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Pediatric chronic rhinosinusitis

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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

An up-to-date overview of diagnosis, differential diagnosis, comorbidities, and current medical and surgical management of pediatric chronic rhinosinusitis (PCRS).

Methods

Review of current evidence-based literature on PCRS.

Results

Diagnosis of PCRS seems to be improving based on recent evidence using nasal endoscopy as well as computed tomography scanning. Recent literature supports the fact that chronic adenoiditis can be an independent etiology of symptoms of chronic sinusitis, that are very similar to chronic adenoiditis. Allergic rhinitis and immune deficiency play important roles in the management of PCRS. Surgery for PCRS has evolved significantly in the last 15–20 years to include adenoidectomy as well as endoscopic sinus surgery.

Conclusions

PCRS is very common in children causing poor QOL for these children. Medical management remains the main stay of treatment with attention to management of co-morbidities that may contribute to the disease severity. Making the correct diagnosis will help with the choice of surgical intervention if medical management fails.

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Data availability

Not applicable.

References

  1. Snidvongs K, Sangubol M, Poachanukoon O (2020) Pediatric versus adult chronic rhinosinusitis. Curr Allergy Asthma Rep 20:29. https://doi.org/10.1007/s11882-020-00924-6

    Article  PubMed  Google Scholar 

  2. Jaume F, Valls-Mateus M, Mullol J (2020) Common cold and acute rhinosinusitis: up-to-date management in 2020. Curr Allergy Asthma Rep 20:28. https://doi.org/10.1007/s11882-020-00917-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Gilani S, Shin JJ (2017) The burden and visit prevalence of pediatric chronic rhinosinusitis. Otolaryngol Head Neck Surg 157:1048–1052. https://doi.org/10.1177/0194599817721177

    Article  PubMed  Google Scholar 

  4. Ramadan HH, Chaiban R, Makary C (2022) Pediatric rhinosinusitis. Pediatr Clin North Am 69:275–286. https://doi.org/10.1016/j.pcl.2022.01.002

    Article  PubMed  Google Scholar 

  5. Fokkens WJ, Lund VJ, Hopkins C et al (2020) European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 58:1–464. https://doi.org/10.4193/Rhin20.600

    Article  PubMed  Google Scholar 

  6. Orlandi RR, Kingdom TT, Smith TL et al (2021) International consensus statement on allergy and rhinology: rhinosinusitis 2021. Int Forum Allergy Rhinol 11:213–739. https://doi.org/10.1002/alr.22741

    Article  PubMed  Google Scholar 

  7. Purnell PR, Ramadan JH, Ramadan HH (2019) Can symptoms differentiate between chronic adenoiditis and chronic rhinosinusitis in pediatric patients. Ear Nose Throat J 98:279–282. https://doi.org/10.1177/0145561319840133

    Article  PubMed  Google Scholar 

  8. Brietzke SE, Shin JJ, Choi S et al (2014) Clinical consensus statement: pediatric chronic rhinosinusitis. Otolaryngol Head Neck Surg 151:542–553. https://doi.org/10.1177/0194599814549302

    Article  PubMed  Google Scholar 

  9. Leo G, Incorvaia C, Masieri S, Triulzi F (2010) Imaging criteria for diagnosis of chronic rhinosinusitis in children. Eur Ann Allergy Clin Immunol 42:199–204

    CAS  PubMed  Google Scholar 

  10. Lund VJ, Kennedy DW (1995) Quantification for staging sinusitis. The staging and therapy group. Ann Otol Rhinol Laryngol Suppl 167:17–21. https://doi.org/10.1177/000348949510410s02

    Article  CAS  PubMed  Google Scholar 

  11. Bhattacharyya N, Jones DT, Hill M, Shapiro NL (2004) The diagnostic accuracy of computed tomography in pediatric chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 130:1029–1032. https://doi.org/10.1001/archotol.130.9.1029

    Article  PubMed  Google Scholar 

  12. Terrell AM, Ramadan HH (2009) Correlation between SN-5 and computed tomography in children with chronic rhinosinusitis. Laryngoscope 119:1394–1398. https://doi.org/10.1002/lary.20250

    Article  PubMed  Google Scholar 

  13. Orabi NA, Makary CA, Ramadan HH (2022) The use of SN-5 to differentiate chronic rhinosinusitis and chronic adenoiditis in children. Int J Pediatr Otorhinolaryngol 161:111269. https://doi.org/10.1016/j.ijporl.2022.111269

    Article  PubMed  Google Scholar 

  14. Sedaghat AR, Phipatanakul W, Cunningham MJ (2014) Prevalence of and associations with allergic rhinitis in children with chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol 78:343–347. https://doi.org/10.1016/j.ijporl.2013.12.006

    Article  PubMed  Google Scholar 

  15. Orb Q, Curtin K, Oakley GM et al (2016) Familial risk of pediatric chronic rhinosinusitis. Laryngoscope 126:739–745. https://doi.org/10.1002/lary.25469

