Abstract
Introduction
Seromucinous hamartoma (SH) is a rare benign glandular proliferation of the sinonasal tract and nasopharynx. Only few cases have been reported in recent years.
Materials and methods
We performed a retrospective medical record review of seven patients diagnosed with sinonasal SH who underwent endoscopic endonasal surgery.
Results
There were 5 males and 2 females, ranged in age from 40 to 98 years (mean 60 years, SD ± 18.9). Two lesions arise from middle turbinate, two from uncinate process, and 3 (but 4 specimens) from nasal septum. Pathological features revealed a polypoid lesion with submucosal proliferation of seromucinous glands arranged in lobular and haphazard patterns. In immunohistochemical study, the seromucinous glands of SH were reactive for cytokeratin, including CK7, CK19, HMWK, but negative for CK20.
Conclusion
Sinonasal SH is a rare diagnosis characterized by a polypoid lesion with a haphazard proliferation of seromucinous glands. The rhinologists should consider it in the differential diagnosis of a polypoid lesion in the nasal cavity.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board (IRB) of Taipei Veterans General Hospital (IRB No. 2016-05-001AC), and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Huang, YW., Kuo, YJ., Ho, CY. et al. Sinonasal seromucinous hamartoma. Eur Arch Otorhinolaryngol 275, 743–749 (2018). https://doi.org/10.1007/s00405-018-4885-8
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DOI: https://doi.org/10.1007/s00405-018-4885-8