Abstract
There is a pressing need for effective treatments that address the high rate of suicide observed among people with psychosis. In this scoping review we highlight two suicidogenic treatment targets that have been relatively neglected in people with psychotic disorders: emotional distress and emotion dysregulation. We review the research on these constructs in psychosis and their relationship to suicide in this population, and then make clinical recommendations based on research findings. Emotional distress and emotional dysregulation may be promising treatment targets for suicide among people with psychosis.
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References
Hor K, Taylor M (2010) Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol 24:81–90
Bertolote JM, Fleischmann A (2002) Suicide and psychiatric diagnosis: a worldwide perspective. World Psychiatry 1:181–185
Olfson M, Gerhard T, Huang C et al (2015) Premature mortality among adults with schizophrenia in the United States. JAMA Psychiat 72:1172–1181
Saha S, Chant D, McGrath J (2007) A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 64:1123–1131
Beautrais AL (2001) Suicides and serious suicide attempts: two populations or one? Psychol Med 31:837–845
Baca-Garcia E, Perez-Rodriguez MM, Sastre CD et al (2005) Suicidal behavior in schizophrenia and depression: a comparison. Schizophr Res 75:77–81
Fedyszyn IE, Robinson J, Harris MG et al (2014) Suicidal behaviours during treatment for first-episode psychosis: towards a comprehensive approach to service-based prevention. Early Interv Psychiatry 8:387–395. https://doi.org/10.1111/eip.12084
Klonsky D, Kotov R, Bakst S et al (2012) Hopelessness as a predictor of attempted suicide among first admission patients with psychosis: a 10-year cohort study. Suicide Life Threat Behav 42:1–10
Villa J, Ehret BC, Depp CA (2020) Systematic review of the inclusion of psychosis in suicide-specific clinical trials. Crisis 41:233–236
Anderson KK, Norman R, MacDougall A et al (2018) Effectiveness of early psychosis intervention: comparison of service users and nonusers in population-based health administrative data. AJP 175:443–452. https://doi.org/10.1176/appi.ajp.2017.17050480
Nosek BA, Ebersole CR, DeHaven AC, Mellor DT (2018) The preregistration revolution. Proc Natl Acad Sci USA 115:2600–2606. https://doi.org/10.1073/pnas.1708274114
Bertelsen M, Jeppesen P, Petersen L et al (2007) Suicidal behaviour and mortality in first-episode psychosis: the OPUS trial. Br J Psychiatry 191:s140–s146. https://doi.org/10.1192/bjp.191.51.s140
Chan SKW, Chan SWY, Pang HH et al (2018) Association of an early intervention service for psychosis with suicide rate among patients with first-episode schizophrenia-spectrum disorders. JAMA Psychiat 75:458–464. https://doi.org/10.1001/jamapsychiatry.2018.0185
Power PJR, Bell RJ, Mills R et al (2003) Suicide prevention in first episode psychosis: the development of a randomised controlled trial of cognitive therapy for acutely suicidal patients with early psychosis. Aust N Z J Psychiatry 37:414–420
Tarrier N, Kelly J, Maqsood S et al (2014) The cognitive behavioural prevention of suicide in psychosis: a clinical trial. Schizophr Res 156:204–210. https://doi.org/10.1016/j.schres.2014.04.029
Haddock G, Pratt D, Gooding PA et al (2019) Feasibility and acceptability of suicide prevention therapy on acute psychiatric wards: randomised controlled trial. BJPsych Open 5:e14. https://doi.org/10.1192/bjo.2018.85
Ellis TE, Newman CF (1996) Choosing to live: How to defeat suicide through cognitive therapy. New Harbinger Publications, Inc., Oakland
Freeman A, Reinecke MA (1993) Cognitive therapy of suicidal behavior: A manual for treatment. Springer, New York
Tarrier N, Gooding P, Pratt D et al (2013) Cognitive behavioural prevention of suicide in psychosis: A treatment manual. Routledge, New York
Bornheimer LA, Verdugo JL, Krasnick J et al (2023) A cognitive-behavioral suicide prevention treatment for adults with schizophrenia spectrum disorders in community mental health: preliminary findings of an open pilot study. Social Work Mental Health 311:114505. https://doi.org/10.1080/15332985.2023.2186736
