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Method to test the long-term stability of functional electrical stimulation via multichannel electrodes (e.g., applicable for laryngeal pacing) and to define best points for stimulation: in vivo animal analysis

  • Laryngology
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Abstract

The study aim was to identify and analyze intramuscular electrically sensitive points. Electrically sensitive points are herein defined as positions, which allow muscles stimulation with a minimum possible fatigue for a maximum amount of time. A multichannel array electrode was used which could be interesting to retain the function of larynx muscle after paralysis. Eight array electrodes were implanted in the triceps brachii muscle of four rats. While being under anesthesia, the animals were intramuscularly stimulated at 16 different positions. Sihler’s staining technique was used to make visible the nerves routes and the intramuscular position of the individual electrode plate. The positions of the motor end plates were determined by means of multichannel-electromyography. The positions that allow longest stimulation periods are located close to the points where the nerves enter the muscle. Stimulation at the position of the motor end plates does not result in stimulation periods above average. Locations initially causing strong muscle contractions are not necessarily identical to the ones allowing long stimulation periods. The animal model identified the stimulation points for minimal possible muscle fatigue stimulation as being located close to the points of entrance of the nerve into the muscle. Stimulation causing an initially strong contraction response is no indication of optimal location of the stimulation electrode in terms of chronic stimulation. The array electrode of this study could be interesting as a stimulation electrode for a larynx pacemaker.

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Acknowledgments

The author would like to thank Ira Sanders for the advice concerning the use of Sihler’s staining, and Ms. Johanna Malcher for language assistance.

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Authors and Affiliations

  1. Division for Motor Research, Pathophysiology and Biomechanics, Department for Trauma-, Hand- and Reconstructive Surgery, University Hospital, Friedrich-Schiller-University Jena, Erfurter Str. 35, 07740, Jena, Germany

    Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann & Hans-Christoph Scholle

  2. Institute of Systematic Zoology and Evolutionary Biology with Phyletic Museum, Friedrich-Schiller-University Jena, Jena, Germany

    Dirk Arnold

  3. Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany

    Orlando Guntinas-Lichius

Authors
  1. Bernd Faenger
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  2. Dirk Arnold
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  3. Nikolaus P. Schumann
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  4. Orlando Guntinas-Lichius
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  5. Hans-Christoph Scholle
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Corresponding author

Correspondence to Bernd Faenger.

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Faenger, B., Arnold, D., Schumann, N.P. et al. Method to test the long-term stability of functional electrical stimulation via multichannel electrodes (e.g., applicable for laryngeal pacing) and to define best points for stimulation: in vivo animal analysis. Eur Arch Otorhinolaryngol 274, 327–336 (2017). https://doi.org/10.1007/s00405-016-4202-3

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  • DOI: https://doi.org/10.1007/s00405-016-4202-3

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