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Alterations in resting-state gamma activity in patients with schizophrenia: a high-density EEG study

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Abstract

Alterations of EEG gamma activity in schizophrenia have been reported during sensory and cognitive tasks, but it remains unclear whether changes are present in resting state. Our aim was to examine whether changes occur in resting state, and to delineate those brain regions where gamma activity is altered. Furthermore, we wanted to identify the associations between changes in gamma activity and psychopathological characteristics. We studied gamma activity (30–48 Hz) in 60 patients with schizophrenia and 76 healthy controls. EEGs were acquired in resting state with closed eyes using a high-density, 256-channel EEG-system. The two groups were compared in absolute power measures in the gamma frequency range. Compared to controls, in patients with schizophrenia the absolute power was significantly elevated (false discovery rate corrected p < 0.05). The alterations clustered into fronto-central and posterior brain regions, and were positively associated with the severity of psychopathology, measured by the PANSS. Changes in gamma activity can lead to disturbed coordination of large-scale brain networks. Thus, the increased gamma activity in certain brain regions that we found may result in disturbances in temporal coordination of task-free/resting-state networks in schizophrenia. Positive association of increased gamma power with psychopathology suggests that altered gamma activity provides a contribution to symptom presentation.

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Funding

This study was supported by the Hungarian National Brain Research Program (KTIA_NAP_13-1-2013-0001).

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, Semmelweis University, Balassa street 6, 1083, Budapest, Hungary

    Máté Baradits, Brigitta Kakuszi, Sára Bálint, Máté Fullajtár, István Bitter & Pál Czobor

  2. Department of Psychiatry, Szent Borbála Hospital, Tatabánya, Hungary

    László Mód

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  1. Máté Baradits
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Correspondence to Máté Baradits.

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Baradits, M., Kakuszi, B., Bálint, S. et al. Alterations in resting-state gamma activity in patients with schizophrenia: a high-density EEG study. Eur Arch Psychiatry Clin Neurosci 269, 429–437 (2019). https://doi.org/10.1007/s00406-018-0889-z

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