Skip to main content

Advertisement

SpringerLink
Log in

Ameloblastoma: a clinical review and trends in management

  • Review Article
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Cusack JW (1827) Report of the amputations of the lower jaw. Dubliln Hop Rec 4:1–38

    Google Scholar 

  2. Ivery RH, Churchill HR (1930) The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin. Am Assoc Dent Sch Trans 7:240–245

    Google Scholar 

  3. Brazis PW, Miller NR, Lee AG, Holliday MJ (1995) Neuro-ophthalmologic aspects of ameloblastoma. Skull Base Surg 5(4):233–244

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z, Mock D, Nikai H (1998) Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86(6):707–714

    Article  CAS  PubMed  Google Scholar 

  5. Mosadomi A (1975) Odontogenic tumors in an African population. Analysis of twenty-nine cases seen over a 5-year period. Oral Surg Oral Med Oral Pathol 40(4):502–521

    Article  CAS  PubMed  Google Scholar 

  6. Barnes L, Everson JW, Reichart P, Sidransky D (eds) (2005) Pathology and genetics of head and neck tumours. IARC Press, Lyon

  7. Daley TD, Wysocki GP, Pringle GA (1994) Relative incidence of odontogenic tumors and oral and jaw cysts in a Canadian population. Oral Surg Oral Med Oral Pathol 77(3):276–280

    Article  CAS  PubMed  Google Scholar 

  8. Regezi JA, Kerr DA, Courtney RM (1978) Odontogenic tumors: analysis of 706 cases. J Oral Surg 36(10):771–778

    CAS  PubMed  Google Scholar 

  9. Larsson A, Almeren H (1978) Ameloblastoma of the jaws. An analysis of a consecutive series of all cases reported to the Swedish Cancer Registry during 1958–1971. Acta Pathol Microbiol Scand A 86A(5):337–349

    CAS  PubMed  Google Scholar 

  10. Wenig BM (2007) Atlas of head and neck pathology, 2nd edn. Elsevier Saunders

  11. Becelli R, Carboni A, Cerulli G, Perugini M, Iannetti G (2002) Mandibular ameloblastoma: analysis of surgical treatment carried out in 60 patients between 1977 and 1998. J Craniofac Surg 13(3):395–400

    Article  CAS  PubMed  Google Scholar 

  12. Olaitan AA, Adeola DS, Adekeye EO (1993) Ameloblastoma: clinical features and management of 315 cases from Kaduna, Nigeria. J Craniomaxillofac Surg 21(8):351–355

    Article  CAS  PubMed  Google Scholar 

  13. Schafer DR, Thompson LD, Smith BC, Wenig BM (1998) Primary ameloblastoma of the sinonasal tract: a clinicopathologic study of 24 cases. Cancer 82(4):667–674

    Article  CAS  PubMed  Google Scholar 

  14. Reichart PA, Philipsen HP, Sonner S (1995) Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol 31B(2):86–99

    Article  CAS  PubMed  Google Scholar 

  15. Stanley HR, Diehl DL (1965) Ameloblastoma potential of follicular cysts. Oral Surg Oral Med Oral Pathol 20:260–268

    Article  CAS  PubMed  Google Scholar 

  16. Slootweg PJ, Muller H (1984) Malignant ameloblastoma or ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol 57(2):168–176

    Article  CAS  PubMed  Google Scholar 

  17. Singer SR, Mupparapu M, Philipone E (2009) Cone beam computed tomography findings in a case of plexiform ameloblastoma. Quintessence Int 40(8):627–630

    PubMed  Google Scholar 

  18. Underhill TE, Katz JO, Pope TL Jr, Dunlap CL (1992) Radiologic findings of diseases involving the maxilla and mandible. AJR Am J Roentgenol 159(2):345–350. doi:10.2214/ajr.159.2.1632353

    Article  CAS  PubMed  Google Scholar 

  19. Carlson ER (1996) Pathologic facial asymmetries. Atlas Oral Maxillofac Surg Clin N Am 4(1):19–35

    CAS  Google Scholar 

  20. Cohen MA, Hertzanu Y, Mendelsohn DB (1985) Computed tomography in the diagnosis and treatment of mandibular ameloblastoma: report of cases. J Oral Maxillofac Surg 43(10):796–800

