Skip to main content

Advertisement

SpringerLink
Log in

Interleukin-12 Receptor β1 Polymorphisms and Nontuberculous Mycobacterial Lung Diseases

  • Published:
Lung Aims and scope Submit manuscript

Abstract

The pathway involving interferon-γ and interleukin (IL)-12 plays an important role in host defense against mycobacterial infections. Recent studies have indicated that IL-12 receptor β1 (IL-12Rβ1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis. However, there have been no reports of an association between IL-12Rβ1 gene polymorphism and lung disease caused by nontuberculous mycobacteria (NTM). The present study involved 128 patients with the nodular bronchiectatic form of NTM lung disease (75 patients with Mycobacterium avium-intracellulare complex infection and 53 patients with Mycobacterium abscessus infection) and 240 healthy controls. Single nucleotide polymorphisms of the IL-12Rβ1 gene at positions +705A/G, +1158T/C, and +1196G/C were determined by direct sequencing of polymerase chain reaction products. Comparisons of the NTM lung disease patients with healthy controls did not identify any significant differences in relation to the genotype, allele, and haplotype frequencies of the IL-12Rβ1 +705A/G, +1158T/C, and +1196G/C polymorphisms. These IL-12Rβ1 gene polymorphisms do not appear to be responsible for host susceptibility to NTM lung disease, at least in this Korean population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wallace RJ Jr, Cook JL, Glassroth J, Griffith DE, Olivier KN, Gordin F (1997) American Thoracic Society statement: diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am J Respir Crit Care Med 156:S1–S25

    Article  Google Scholar 

  2. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, Iseman M, Olivier K, Ruoss S, von Reyn CF, Wallace RJ Jr, Winthrop K, ATS Mycobacterial Diseases Subcommittee, American Thoracic Society, Infectious Disease Society of America (2007) An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 175:367–416

    Article  CAS  PubMed  Google Scholar 

  3. Koh WJ, Kwon OJ, Lee KS (2005) Diagnosis and treatment of nontuberculous mycobacterial pulmonary diseases: a Korean perspective. J Korean Med Sci 20:913–925

    Article  PubMed  PubMed Central  Google Scholar 

  4. Koh WJ, Lee KS, Kwon OJ, Jeong YJ, Kwak SH, Kim TS (2005) Bilateral bronchiectasis and bronchiolitis at thin-section CT: diagnostic implications in nontuberculous mycobacterial pulmonary infection. Radiology 235:282–288

    Article  PubMed  Google Scholar 

  5. Chung MJ, Lee KS, Koh WJ, Lee JH, Kim TS, Kwon OJ, Kim S (2005) Thin-section CT findings of nontuberculous mycobacterial pulmonary diseases: comparison between Mycobacterium avium-intracellulare complex and Mycobacterium abscessus infection. J Korean Med Sci 20:777–783

    Article  PubMed  PubMed Central  Google Scholar 

  6. Chung MJ, Lee KS, Koh WJ, Kim TS, Kang EY, Kim SM, Kwon OJ, Kim S (2006) Drug-sensitive tuberculosis, multidrug-resistant tuberculosis, and nontuberculous mycobacterial pulmonary disease in nonAIDS adults: comparisons of thin-section CT findings. Eur Radiol 16:1934–1941

    Article  PubMed  Google Scholar 

  7. Koh WJ, Yu CM, Suh GY, Chung MP, Kim H, Kwon OJ, Lee NY, Chung MJ, Lee KS (2006) Pulmonary TB and NTM lung disease: comparison of characteristics in patients with AFB smear-positive sputum. Int J Tuberc Lung Dis 10:1001–1007

    CAS  PubMed  Google Scholar 

  8. Guide SV, Holland SM (2002) Host susceptibility factors in mycobacterial infection. Genetics and body morphotype. Infect Dis Clin North Am 16:163–186

    Article  PubMed  Google Scholar 

  9. Koh WJ, Kwon OJ, Kim EJ, Lee KS, Ki CS, Kim JW (2005) NRAMP1 gene polymorphism and susceptibility to nontuberculous mycobacterial lung diseases. Chest 128:94–101

    Article  CAS  PubMed  Google Scholar 

  10. Mai HN, Hijikata M, Inoue Y, Suzuki K, Sakatani M, Okada M, Kimura K, Kobayashi N, Toyota E, Kudo K, Nagai H, Kurashima A, Kajiki A, Oketani N, Hayakawa H, Tanaka G, Shojima J, Matsushita I, Sakurada S, Tokunaga K, Keicho N (2007) Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 allele of the CFTR gene. Int J Tuberc Lung Dis 11:808–813