    Article  PubMed  Google Scholar 

  16. Babinski D, Trawinska-Bartnicka M (2008) Rhinosinusitis in cystic fibrosis: not a simple story. Int J Pediatr Otorhinolaryngol 72:619–624. https://doi.org/10.1016/j.ijporl.2008.01.010

    Article  PubMed  Google Scholar 

  17. Krajewska J, Zub K, Słowikowski A, Zatoński T (2022) Chronic rhinosinusitis in cystic fibrosis: a review of therapeutic options. Eur Arch Otorhinolaryngol 279:1–24. https://doi.org/10.1007/s00405-021-06875-6

    Article  PubMed  Google Scholar 

  18. Baroody FM (2007) Mucociliary transport in chronic rhinosinusitis. Clin Allergy Immunol 20:103–119

    PubMed  Google Scholar 

  19. Suzaki I, Hirano K, Arai S et al (2020) Primary ciliary dyskinesia with refractory chronic rhinosinusitis. Am J Case Rep 21:e923270. https://doi.org/10.12659/AJCR.923270

    Article  PubMed  PubMed Central  Google Scholar 

  20. Mazza JM, Lin SY (2016) Primary immunodeficiency and recalcitrant chronic sinusitis: a systematic review. Int Forum Allergy Rhinol 6:1029–1033. https://doi.org/10.1002/alr.21789

    Article  PubMed  Google Scholar 

  21. Hanna BC, Wormald PJ (2012) Gastroesophageal reflux and chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 20:15–18. https://doi.org/10.1097/MOO.0b013e32834e8f11

    Article  PubMed  Google Scholar 

  22. Rosati MG, Peters AT (2016) Relationships among allergic rhinitis, asthma, and chronic rhinosinusitis. Am J Rhinol Allergy 30:44–47. https://doi.org/10.2500/ajra.2016.30.4252

    Article  PubMed  PubMed Central  Google Scholar 

  23. Ryu G, Min C, Park B et al (2020) Bidirectional association between asthma and chronic rhinosinusitis: two longitudinal follow-up studies using a national sample cohort. Sci Rep 10:9589. https://doi.org/10.1038/s41598-020-66479-8

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  24. Keir J (2009) Why do we have paranasal sinuses? J Laryngol Otol 123:4–8. https://doi.org/10.1017/S0022215108003976

    Article  CAS  PubMed  Google Scholar 

  25. Slack CL, Dahn KA, Abzug MJ, Chan KH (2001) Antibiotic-resistant bacteria in pediatric chronic sinusitis. Pediatr Infect Dis J 20:247–250. https://doi.org/10.1097/00006454-200103000-00006

    Article  CAS  PubMed  Google Scholar 

  26. Belcher R, Virgin F (2019) The role of the adenoids in pediatric chronic rhinosinusitis. Med Sci 7:35. https://doi.org/10.3390/medsci7020035

    Article  Google Scholar 

  27. Cho SH, Hamilos DL, Han DH, Laidlaw TM (2020) Phenotypes of chronic rhinosinusitis. J Allergy Clin Immunol Pract 8:1505–1511. https://doi.org/10.1016/j.jaip.2019.12.021

    Article  PubMed  PubMed Central  Google Scholar 

  28. Heath J, Hartzell L, Putt C, Kennedy JL (2018) Chronic rhinosinusitis in children: pathophysiology, evaluation, and medical management. Curr Allergy Asthma Rep 18:37. https://doi.org/10.1007/s11882-018-0792-8

    Article  CAS  PubMed  Google Scholar 

  29. Brook I (2016) Microbiology of chronic rhinosinusitis. Eur J Clin Microbiol Infect Dis 35:1059–1068. https://doi.org/10.1007/s10096-016-2640-x

    Article  CAS  PubMed  Google Scholar 

  30. Tan KS, Yan Y, Ong HH et al (2017) Impact of respiratory virus infections in exacerbation of acute and chronic rhinosinusitis. Curr Allergy Asthma Rep 17:24. https://doi.org/10.1007/s11882-017-0693-2

    Article  PubMed  PubMed Central  Google Scholar 

  31. Pawankar R, Nonaka M (2007) Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps. Curr Allergy Asthma Rep 7:202–208. https://doi.org/10.1007/s11882-007-0073-4

    Article  CAS  PubMed  Google Scholar 

  32. Veskitkul J, Vichyanond P, Pacharn P, Visitsunthorn N, Jirapongsananuruk O (2015) Clinical characteristics of recurrent acute rhinosinusitis in children. Asian Pac J Allergy Immunol 33:276–280. https://doi.org/10.12932/AP0591.33.4.2015

    Article  CAS  PubMed  Google Scholar 

  33. Kuruvilla M, de la Morena MT (2013) Antibiotic prophylaxis in primary immune deficiency disorders. J Allergy Clin Immunol Pract 1:573–582. https://doi.org/10.1016/j.jaip.2013.09.013

