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A population-based model identifying optimal candidate for primary tumor resection in distant metastatic laryngeal carcinoma

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To developed a model to screen distant metastatic laryngeal carcinoma (DMLC) patients who would benefit from the primary tumor resection.

Methods

The propensity score matching (PSM) was utilized to avoid disproportionate distributions of the confounding factors. We hypothesized that patients who underwent surgery would benefit from surgery by having a longer median cancer-specific survival (CSS) than patients without surgery. Multivariable Cox model was used to explore the independent factors of CSS and overall survival (OS) among PSM population. We used these factors to construct a nomogram to identify surgery benefit patients. The predictive performance and clinical practicability of the nomogram were determined by area under the curve (AUC), calibration curve, and decision curve.

Results

The CSS and OS for patients who received primary tumor resection were significantly longer than those without resection (median CSS: 19 months vs. 10 months, P = 0.009; median OS: 21 months vs. 10 months, P = 0.001). The nomogram displayed a good degree of discrimination and calibration. The mean AUC of the nomogram was 0.70 (95% confidence interval [CI] 0.66–0.76) through threefold cross-validation.

Conclusions

A predictive model was established and might be used to screen the optimal candidates for primary tumor surgery in DMLC patients.

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Data Availability

This study was based on the publicly available data from the Surveillance, Epidemiology, and End Results (SEER) program and available in the public domain: https://seer.cancer.gov/.

Abbreviations

LC:

Laryngeal carcinoma

DMLC:

Distant metastasis of laryngeal carcinoma

SCC:

Squamous cell carcinoma

SEER:

Surveillance, Epidemiology and End Results

AJCC:

American Joint Committee on Cancer

RT:

Radiation

CHT:

Chemotherapy

CRT:

Chemoradiotherapy

TAS:

Treatment after surgery

NCCN:

National Comprehensive Cancer Network

PSM:

Propensity score matching

CSS:

Cancer-specific survival

OS:

Overall survival

References

  1. Sung H, Ferlay J, Soerjomataram I et al (2020) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–449. https://doi.org/10.3322/caac.21660

    Article  Google Scholar 

  2. Cosetti M, Yu GP, Schantz SP (2008) Five-year survival rates and time trends of laryngeal cancer in the US population. Arch Otolaryngol Head Neck Surg 134(4):370–379. https://doi.org/10.1001/archotol.134.4.370

    Article  PubMed  Google Scholar 

  3. Liu JC, Bhayani M, Kuchta K, Galloway T, Fundakowski C (2019) Patterns of distant metastasis in head and neck cancer at presentation: implications for initial evaluation. Oral Oncol 88:131–136. https://doi.org/10.1016/j.oraloncology.2018.11.023

  4. Kowalski LP, Carvalho AL (2000) Natural history of untreated head and neck cancer. Eur J Cancer 36(8):1032–1037. https://doi.org/10.1016/s0959-8049(00)00054-x

    Article  CAS  PubMed  Google Scholar 

  5. NCCN clinical practice guidelines in oncology, Head and Neck Cancers, Version 2.2021. IOP Publishing Physics Web. http://www.nccn.org/patients. Accessed 26 Mar 2021

  6. Pan Y, Hong Y, Liang Z, Zhuang W et al (2019) Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database. Eur Arch Oto-rhino-laryngol Head Neck Surg 276(1):193–201. https://doi.org/10.1007/s00405-018-5244-5

    Article  Google Scholar 

  7. Lin Z, Lin H, C X, et al (2020) The primary tumor resection in patients with distant metastatic laryngeal carcinoma. Eur Arch Oto-rhino-laryngol Head Neck Surg 277(10):2859–2868. https://doi.org/10.1007/s00405-020-05987-9

    Article  Google Scholar 

  8. Feuer EJ, Lee M, Mariotto AB et al (2012) The Cancer Survival Query System: making survival estimates from the surveillance, epidemiology, and end results program more timely and relevant for recently diagnosed patients. Cancer 118(22):5652–5662. https://doi.org/10.1002/cncr.27615

    Article  PubMed  Google Scholar 

  9. Morgan CJ (2018) Reducing bias using propensity score matching. J Nucl Cardiol 25(2):404–406. https://doi.org/10.1007/s12350-017-1012-y

    Article  PubMed  Google Scholar 

  10. McCaffrey DF, Ridgeway G, Morral AR (2004) Propensity score estimation with boosted regression for evaluating causal effects in observational studies. Psychol Methods 9:403–425. https://doi.org/10.1037/1082-989X.9.4.403

    Article  PubMed  Google Scholar 

  11. Austin PC (2009) Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med 28:3083–3107. https://doi.org/10.1002/sim.3697

    Article  PubMed  PubMed Central  Google Scholar 

  12. Wiegand S, Zimmermann A, Wilhelm T, Werner JA (2015) Survival after distant metastasis in head and neck cancer. Anticancer Res 35(10):5499–5502

    PubMed  Google Scholar 

  13. Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF (2017) An update on larynx cancer. CA Cancer J Clin 67(1):31–50. https://doi.org/10.3322/caac.21386

