk of ischaemic stroke in young women. BMJ 310:830–833

    PubMed  CAS  Google Scholar 

  101. Uyarel H, Erden I, Cam N (2005) Acute migraine attack, angina-like chest pain with documented ST-segment elevation and slow coronary flow. Acta Cardiol 60:221–223

    Article  PubMed  Google Scholar 

  102. Vanmolkot KR, Babini E, de Vries B, Stam AH, Freilinger T, Terwindt GM, Norris L, Haan J, Frants RR, Ramadan NM, Ferrari MD, Pusch M, van den Maagdenberg AM, Dichgans M (2007) The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online. Hum Mutat 28:522

    Article  PubMed  Google Scholar 

  103. Velentgas P, Cole JA, Mo J, Sikes CR, Walker AM (2004) Severe vascular events in migraine patients. Headache 44:642–651

    Article  PubMed  Google Scholar 

  104. Velioglu SK, Boz C, Ozmenoglu M (2005) The impact of migraine on epilepsy: a prospective prognosis study. Cephalalgia 25:528–535

    Article  PubMed  CAS  Google Scholar 

  105. Velioglu SK, Ozmenoglu M (1999) Migraine-related seizures in an epileptic population. Cephalalgia 19:797–801

    Article  PubMed  CAS  Google Scholar 

  106. von Brevern M, Ta N, Shankar A, Wiste A, Siegel A, Radtke A, Sander T, Escayg A (2006) Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4. Headache 46:1136–1141

    Article  PubMed  Google Scholar 

  107. von Brevern M, Zeise D, Neuhauser H, Clarke AH, Lempert T (2005) Acute migrainous vertigo: clinical and oculographic findings. Brain 128:365–374

    Article  PubMed  Google Scholar 

  108. Wayne VS (1986) A possible relationship between migraine and coronary artery spasm. Aust N Z J Med 16:708–710

    PubMed  CAS  Google Scholar 

  109. Wilmshurst PT, Nightingale S, Walsh KP, Morrison WL (2000) Effect on migraine of closure of cardiac right-to-left shunts to prevent recurrence of decompression illness or stroke or for haemodynamic reasons. Lancet 356:1648–1651

    Article  PubMed  CAS  Google Scholar 

  110. Wilmshurst PT, Nightingale S, Walsh KP, Morrison WL (2005) Clopidogrel reduces migraine with aura after transcatheter closure of persistent foramen ovale and atrial septal defects. Heart 91:1173–1175

    Article  PubMed  CAS  Google Scholar 

  111. Wilmshurst PT, Pearson MJ, Nightingale S, Walsh KP, Morrison WL (2004) Inheritance of persistent foramen ovale and atrial septal defects and the relation to familial migraine with aura. Heart 90:1315–1320

    Article  PubMed  CAS  Google Scholar 

  112. Zissis NP, Harmoussi S, Vlaikidis N, Mitsikostas D, Thomaidis T, Georgiadis G, Karageorgiou K (2007) A randomized, double-blind, placebo-controlled study of venlafaxine XR in out-patients with tension-type headache. Cephalalgia 27:315–324

    Article  PubMed  CAS  Google Scholar 

  113. Zwart J, Dyb G, Hagen K, Odegard K, Dahl A, Bovim G, Stovner LJ (2003) Depression and anxiety disorders associated with headache frequency. The Nord-Trondelag Health Study. Eur J Neurol 10:147–152

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dept. of Neurology and Headache Center, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany

    H. C. Diener & M. Küper

  2. Divisions of Aging and Preventive Medicine, Dept. of Medicine, Brigham and Women’s Hospital, and Dept. of Epidemiology Harvard School of Public Health, Boston, MA, USA

    T. Kurth

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  1. H. C. Diener
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  2. M. Küper
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  3. T. Kurth
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Correspondence to H. C. Diener.

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Conflict of interest Prof. Dr. Hans-Christoph Diener received honoraria for participation in clinical trials, contribution to advisory boards or oral presentations from:

Addex Pharma, Allergan, Almirall, AstraZeneca, Bayer Vital, Berlin Chemie, CoLucid, Böhringer Ingelheim, Bristol-Myers Squibb, Glaxo-SmithKline, Grünenthal, Janssen-Cilag, Lilly, La Roche, 3M Medica, MSD, Novartis, Johnson & Johnson, Pierre Fabre, Pfizer, Schaper and Brümmer, SanofiAventis, Weber & Weber.

Financial support for research projects was provided by Allergan, Almirall, Astra-Zeneca, Bayer, GSK, Janssen-Cilag, Pfizer.

Headache research at the Department of Neurology in Essen is supported by the German Research Group (DFG), the German Ministry of Education and Research (BMBF) and the European Union.

H. C. Diener has no ownership interest and does not own stocks of any pharmaceutical company.

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Diener, H.C., Küper, M. & Kurth, T. Migraine-associated risks and comorbidity. J Neurol 255, 1290–1301 (2008). https://doi.org/10.1007/s00415-008-0984-6

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  • DOI: https://doi.org/10.1007/s00415-008-0984-6

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