    CAS  PubMed  Google Scholar 

  11. Rosenzweig SD, Holland SM (2005) Defects in the interferon-γ and interleukin-12 pathways. Immunol Rev 203:38–47

    Article  CAS  PubMed  Google Scholar 

  12. Kwon YS, Kim EJ, Lee SH, Suh GY, Chung MP, Kim H, Kwon OJ, Koh WJ (2007) Decreased cytokine production in patients with nontuberculous mycobacterial lung disease. Lung 185:337–341

    Article  CAS  PubMed  Google Scholar 

  13. Akahoshi M, Nakashima H, Miyake K, Inoue Y, Shimizu S, Tanaka Y, Okada K, Otsuka T, Harada M (2003) Influence of interleukin-12 receptor β1 polymorphisms on tuberculosis. Hum Genet 112:237–243

    CAS  PubMed  Google Scholar 

  14. Remus N, El Baghdadi J, Fieschi C, Feinberg J, Quintin T, Chentoufi M, Schurr E, Benslimane A, Casanova JL, Abel L (2004) Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in Morocco. J Infect Dis 190:580–587

    Article  CAS  PubMed  Google Scholar 

  15. Lee SB, Kim BC, Jin SH, Park YG, Kim SK, Kang TJ, Chae GT (2003) Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. Immunogenetics 55:177–181

    Article  CAS  PubMed  Google Scholar 

  16. Lee HW, Lee HS, Kim DK, Ko DS, Han SK, Shim YS, Yim JJ (2005) Lack of an association between interleukin-12 receptor β1 polymorphisms and tuberculosis in Koreans. Respiration 72:365–368

    Article  CAS  PubMed  Google Scholar 

  17. Doherty TM, Sher A (1998) IL-12 promotes drug-induced clearance of Mycobacterium avium infection in mice. J Immunol 160:5428–5435

    CAS  PubMed  Google Scholar 

  18. Silva RA, Pais TF, Appelberg R (1998) Evaluation of IL-12 in immunotherapy and vaccine design in experimental Mycobacterium avium infections. J Immunol 161:5578–5585

    CAS  PubMed  Google Scholar 

  19. Vankayalapati R, Wizel B, Samten B, Griffith DE, Shams H, Galland MR, Von Reyn CF, Girard WM, Wallace RJ Jr, Barnes PF (2001) Cytokine profiles in immunocompetent persons infected with Mycobacterium avium complex. J Infect Dis 183:478–484

    Article  CAS  PubMed  Google Scholar 

  20. Trinchieri G (1994) Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008–4027

    CAS  PubMed  Google Scholar 

  21. Caragol I, Raspall M, Fieschi C, Feinberg J, Larrosa MN, Hernández M, Figueras C, Bertrán JM, Casanova JL, Español T (2003) Clinical tuberculosis in 2 of 3 siblings with interleukin-12 receptor β1 deficiency. Clin Infect Dis 37:302–306

    Article  CAS  PubMed  Google Scholar 

  22. de Jong R, Altare F, Haagen IA, Elferink DG, Boer T, van Breda Vriesman PJ, Kabel PJ, Draaisma JM, van Dissel JT, Kroon FP, Casanova JL, Ottenhoff TH (1998) Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 280:1435–1438

    Article  PubMed  Google Scholar 

  23. Delgado JC, Baena A, Thim S, Goldfeld AE (2002) Ethnic-specific genetic associations with pulmonary tuberculosis. J Infect Dis 186:1463–1468

    Article  CAS  PubMed  Google Scholar 

  24. Ioannidis JP, Ntzani EE, Trikalinos TA (2004) ‘Racial’ differences in genetic effects for complex diseases. Nat Genet 36:1312–1318

    Article  CAS  PubMed  Google Scholar 

  25. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177–182

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A060256).

Author information

Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea

    Hye Yun Park, Yong Soo Kwon, Gee Young Suh, Man Pyo Chung, Hojoong Kim, O. Jung Kwon & Won-Jung Koh

  2. Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Chang-Seok Ki

Authors
  1. Hye Yun Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yong Soo Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chang-Seok Ki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gee Young Suh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Man Pyo Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hojoong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. O. Jung Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Won-Jung Koh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Won-Jung Koh.

Additional information

H. Y. Park and Y. S. Kwon contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Park, H.Y., Kwon, Y.S., Ki, CS. et al. Interleukin-12 Receptor β1 Polymorphisms and Nontuberculous Mycobacterial Lung Diseases. Lung 186, 241–245 (2008). https://doi.org/10.1007/s00408-008-9096-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00408-008-9096-4

Keywords

Search

Navigation