Depp CA, Parrish EM, Chalker SA et al (2023) Pilot feasibility trial of a brief mobile-augmented suicide prevention intervention for serious mental illness. Psychiatr Rehabil J 46:74–82. https://doi.org/10.1037/prj0000547
Stanley B, Brown G, Brent DA et al (2010) Cognitive-behavioral therapy for suicide prevention (CBT-SP): treatment model, feasibility, and acceptability. J Am Acad Child Adolesc Psychiatry 48:1005–1013
Bryan CJ, Rozek DC (2018) Suicide prevention in the military: a mechanistic perspective. Curr Opin Psychol 22:27–32. https://doi.org/10.1016/j.copsyc.2017.07.022
Linehan MM (2014) DBT skills training manual: Second Edition. Guilford, New York
Morrison AP (2017) A manualised treatment protocol to guide delivery of evidence-based cognitive therapy for people with distressing psychosis: learning from clinical trials. Psychosis 9:271–281
Garety PA, Kuipers E, Fowler D et al (2001) A cognitive model of the positive symptoms of psychosis. Psychol Med 31:189–195
Freeman D, Garety PA, Kuipers E et al (2002) A cognitive model of persecutory delusions. Br J Clin Psychol 41:331–347
Beck AT, Rector NA, Stolar N, Grant P (2008) Schizophrenia: Cognitive theory, research, and therapy. Guilford Press
Freeman D, Garety PA (2003) Connecting neurosis and psychosis: the direct influence of emotion on delusions and hallucinations. Behav Res Ther 41:923–947
Sanchez-Gistau V, Baeza I, Arango C et al (2015) The affective dimension of early-onset psychosis and its relationship with suicide. J Child Psychol Psychiatry 56:747–755. https://doi.org/10.1111/jcpp.12332
Livingstone K, Harper S, Gillanders D (2009) An exploration of emotion regulation in psychosis. Clin Psychol Psychother 16:418–430. https://doi.org/10.1002/cpp.635
Birchwood M, Iqbal Z, Chadwick P, Trower P (2000) Cognitive approach to depression and suicidal thinking in psychosis. 1. Ontogeny of post-psychotic depression. Br J Psychiatry 177:516–521
Strauss GP, Esfahlani FZ, Visser KF et al (2019) Mathematically modeling emotion regulation abnormalities during psychotic experiences in schizophrenia. Clin Psychol Sci 7:216–233
Norman RMG, Malla AK (1991) Dysphoric mood and symptomatology in schizophrenia. Psychol Med 21:897–903. https://doi.org/10.1017/S0033291700029883
Kimhy D, Wall MM, Hansen MC et al (2017) Autonomic regulation and auditory hallucinations in individuals with schizophrenia: an experience sampling study. Schizophr Bull 43:754–763. https://doi.org/10.1093/schbul/sbw219
Myin-Germeys I, Delespaul PA, DeVries MW (2000) Schizophrenia patients are more emotionally active than is assumed based on their behavior. Schizophr Bull 26:847–854
O’Driscoll C, Laing J, Mason O (2014) Cognitive emotion regulation strategies, alexithymia and dissociation in schizophrenia, a review and meta-analysis. Clin Psychol Rev 34:482–495. https://doi.org/10.1016/j.cpr.2014.07.002
Kimhy D, Vakhrusheva J, Jobson-Ahmed L et al (2012) Emotion awareness and regulation in individuals with schizophrenia: Implications for social functioning. Psychiatry Res 200:193–201
Bridges JF, Slawik L, Schmeding A et al (2013) A test of concordance between patient and psychiatrist valuations of multiple treatment goals for schizophrenia. Health Expect 16:164–176
Hawton K, Sutton L, Haw C et al (2005) Schizophrenia and suicide: systematic review of risk factors. Br J Psychiatry 187:9–20
Challis S, Nielssen O, Harris A, Large M (2013) Systematic meta-analysis of the risk factors for deliberate self-harm before and after treatment for first-episode psychosis. Acta Psychiatr Scand 127:442–454. https://doi.org/10.1111/acps.12074
Barrett EA, Sundet K, Faerden A et al (2010) Suicidality before and in the early phases of first episode psychosis. Schizophr Res 119:11–17. https://doi.org/10.1016/j.schres.2010.03.022
Bornheimer LA (2018) Suicidal ideation in first-episode psychosis (FEP): examination of symptoms of depression and psychosis among individuals in an early phase of treatment. Suicide Life Threat Behav. https://doi.org/10.1111/sltb.12440
Upthegrove R, Birchwood M, Ross K et al (2009) The evolution of depression and suicidality in first episode psychosis: depression in first episode psychosis. Acta Psychiatr Scand 122:211–218. https://doi.org/10.1111/j.1600-0447.2009.01506.x