    Article  CAS  PubMed  Google Scholar 

  21. Fujita M, Matsuzaki H, Yanagi Y, Hara M, Katase N, Hisatomi M, Unetsubo T, Konouchi H, Nagatsuka H, Asaumi JI (2013) Diagnostic value of MRI for odontogenic tumours. Dentomaxillofac Radiol 42(5):20120265. doi:10.1259/dmfr.20120265

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Kawai T, Kishino M, Hiranuma H, Sasai T, Ishida T (1999) A unique case of desmoplastic ameloblastoma of the mandible: report of a case and brief review of the English language literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87(2):258–263

    Article  CAS  PubMed  Google Scholar 

  23. Dunfee BL, Sakai O, Pistey R, Gohel A (2006) Radiologic and pathologic characteristics of benign and malignant lesions of the mandible. Radiographics 26(6):1751–1768. doi:10.1148/rg.266055189

    Article  PubMed  Google Scholar 

  24. Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM (2000) Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127(8):1671–1679

    CAS  PubMed  Google Scholar 

  25. Ritchie A (1990) Boyd’s text book of pathology, 9th edn. Lea and Febiger, UK

    Google Scholar 

  26. Bhasker S (1981) Synopsis of oral pathlogy, 6th edn. The CV Mosby, USA

    Google Scholar 

  27. Gardner DG, Corio RL (1984) Plexiform unicystic ameloblastoma. A variant of ameloblastoma with a low-recurrence rate after enucleation. Cancer 53(8):1730–1735

    Article  CAS  PubMed  Google Scholar 

  28. Muller H, Slootweg PJ (1985) The ameloblastoma, the controversial approach to therapy. J Maxillofac Surg 13(2):79–84

    Article  CAS  PubMed  Google Scholar 

  29. Rosenstein T, Pogrel MA, Smith RA, Regezi JA (2001) Cystic ameloblastoma—behavior and treatment of 21 cases. J Oral Maxillofac Surg 59(11):1311–1316. doi:10.1053/joms.2001.27522

    Article  CAS  PubMed  Google Scholar 

  30. Robinson L, Martinez MG (1977) Unicystic ameloblastoma: a prognostically distinct entity. Cancer 40(5):2278–2285

    Article  CAS  PubMed  Google Scholar 

  31. Ackermann GL, Altini M, Shear M (1988) The unicystic ameloblastoma: a clinicopathological study of 57 cases. J Oral Pathol 17(9–10):541–546

    Article  CAS  PubMed  Google Scholar 

  32. Carlson ER, Marx RE (2006) The ameloblastoma: primary, curative surgical management. J Oral Maxillofac Surg 64(3):484–494. doi:10.1016/j.joms.2005.11.032

    Article  PubMed  Google Scholar 

  33. Waldron CA, el-Mofty SK (1987) A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant. Oral Surg Oral Med Oral Pathol 63(4):441–451

    Article  CAS  PubMed  Google Scholar 

  34. Philipsen HP, Reichart PA, Takata T (2001) Desmoplastic ameloblastoma (including “hybrid” lesion of ameloblastoma). Biological profile based on 100 cases from the literature and own files. Oral Oncol 37(5):455–460

    Article  CAS  PubMed  Google Scholar 

  35. Keszler A, Paparella ML, Dominguez FV (1996) Desmoplastic and non-desmoplastic ameloblastoma: a comparative clinicopathological analysis. Oral Dis 2(3):228–231

    Article  CAS  PubMed  Google Scholar 

  36. Takata T, Miyauchi M, Ito H, Ogawa I, Kudo Y, Zhao M, Sato S, Takekoshi T, Nikai H, Tanimoto K (1999) Clinical and histopathological analyses of desmoplastic ameloblastoma. Pathol Res Pract 195(10):669–675. doi:10.1016/S0344-0338(99)80057-0

    Article  CAS  PubMed  Google Scholar 

  37. Buchner A, Merrell PW, Carpenter WM (2006) Relative frequency of peripheral odontogenic tumors: a study of 45 new cases and comparison with studies from the literature. J Oral Pathol Med 35(7):385–391. doi:10.1111/j.1600-0714.2006.00437.x

    Article  PubMed  Google Scholar 

  38. Fernandes AM, Duarte EC, Pimenta FJ, Souza LN, Santos VR, Mesquita RA, de Aguiar MC (2005) Odontogenic tumors: a study of 340 cases in a Brazilian population. J Oral Pathol Medicine 34(10):583–587. doi:10.1111/j.1600-0714.2005.00357.x

