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Sensibility, specificity, and accuracy of the Sinonasal Outcome Test 8 (SNOT-8) in patients with chronic rhinosinusitis (CRS): a cross-sectional cohort study

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To analyze as the primary endpoint the accuracy, sensitivity, and specificity of the SNOT-22 assessing CRS severity and to compare the results with a version of the SNOT-8 obtained from the nasal domain items.

Methods

Data were obtained from a prospective multicenter controlled study of dupilumab in adults with moderate–severe CRSwNP. EQUATOR and STROBE network guidelines were adopted. A multivariate logistic regression model was used to evaluate the accuracy of the model with the full (SNOT-22) and reduced (SNOT-8) item set to predict the severity outcome.

Results

SNOT-22 demonstrated an AUC of 0.885 (95% CI 0.825, − 0.945), and sensitivity and specificity of 91.49% (83.92–96.25%) and 69.23% (48.21–85.67%), respectively. Interestingly, after stepwise items elimination good outcomes were reported for SNOT-8, with an AUC of 0.818 (95% CI 0.744–0.892), achieving a sensitivity of 93.51% (85.49–97.86%) and specificity of 57.14% (40.96–72.28%).

Conclusion

Psychometric analyses support the accuracy, sensitivity, and specificity of the nasal domains of SNOT-22 to assess the impact on HRQoL in patients with CRSwNP.

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Data available on request due to privacy/ethical restrictions.

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Authors and Affiliations

  1. Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia” ENT Section, University of Catania, 95123, Catania, Italy

    Ignazio La Mantia, Martina Ragusa, Egle Grigaliute, Salvatore Cocuzza & Antonino Maniaci

  2. Study Group of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, 75000, France

    Thomas Radulesco, Christian Calvo-Henriquez, Alberto Maria Saibene, Jerome Rene Lechien, Nicolas Fakhry, Justin Michel & Antonino Maniaci

  3. Department of Oto-Rhino-Laryngology Head and Neck Surgery, Aix-Marseille University, APHM, IUSTI, La Conception University Hospital, Marseille, 13000, France

    Thomas Radulesco, Nicolas Fakhry, Justin Michel & Antonino Maniaci

  4. Otolaryngology Unit Santi Paolo e Carlo Hospital Department of Health Sciences, Università degli Studi di Milano, Milan, 20100, Italy

    Alberto Maria Saibene

  5. Department of Mathematics and Informatics, University of Catania, 95123, Catania, Italy

    Paolo Marco Riela

  6. Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), 4556, Mons, Belgium

    Jerome Rene Lechien

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  1. Ignazio La Mantia
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  2. Martina Ragusa
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  11. Justin Michel
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Correspondence to Antonino Maniaci.

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La Mantia, I., Ragusa, M., Grigaliute, E. et al. Sensibility, specificity, and accuracy of the Sinonasal Outcome Test 8 (SNOT-8) in patients with chronic rhinosinusitis (CRS): a cross-sectional cohort study. Eur Arch Otorhinolaryngol 280, 3259–3264 (2023). https://doi.org/10.1007/s00405-023-07855-8

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