Robinson J, Harris MG, Harrigan SM et al (2010) Suicide attempt in first-episode psychosis: a 7.4 year follow-up study. Schizophr Res 116:1–8. https://doi.org/10.1016/j.schres.2009.10.009
Sanchez-Gistau V, Baeza I, Arango C et al (2013) Predictors of suicide attempt in early-onset, first-episode psychoses: a longitudinal 24-month follow-up study. J Clin Psychiatry 74:59–66. https://doi.org/10.4088/JCP.12m07632
Tarrier N, Haddock G, Lewis S et al (2006) Suicide behaviour over 18 months in recent onset schizophrenic patients: the effects of CBT. Schizophr Res 83:15–27
McGinty J, Sayeed Haque M, Upthegrove R (2018) Depression during first episode psychosis and subsequent suicide risk: a systematic review and meta-analysis of longitudinal studies. Schizophr Res 195:58–66. https://doi.org/10.1016/j.schres.2017.09.040
Fedyszyn IE, Harris MG, Robinson J et al (2011) Characteristics of suicide attempts in young people undergoing treatment for first episode psychosis. Aust N Z J Psychiatry 45:838–845. https://doi.org/10.3109/00048674.2011.595687
Tarrier N, Khan S, Cater J, Picken A (2007) The subjective consequences of suffering a first episode psychosis: trauma and suicide behaviour. Soc Psychiatry Psychiatr Epidemiol 42:29–35
Thompson RA (1994) Emotion regulation: a theme in search of definition. Monogr Soc Res Child Dev 59:25–52. https://doi.org/10.2307/1166137
Gross JJ (2008) Emotion regulation. Handbook of emotions, 3rd edn. Guilford Press, New York, pp 497–512
Khoury B, Lecomte T (2012) Emotion regulation and schizophrenia. Int J Cogn Ther 5:67–76
Tully LM, Niendam TA (2014) Beyond “cold” cognition: exploring cognitive control of emotion as a risk factor for psychosis. Curr Behav Neurosci Rep 1:170–181
Ludwig L, Werner D, Lincoln TM (2019) The relevance of cognitive emotion regulation to psychotic symptoms – a systematic review and meta-analysis. Clin Psychol Rev 72:101746. https://doi.org/10.1016/j.cpr.2019.101746
Kimhy D, Lister A, Liu Y et al (2020) The impact of emotion awareness and regulation on psychotic symptoms during daily functioning. NPJ Schizophr 6:1–7. https://doi.org/10.1038/s41537-020-0096-6
Pinkham AE, Penn DL, Perkins DO et al (2007) Emotion perception and social skill over the course of psychosis: a comparison of individuals “at-risk” for psychosis and individuals with early and chronic schizophrenia spectrum illness. Cogn Neuropsychiatry 12:198–212
Tremeau F (2006) A review of emotion deficits in schizophrenia. Dialogues Clin Neurosci 8:59–70
Kring AM, Caponigro JM (2010) Emotion in schizophrenia: where feeling meets thinking. Curr Dir Psychol Sci 19:255–259
Henry JD, Green MJ, de Lucia A et al (2007) Emotion dysregulation in schizophrenia: reduced amplification of emotional expression is associated with emotional blunting. Schizophr Res 95:197–204
Mandal MK, Pandey R, Prasad AB (1998) Facial expressions of emotions and schizophrenia: a review. Schizophr Bull 24:399–412
Lincoln TM, Hartmann M, Köther U, Moritz S (2015) Do people with psychosis have specific difficulties regulating emotions? Clin Psychol Psychother 22:637–646
Horan WP, Hajcak G, Wynn JK, Green MF (2013) Impaired emotion regulation in schizophrenia: evidence from event-related potentials. Psychol Med 43:2377–2391
Visser KF, Esfahlani FZ, Sayama H, Strauss GP (2018) An ecological momentary assessment evaluation of emotion regulation abnormalities in schizophrenia. Psychol Med 48:2337–2345
Myin-Germeys I, Peeters F, Havermans R et al (2003) Emotional reactivity to daily life stress in psychosis and affective disorder: an experience sampling study. Acta Psychiatr Scand 107:124–131. https://doi.org/10.1034/j.1600-0447.2003.02025.x
Bonfils KA, Lysaker PH (2020) Levels of distress tolerance in schizophrenia appear equivalent to those found in borderline personality disorder. J Clin Psychol 76:1668–1676. https://doi.org/10.1002/jclp.22944
Cohen AS, Minor KS (2008) Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies. Schizophr Bull 36:143–150