    Article  Google Scholar 

  39. LeCorn DW, Bhattacharyya I, Vertucci FJ (2006) Peripheral ameloblastoma: a case report and review of the literature. J Endod 32(2):152–154. doi:10.1016/j.joen.2005.10.028

    Article  PubMed  Google Scholar 

  40. Eliasson AH, Moser RJ 3rd, Tenholder MF (1989) Diagnosis and treatment of metastatic ameloblastoma. South Med J 82(9):1165–1168

    Article  CAS  PubMed  Google Scholar 

  41. Elzay RP (1982) Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol 54(3):299–303

    Article  CAS  PubMed  Google Scholar 

  42. Kruse AL, Zwahlen RA, Gratz KW (2009) New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol 1:31. doi:10.1186/1758-3284-1-31

    Article  PubMed  PubMed Central  Google Scholar 

  43. Ward BB, Edlund S, Sciubba J, Helman JI (2007) Ameloblastic carcinoma (primary type) isolated to the anterior maxilla: case report with review of the literature. J Oral Maxillofac Surg 65(9):1800–1803. doi:10.1016/j.joms.2006.06.265

    Article  PubMed  Google Scholar 

  44. Dhir K, Sciubba J, Tufano RP (2003) Ameloblastic carcinoma of the maxilla. Oral Oncol 39(7):736–741

    Article  PubMed  Google Scholar 

  45. Henderson JM, Sonnet JR, Schlesinger C, Ord RA (1999) Pulmonary metastasis of ameloblastoma: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88(2):170–176

    Article  CAS  PubMed  Google Scholar 

  46. Bruce RA, Jackson IT (1991) Ameloblastic carcinoma. Report of an aggressive case and review of the literature. J Craniomaxillofac Surg 19(6):267–271

    Article  CAS  PubMed  Google Scholar 

  47. Clay RP, Weiland LH, Jackson IT (1989) Ameloblastoma metastatic to the lung. Ann Plast Surg 22(2):160–162

    Article  CAS  PubMed  Google Scholar 

  48. Kunze E, Donath K, Luhr HG, Engelhardt W, De Vivie R (1985) Biology of metastasizing ameloblastoma. Pathol Res Pract 180(5):526–535. doi:10.1016/S0344-0338(85)80017-0

    Article  CAS  PubMed  Google Scholar 

  49. Laughlin EH (1989) Metastasizing ameloblastoma. Cancer 64(3):776–780

    Article  CAS  PubMed  Google Scholar 

  50. Kahn MA (1989) Ameloblastoma in young persons: a clinicopathologic analysis and etiologic investigation. Oral Surg Oral Med Oral Pathol 67(6):706–715

    Article  CAS  PubMed  Google Scholar 

  51. Correnti M, Rossi M, Avila M, Perrone M, Rivera H (2010) Human papillomavirus in ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(3):e20–e24. doi:10.1016/j.tripleo.2010.04.030

    Article  PubMed  Google Scholar 

  52. Kahn MA (1992) Demonstration of human papillomavirus DNA in a peripheral ameloblastoma by in situ hybridization. Hum Pathol 23(2):188–191

    Article  CAS  PubMed  Google Scholar 

  53. Namin AK, Azad TM, Eslami B, Sarkarat F, Shahrokhi M, Kashanian F (2003) A study of the relationship between ameloblastoma and human papilloma virus. J Oral Maxillofac Surg 61(4):467–470. doi:10.1053/joms.2003.50011

    Article  PubMed  Google Scholar 

  54. Sand L, Jalouli J, Larsson PA, Magnusson B, Hirsch JM (2000) Presence of human papilloma viruses in intraosseous ameloblastoma. J Oral Maxillofac Surg 58(10):1129–1134. doi:10.1053/joms.2000.9573

    Article  CAS  PubMed  Google Scholar 

  55. Migaldi M, Pecorari M, Rossi G, Maiorana A, Bettelli S, Tamassia MG, De Gaetani C, Leocata P, Portolani M (2005) Does HPV play a role in the etiopathogenesis of ameloblastoma? An immunohistochemical, in situ hybridization and polymerase chain reaction study of 18 cases using laser capture microdissection. Mod Pathol 18(2):283–289. doi:10.1038/modpathol.3800241

    Article  CAS  PubMed  Google Scholar 

  56. Kurppa KJ, Caton J, Morgan PR, Ristimaki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K (2014) High frequency of BRAF V600E mutations in ameloblastoma. J Pathol 232(5):492–498. doi:10.1002/path.4317