    Article  PubMed  Google Scholar 

  34. Hansen FS, Hoffmans R, Georgalas C, Fokkens WJ (2012) Complications of acute rhinosinusitis in The Netherlands. Fam Pract 29:147–153. https://doi.org/10.1093/fampra/cmr062

    Article  CAS  PubMed  Google Scholar 

  35. Barshak MB, Durand ML (2017) The role of infection and antibiotics in chronic rhinosinusitis. Laryngoscope Investig Otolaryngol 2:36–42. https://doi.org/10.1002/lio2.61

    Article  PubMed  PubMed Central  Google Scholar 

  36. Varshney R, Lee JT (2017) Current trends in topical therapies for chronic rhinosinusitis: update and literature review. Expert Opin Drug Deliv 14:257–271. https://doi.org/10.1080/17425247.2016.1214563

    Article  CAS  PubMed  Google Scholar 

  37. Jeffe JS, Bhushan B, Schroeder JW Jr (2012) Nasal saline irrigation in children: a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol 76:409–413. https://doi.org/10.1016/j.ijporl.2011.12.022

    Article  PubMed  Google Scholar 

  38. Ozturk F, Bakirtas A, Ileri F, Turktas I (2011) Efficacy and tolerability of systemic methylprednisolone in children and adolescents with chronic rhinosinusitis: a double-blind, placebo-controlled randomized trial. J Allergy Clin Immunol 128:348–352. https://doi.org/10.1016/j.jaci.2011.04.045

    Article  CAS  PubMed  Google Scholar 

  39. Chiarella SE, Grammer LC (2017) Immune deficiency in chronic rhinosinusitis: screening and treatment. Expert Rev Clin Immunol 13:117–123. https://doi.org/10.1080/1744666X.2016.1216790

    Article  CAS  PubMed  Google Scholar 

  40. Makary CA, Behnke J, Peppers B, Ramadan HH (2022) Outcome of immunoglobulin replacement therapy in adults with rhinosinusitis. Laryngoscope 132:732–736. https://doi.org/10.1002/lary.29694

    Article  CAS  PubMed  Google Scholar 

  41. Wucherpfennig L, Wuennemann F, Eichinger M et al (2023) Long-term effects of lumacaftor/ivacaftor on paranasal sinus abnormalities in children with cystic fibrosis detected with magnetic resonance imaging. Front Pharmacol 14:1161891. https://doi.org/10.3389/fphar.2023.1161891

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Yim MT, Smith KA, Alt JA, Orlandi RR (2021) The value of endoscopic sinus surgery in chronic rhinosinusitis. Laryngoscope Investig Otolaryngol 6:58–63. https://doi.org/10.1002/lio2.523

    Article  PubMed  PubMed Central  Google Scholar 

  43. Makary CA, Ramadan HH (2013) The role of sinus surgery in children. Laryngoscope 123:1348–1352. https://doi.org/10.1002/lary.23961

    Article  PubMed  Google Scholar 

  44. Vlastarakos PV, Fetta M, Segas JV et al (2013) Functional endoscopic sinus surgery improves sinus-related symptoms and quality of life in children with chronic rhinosinusitis: a systematic analysis and meta-analysis of published interventional studies. Clin Pediatr 52:1091–1097. https://doi.org/10.1177/0009922813506489

    Article  Google Scholar 

  45. Schupper AJ, Nation J, Pransky S (2018) Adenoidectomy in children: what is the evidence and what is its role? Curr Otorhinolaryngol Rep 6:64–73. https://doi.org/10.1007/s40136-018-0190-8

    Article  PubMed  PubMed Central  Google Scholar 

  46. Ramadan HH (2004) Surgical management of chronic sinusitis in children. Laryngoscope 114:2103–2109. https://doi.org/10.1097/01.mlg.0000149441.28231.0c

    Article  PubMed  Google Scholar 

  47. Ramadan HH, Makary CA (2014) Can computed tomography score predict outcome of adenoidectomy for chronic rhinosinusitis in children. Am J Rhinol Allergy 28:e80-82. https://doi.org/10.2500/ajra.2014.28.4004

    Article  PubMed  Google Scholar 

  48. Ramadan HH, Cost JL (2008) Outcome of adenoidectomy versus adenoidectomy with maxillary sinus wash for chronic rhinosinusitis in children. Laryngoscope 118:871–873. https://doi.org/10.1097/MLG.0b013e3181653422

    Article  PubMed  Google Scholar 

  49. Mirza AA, Shawli HY, Alandejani TA et al (2020) Efficacy and safety of paranasal sinus balloon catheter dilation in pediatric chronic rhinosinusitis: a systematic review. J Otolaryngol Head Neck Surg 49:69. https://doi.org/10.1186/s40463-020-00463-0

    Article  PubMed  PubMed Central  Google Scholar 

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Ramadan, H.H. Pediatric chronic rhinosinusitis. Eur Arch Otorhinolaryngol 281, 1131–1137 (2024). https://doi.org/10.1007/s00405-023-08307-z

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