    Article  PubMed  Google Scholar 

  14. Harrington KJ, Ferris RL, Blumenschein G Jr et al (2017) Nivolumab versus standard, single-agent therapy of investigator’s choice in recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141): health-related quality-of-life results from a randomised, phase3 trial. Lancet Oncol 18(8):1104–1115. https://doi.org/10.1016/S1470-2045(17)30421-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Demicheli R, Retsky MW, Hrushesky WJ, Baum M, Gukas ID (2008) The effects of surgery on tumor growth: A century of investigations. Ann Oncol 19:1821–1828. https://doi.org/10.1093/annonc/mdn386

    Article  CAS  PubMed  Google Scholar 

  16. Turner N, Tran B, Tran PV, Sinnathamby M, Wong HL, Jones I, Croxford M, Desai J, Tie J, Field KM, Kosmider S, Bae S, Gibbs P (2015) Primary tumor resection in patients with metastatic colorectal cancer is associated with reversal of systemic inflammation and improved survival. Clin Colorectal Cancer 14(3):185–191

    Article  PubMed  Google Scholar 

  17. Flanigan RC, Mickisch G, Sylvester R, Tangen C, Van Poppel H, Crawford ED (2004) Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol 171(3):1071–1076. https://doi.org/10.1097/01.ju.0000110610.61545.ae

    Article  PubMed  Google Scholar 

  18. Li H, Sun Z, Yang F et al (2019) Primary tumour resection in non-small-cell lung cancer patients with ipsilateral pleural dissemination (M1a): a population-based study. Eur J Cardiothorac Surg 55:1121–1129. https://doi.org/10.1093/ejcts/ezy439

    Article  PubMed  Google Scholar 

  19. Zhang R, Zou J, Li P, Li Q, Qiao Y, Han J, Huang K, Ruan P, Lin H, Song Q, Fu Z (2019) Surgery to the primary tumor is associated with improved survival of patients with metastatic esophageal cancer: propensity score-matched analyses of a large retrospective cohort. Dis Esophagus 33(3):doz051. https://doi.org/10.1093/dote/doz051

    Article  Google Scholar 

  20. Pan Y, Hong Y, Liang Z, Zhuang W (2019) Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database. Eur Arch Otorhinolaryngol 276(1):193–201. https://doi.org/10.1007/s00405-018-5244-5

    Article  PubMed  Google Scholar 

  21. Lin Z, Lin H, Chen X et al (2020) The primary tumor resection in patients with distant metastatic laryngeal carcinoma. Eur Arch Otorhinolaryngol 277(10):2859–2868. https://doi.org/10.1007/s00405-020-05987-9

    Article  PubMed  Google Scholar 

  22. Argiris A, Karamouzis MV, Raben D, Ferris RL (2008) Head and neck cancer. Lancet (London, England) 371(9625):1695–1709. https://doi.org/10.1016/S0140-6736(08)60728-X

    Article  CAS  PubMed  Google Scholar 

  23. Scherl C, Mantsopoulos K, Semrau S et al (2017) Management of advanced hypopharyngeal and laryngeal cancer with and without cartilage invasion. Auris Nasus Larynx 44:333–339. https://doi.org/10.1016/j.anl.2016.08.002

    Article  PubMed  Google Scholar 

  24. Yeh DH, Sahovaler A, Fung K (2017) Reconstruction after salvage laryngectomy. Oral Oncol 75:22–27. https://doi.org/10.1016/j.oraloncology.2017.10.009

    Article  PubMed  Google Scholar 

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Acknowledgements

This work is supported by the National Natural Science Fund of China (81671657). This work is founded by Tianjin Key Medical Discipline (Specialty) Construction Project and Tianjin Institute of imaging medicine.

Funding

This study has received funding by the National Natural Science Fund of China (81671657) and Tianjin Health Commission Science and Technology Key Project (Z20002). This work is founded by Tianjin Key Medical Discipline (Specialty) Construction Project and Tianjin Institute of imaging medicine.

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Author notes

  1. Wen Shen and Yining Yang contributed equally to this work as co-corresponding authors.

Authors and Affiliations

  1. Department of Radiology, Tianjin Medical Imaging Institute, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Nankai District, Tianjin, 300192, China

    Xiaobin Liu & Wen Shen

  2. Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Nankai District, Tianjin, 300192, China

    Peng Lin

  3. Department of Radiotherapy, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Nankai District, Tianjin, 300192, China

    Yining Yang

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Contributions

XL: design, acquisition of data, analysis, drafting, revision, PL: analysis and interpretation of data, revision, WS: analysis and interpretation of data, revision, YY: design, analysis and interpretation of data, revision, All authors: final approval of manuscript.

Corresponding author

Correspondence to Yining Yang.

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Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Informed consent

Written informed consent was not required for this study because the retrospective nature of the study.

Ethical approval

This study was based on the publicly available data from the Surveillance, Epidemiology, and End Results (SEER) program and available in the public domain: https://seer.cancer.gov/. Institutional Review Board approval was obtained from the medical ethics committee of the First Central Hospital of Tianjin.

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Liu, X., Lin, P., Shen, W. et al. A population-based model identifying optimal candidate for primary tumor resection in distant metastatic laryngeal carcinoma. Eur Arch Otorhinolaryngol 280, 2885–2896 (2023). https://doi.org/10.1007/s00405-023-07851-y

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  • DOI: https://doi.org/10.1007/s00405-023-07851-y

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