Vakhrusheva J, Khan S, Chang R et al (2020) Lexical analysis of emotional responses to “real-world” experiences in individuals with schizophrenia. Schizophr Res 216:272–278. https://doi.org/10.1016/j.schres.2019.11.045
Grattan R, Tully L, Lesh T et al (2019) F64. Exploring the role of emotion dysregulation and impulsivity on suicidal ideation and behavior within an early psychosis population. Schizophr Bull 45:S279–S279
Palmier-Claus J, Shryane N, Taylor P et al (2013) Mood variability predicts the course of suicidal ideation in individuals with first and second episode psychosis. Psychiatry Res 206:240–245. https://doi.org/10.1016/j.psychres.2012.11.014
Palmier-Claus J, Taylor PJ, Gooding P et al (2012) Affective variability predicts suicidal ideation in individuals at ultra-high risk of developing psychosis: an experience sampling study. Br J Clin Psychol 51:72–83. https://doi.org/10.1111/j.2044-8260.2011.02013.x
Mork E, Mehlum L, Barrett EA et al (2012) Self-harm in patients with schizophrenia spectrum disorders. Arch Suicide Res 16:111–123. https://doi.org/10.1080/13811118.2012.667328
DeVylder JE, Hilimire MR (2015) Suicide risk, stress sensitivity, and self-esteem among young adults reporting auditory hallucinations. Health Soc Work 40:175–181
Palmier-Claus J, Ainsworth J, Machin M et al (2013) Affective instability prior to and after thoughts about self-injury in individuals with and at-risk of psychosis: a mobile phone based study. Arch Suicide Res 17:275–287. https://doi.org/10.1080/13811118.2013.805647
Tarrier N, Gooding P, Gregg L et al (2007) Suicide schema in schizophrenia: the effect of emotional reactivity, negative symptoms and schema elaboration. Behav Res Ther 45:2090–2097. https://doi.org/10.1016/j.brat.2007.03.007
Bellack AS, Mueser KT, Gingerich S, Agresta J (2004) Social skills training for schizophrenia: a step-by-step guide, 2nd edn. Guilford Press, New York
Barlati S, Deste G, De Peri L et al (2013) Cognitive remediation in schizophrenia: current status and future perspectives. Schizophr Res Treatment. https://doi.org/10.1155/2013/156084
Thase ME, Kingdon D, Turkington D (2014) The promise of cognitive behavior therapy for treatment of severe mental disorders: a review of recent developments. World Psychiatry 13:244–250. https://doi.org/10.1002/wps.20149
Kane JM, Robinson DG, Schooler NR et al (2016) Comprehensive versus usual community care for first-episode psychosis: 2-year outcomes from the NIMH RAISE Early Treatment Program. AJP 173:362–372. https://doi.org/10.1176/appi.ajp.2015.15050632
Marino L, Nossel I, Choi JC et al (2015) The RAISE connection program for early psychosis: secondary outcomes and mediators and moderators of improvement. J Nerv Ment Dis 203:365–371. https://doi.org/10.1097/NMD.0000000000000293
Meltzer HY, Alphs L, Green AI et al (2003) Clozapine treatment for suicidality in SchizophreniaInternational Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry 60:82. https://doi.org/10.1001/archpsyc.60.1.82
Laws KR, Darlington N, Kondel TK et al (2018) Cognitive behavioural therapy for schizophrenia - outcomes for functioning, distress and quality of life: a meta-analysis. BMC Psychol 6:32. https://doi.org/10.1186/s40359-018-0243-2
Bateman K, Hansen L, Turkington D, Kingdon D (2007) Cognitive behavioral therapy reduces suicidal ideation in schizophrenia: results from a randomized controlled trial. Suicide Life Threat Behav 37:284–290
Khoury B, Lecomte T, Comtois G, Nicole L (2015) Third-wave strategies for emotion regulation in early psychosis: a pilot study. Early Interv Psychiatry 9:76–83. https://doi.org/10.1111/eip.12095
Lawlor C, Vitoratou S, Duffy J et al (2022) Managing emotions in psychosis: evaluation of a brief DBT-informed skills group for individuals with psychosis in routine community services. Br J Clin Psychol 61:735–756. https://doi.org/10.1111/bjc.12359
Ryan A, Crehan E, Khondoker M et al (2021) An emotional regulation approach to psychosis recovery: The Living Through Psychosis group programme. J Behav Therapy Exp Psychiatry 72:101651. https://doi.org/10.1016/j.jbtep.2021.101651
Ritschel LA, Lim NE, Stewart LM (2015) Transdiagnostic applications of DBT for adolescents and adults. Am J Psychother 69:111–128
