Abstract
Background
Acute exacerbations (AE) of idiopathic pulmonary fibrosis (IPF) are well recognized in the progression of this uniformly fatal disease. Surgical lung biopsy and lung resection may initiate these acute events leading to a rapid deterioration and permanent decline in lung function. Our aim is to discuss the role of pulmonary and nonpulmonary surgery as a precipitating factor and to review the literature on the nature, course, and outcomes of acute exacerbations in the context of surgical interventions.
Methods
This study consisted of a retrospective case series of patients at the Johns Hopkins Hospital who experienced acute exacerbation following a surgical procedure. Patients included in the case series suffered from aggravation of dyspnea within 1 month after surgical intervention, with new infiltrates on imaging. There was no other more likely cause after diagnostic evaluation. A comprehensive review of the current literature pertaining to AEs of IPF in the context of a surgical intervention was performed.
Results
In a series of four patients from Johns Hopkins Hospital with AE in IPF, two of three patients who underwent video-assisted thoracoscopic surgery (VATS) lung biopsy had a fatal outcome. The fourth patient survived an AE after a total knee replacement but had a fatal outcome after a subsequent coronary artery bypass graft surgery. We found no report in the literature of AE in an IPF patient who underwent nonpulmonary surgery.
Conclusions
Acute exacerbations of IPF can occur postoperatively after both pulmonary and nonpulmonary surgery and are associated with a high mortality rate. As a next step, a prospective multicenter clinical study of patients with IPF undergoing both pulmonary and nonpulmonary surgeries would allow the identification of perioperative risk factors in the development of AE of IPF.
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Abbreviations
- AE:
-
Acute exacerbation
- IPF:
-
Idiopathic pulmonary fibrosis
- VATS:
-
Video assisted thoracoscopic surgery
- ICU:
-
Intensive care unit
- ALI/ARDS:
-
Acute lung injury/acute respiratory distress syndrome
- CF:
-
Circulating fibrocytes
- TKR:
-
Total knee replacement
References
American Thoracic Society (2000) Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS) and the European Respiratory Society (ERS). Am J Respir Crit Care Med 161:646–664
American Thoracic Society; European Respiratory Society (2002) American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 165:277–304
Watanabe A, Kawaharada N, Higami T (2011) Postoperative acute exacerbation of IPF after lung resection for primary lung cancer. Pulm Med 2011:960316
Kondoh Y, Taniguchi H, Kitaichi M, Yokoi T, Johkoh T, Oishi T et al (2006) Acute exacerbation of interstitial pneumonia following surgical lung biopsy. Respir Med 100:1753–1759
Kim DS, Park JH, Park BK, Lee JS, Nicholson AG, Colby T (2006) Acute exacerbation of idiopathic pulmonary fibrosis: frequency and clinical features. Eur Respir J 27:143–150
Sigurdsson MI, Isaksson HJ, Gudmundsson G, Gudbjartsson T (2009) Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study. Ann Thorac Surg 88(1):227–232
Park JH, Kim DK, Kim DS, Koh Y, Lee SD, Kim WS, Kim WD, Park SI (2007) Mortality and risk factors for surgical lung biopsy in patients with idiopathic interstitial pneumonia. Eur J Cardiothorac Surg 31:1115–1119
Kreider ME, Hansen-Flaschen J, Ahmad NN, Rossman MD, Kaiser LR, Kucharczuk JC, Shrager JB (2007) Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease. Ann Thorac Surg 83(3):1140–1144
Utz JP, Ryu JH, Douglas WW et al (2001) High short-term mortality following lung biopsy for usual interstitial pneumonia. Eur Respir J 17:175–179
Tiitto L, Heiskanen U, Bloigu R et al (2005) Thoracoscopic lung biopsy is a safe procedure in diagnosing usual interstitial pneumonia. Chest 128:2375–2380
Lettieri CJ, Veerappan GR, Helman DL, Mulligan CR, Shorr AF (2005) Outcomes and safety of surgical lung biopsy for interstitial lung disease. Chest 127:1600–1605
Suzuki H, Sekine Y, Yoshida S, Suzuki M et al (2011) Risk of acute exacerbation of interstitial pneumonia after pulmonary resection for lung cancer in patients with idiopathic pulmonary fibrosis based on preoperative high-resolution computed tomography. Surg Today 41:914–921
Shintani Y, Ohta M, Iwasaki T, Ikeda N, Tomita E, Kawahara K, Ohno Y (2010) Predictive factors for postoperative acute exacerbation of interstitial pneumonia combined with lung cancer. Gen Thorac Cardiovasc Surg 58(4):182–185
Kushibe K, Kawaguchi T, Takahama M, Kimura M, Tojo T, Taniguchi S (2007) Operative indications for lung cancer with idiopathic pulmonary fibrosis. J Thorac Cardiovasc Surg 55(8):505–508
Watanabe A, Higami T, Ohori S, Koyanagi T, Nakashima S, Mawatari T (2008) Is lung cancer resection indicated in patients with idiopathic pulmonary fibrosis? J Thorac Cardiovasc Surg 136(5):1357–1363
Kawasaki H, Nagai K, Yoshida J, Nishimura M, Nishiwaki Y (2002) Postoperative morbidity, mortality, and survival in lung cancer associated with idiopathic pulmonary fibrosis. J Surg Oncol 81(1):33–37
Saydain G, Islam A, Afessa B et al (2002) Outcome of patients with idiopathic pulmonary fibrosis admitted to the intensive care unit. Am J Respir Crit Care Med 166:839–842
Al-Hameed FM, Sharma S (2004) Outcome of patients admitted to the intensive care unit for acute exacerbation of idiopathic pulmonary fibrosis. Can Respir J 11:117–122
Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1(1):71–81
Strieter RM, Keeley EC, Burdick MD, Mehrad B (2009) The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis. Trans Am Clin Climatol Assoc 120:49–59
Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R (2004) Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 36(4):598–606
Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA, Keane MP, Strieter RM (2004) Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 114(3):438–446
Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S (2003) Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 171(1):380–389
Chauhan H, Abraham A, Phillips JR, Pringle JH, Walker RA, Jones JL (2003) There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions. J Clin Pathol 56(4):271–276
Moeller A, Gilpin SE, Ask K, Cox G, Cook D, Gauldie J, Margetts PJ, Farkas L, Dobranowski J, Boylan C, O’Byrne PM, Strieter RM, Kolb M (2009) Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 179(7):588–594
Kubo H, Nakayama K, Yanai M, Suzuki T, Yamaya M, Watanabe M, Sasaki H (2005) Anticoagulant therapy for idiopathic pulmonary fibrosis. Chest 128(3):1475–1482
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A. Ghatol and A. P. Ruhl contributed equally to this work and share first authorship.
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Ghatol, A., Ruhl, A.P. & Danoff, S.K. Exacerbations in Idiopathic Pulmonary Fibrosis Triggered by Pulmonary and Nonpulmonary Surgery: A Case Series and Comprehensive Review of the Literature. Lung 190, 373–380 (2012). https://doi.org/10.1007/s00408-012-9389-5
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DOI: https://doi.org/10.1007/s00408-012-9389-5