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Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea

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European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

Insomnia disorder (ID) and obstructive sleep apnea (OSA) are the two most prevalent sleep disorders worldwide, but the pathological mechanism has not been fully understood. Functional neuroimaging findings indicated regional abnormal neural activities existed in both diseases, but the results were inconsistent. This meta-analysis aimed to explore concordant regional functional brain changes in ID and OSA, respectively. We conducted a coordinate-based meta-analysis (CBMA) of resting-state functional magnetic resonance imaging (rs-fMRI) studies using the anisotropic effect-size seed‐based d mapping (AES-SDM) approach. Studies that applied regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF) or fractional ALFF (fALFF) to analyze regional spontaneous brain activities in ID or OSA were included. Meta-regressions were then applied to investigate potential associations between demographic variables and regional neural activity alterations. Significantly increased brain activities in the left superior temporal gyrus (STG.L) and right superior longitudinal fasciculus (SLF.R), as well as decreased brain activities in several right cerebral hemisphere areas were identified in ID patients. As for OSA patients, more distinct and complicated functional activation alterations were identified. Several neuroimaging alterations were functionally correlated with mean age, duration or illness severity in two patients groups revealed by meta-regressions. These functionally altered areas could be served as potential targets for non-invasive brain stimulation methods. This present meta-analysis distinguished distinct brain function changes in ID and OSA, improving our knowledge of the neuropathological mechanism of these two most common sleep disturbances, and also provided potential orientations for future clinical applications.

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Acknowledgements

This study was supported by the Key Research and Development Plan of Jining City (2021YXNS024), the Medical and Health Science and Technology Development Plan of Shandong Province (202003061210), the Cultivation Plan of High-level Scientific Research Projects of Jining Medical University (JYGC2021KJ006), the National Natural Science Foundation of China (81901358), the Natural Science Foundation of Shandong Province (ZR2019BH001 and ZR2021YQ55), the Young Taishan Scholars of Shandong Province (tsqn201909146), and the Supporting Fund for Teachers’ Research of Jining Medical University (600903001).

Funding

Key Research and Development Plan of Jining City, 2021YXNS024, Cong Zhou, Medical and Health Science and Technology Development Plan of Shandong Province, 202003061210, Cong Zhou, Cultivation Plan of High-level Scientific Research Projects of Jining Medical University, JYGC2021KJ006, Cong Zhou, National Natural Science Foundation of China, 81901358, Hao Yu, Natural Science Foundation of Shandong Province, ZR2019BH001, Hao Yu,ZR2021YQ55, Hao Yu, Taishan Scholar Foundation of Shandong Province, tsqn201909146, Hao Yu, Supporting Fund for Teachers’ Research of Jining Medical University, 600903001, Cong Zhou

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Authors and Affiliations

  1. School of Mental Health, Jining Medical University, Jining, China

    Weiwei Duan, Hao Yu, Man Dong, Fangfang Xu, Na Li, Ying Li, Yinghong Xu, Zhe Ji & Cong Zhou

  2. Department of Sleep Medicine, Shandong Daizhuang Hospital, Jining, China

    Xia Liu

  3. Department of Psychiatry, Xiamen Xianyue Hospital, Xiamen, China

    Liangliang Ping

  4. Department of Psychology, Affiliated Hospital of Jining Medical University, Jining, China

    Shushu Jin & Cong Zhou

  5. Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, China

    Yuqi Cheng & Xiufeng Xu

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Duan, W., Liu, X., Ping, L. et al. Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea. Eur Arch Psychiatry Clin Neurosci 273, 493–509 (2023). https://doi.org/10.1007/s00406-022-01485-7

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