Neacsiu AD, Eberle JW, Kramer R et al (2014) Dialectical behavior therapy skills for transdiagnostic emotion dysregulation: a pilot randomized controlled trial. Behav Res Ther 59:40–51
Slee N, Spinhoven P, Garnefski N, Arensman E (2008) Emotion regulation as mediator of treatment outcome in therapy for deliberate self-harm. Clin Psychol Psychother 15:205–216. https://doi.org/10.1002/cpp.577
DeCou CR, Comtois KA, Landes SJ (2019) Dialectical behavior therapy is effective for the treatment of suicidal behavior: a meta-analysis. Behav Ther 50:60–72
Hill DM, Craighead LW, Safer DL (2011) Appetite-focused dialectical behavior therapy for the treatment of binge eating with purging: a preliminary trial. Int J Eat Disord 44:249–261
Rizvi SL, Steffel LM (2014) A pilot study of 2 brief forms of dialectical behavior therapy skills training for emotion dysregulation in college students. J Am Coll Health 62:434–439. https://doi.org/10.1080/07448481.2014.907298
Muhomba M, Chugani CD, Uliaszek AA, Kannan D (2017) Distress tolerance skills for college students: a pilot investigation of a brief DBT group skills training program. J Coll Stud Psychother 31:247–256
Linehan MM, Shearin EN (1988) Lethal stress: a social-behavioral model of suicidal behavior. In: Coombs M, Fisher S (eds) Handbook of life stress, cognition and health. Wiley, Chichester, pp 265–285
Neacsiu AD, Bohus M, Linehan MM (2014) Dialectical behavior therapy: an intervention for emotion dysregulation. Handbook of emotion regulation. Guilford Press, New York, pp 491–507
Valentine SE, Bankoff SM, Poulin RM et al (2015) The use of dialectical behavior therapy skills training as stand-alone treatment: a systematic review of the treatment outcome literature. J Clin Psychol 71:1–20
Goodman M, Banthin D, Blair N et al (2016) A randomized trial of dialectical behavior therapy in high-risk suicidal veterans. J Clin Psychiatry 77:e1591–e1600. https://doi.org/10.4088/JCP.15m10235
Phalen P, Grossmann J, Bruder T et al (2022) Description of a dialectical behavior therapy program in a veterans affairs health care system. Eval Program Plan 92:102098. https://doi.org/10.1016/j.evalprogplan.2022.102098
Jablensky A, McGrath J, Herrman H et al (2000) Psychotic disorders in urban areas: an overview of the study on low prevalence disorders. Aust N Z J Psychiatry 34:221–236. https://doi.org/10.1080/j.1440-1614.2000.00728.x
Linehan MM, Laffaw JA (1982) Suicidal behaviors among clients at an outpatient psychology clinic versus the general population. Suicide Life Threat Behav 12:234–239. https://doi.org/10.1111/j.1943-278X.1982.tb00711.x
Bora E, Murray RM (2013) Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis? Schizophr Bull 40:744–755
Bora E, Yücel M, Pantelis C (2009) Cognitive functioning in schizophrenia, schizoaffective disorder and affective psychoses: meta-analytic study. Br J Psychiatry 195:475–482
Seidman LJ, Cherkerzian S, Goldstein JM et al (2013) Neuropsychological performance and family history in children at age 7 who develop adult schizophrenia or bipolar psychosis in the New England Family Studies. Psychol Med 43:119–131
Lyne J, O’Donoghue B, Owens E et al (2012) Prevalence of item level negative symptoms in first episode psychosis diagnoses. Schizophr Res 135:128–133. https://doi.org/10.1016/j.schres.2012.01.004
Sauvé G, Brodeur MB, Shah JL, Lepage M (2019) The prevalence of negative symptoms across the stages of the psychosis continuum. Harv Rev Psychiatry 27:15–32. https://doi.org/10.1097/HRP.0000000000000184
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DJ receives royalties from American Psychological Association Press and Guilford Press; he is also co-owner of CAMS-care, LLC (a professional training and consultation company). The authors report no relationships with commercial interests.
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Phalen, P., Kimhy, D., Jobes, D. et al. Emotional distress and dysregulation as treatment targets to reduce suicide in psychosis: a scoping review. Eur Arch Psychiatry Clin Neurosci (2023). https://doi.org/10.1007/s00406-023-01675-x
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DOI: https://doi.org/10.1007/s00406-023-01675-x