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Sweeney RT, McClary AC, Myers BR, Biscocho J, Neahring L, Kwei KA, Qu K, Gong X, Ng T, Jones CD, Varma S, Odegaard JI, Sugiyama T, Koyota S, Rubin BP, Troxell ML, Pelham RJ, Zehnder JL, Beachy PA, Pollack JR, West RB (2014) Identification of recurrent SMO and BRAF mutations in ameloblastomas. Nat Genet 46(7):722–725. doi:10.1038/ng.2986

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Brown NA, Rolland DC, McHugh JB, Weigelin HC, Zhao LL, Lim MS, Elenitoba-Johnson KS, Betz BL (2014) Activating FGFR2-RAS-BRAF mutations in ameloblastoma. Clin Cancer Res. doi:10.1158/1078-0432.CCR-14-1069

    Google Scholar 

  59. Cobourne MT, Hardcastle Z, Sharpe PT (2001) Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ. J Dent Res 80(11):1974–1979

    Article  CAS  PubMed  Google Scholar 

  60. Heikinheimo K, Jee KJ, Niini T, Aalto Y, Happonen RP, Leivo I, Knuutila S (2002) Gene expression profiling of ameloblastoma and human tooth germ by means of a cDNA microarray. J Dent Res 81(8):525–530

    Article  CAS  PubMed  Google Scholar 

  61. Daya-Grosjean L, Couve-Privat S (2005) Sonic hedgehog signaling in basal cell carcinomas. Cancer Lett 225(2):181–192. doi:10.1016/j.canlet.2004.10.003

    Article  CAS  PubMed  Google Scholar 

  62. Dassule HR, Lewis P, Bei M, Maas R, McMahon AP (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127(22):4775–4785

    CAS  PubMed  Google Scholar 

  63. Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK, Cooper MK, Gaffield W, Westphal H, Beachy PA, Dlugosz AA (1999) Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol 205(1):1–9. doi:10.1006/dbio.1998.9103

    Article  CAS  PubMed  Google Scholar 

  64. Gorlin RJ, Goltz RW (1960) Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rib. A syndrome. N Engl J Med 262:908–912. doi:10.1056/NEJM196005052621803

    Article  CAS  PubMed  Google Scholar 

  65. Ally MS, Tang JY, Joseph T, Thompson B, Lindgren J, Raphael MA, Ulerio G, Chanana AM, Mackay-Wiggan JM, Bickers DR, Epstein EH Jr (2014) The use of vismodegib to shrink keratocystic odontogenic tumors in patients with basal cell nevus syndrome. JAMA Dermatol 150(5):542–545. doi:10.1001/jamadermatol.2013.7444

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  66. Farias LC, Gomes CC, Brito JA, Galvao CF, Diniz MG, de Castro WH, Bernardes Vde F, De Marco LA, Gomez RS (2012) Loss of heterozygosity of the PTCH gene in ameloblastoma. Hum Pathol 43(8):1229–1233. doi:10.1016/j.humpath.2011.08.026

    Article  CAS  PubMed  Google Scholar 

  67. Carvalhais J, Aguiar M, Araujo V, Araujo N, Gomez R (1999) p53 and MDM2 expression in odontogenic cysts and tumours. Oral Dis 5(3):218–222

    Article  CAS  PubMed  Google Scholar 

  68. Appel T, Gath R, Wernert N, Martini M, Berge S (2004) Molecular biological and immunohistochemical analysis of tp53 in human ameloblastomas. Mund Kiefer Gesichtschir 8(3):167–172. doi:10.1007/s10006-004-0539-7

    Article  CAS  PubMed  Google Scholar 

  69. Shibata T, Nakata D, Chiba I, Yamashita T, Abiko Y, Tada M, Moriuchi T (2002) Detection of TP53 mutation in ameloblastoma by the use of a yeast functional assay. J Oral Pathol Med 31(9):534–538

    Article  CAS  PubMed  Google Scholar 

  70. Sehdev MK, Huvos AG, Strong EW, Gerold FP, Willis GW (1974) Proceedings: Ameloblastoma of maxilla and mandible. Cancer 33(2):324–333

    Article  CAS  PubMed  Google Scholar 

  71. Shatkin S, Hoffmeister FS (1965) Ameloblastoma: a rational approach to therapy. Oral Surg Oral Med Oral Pathol 20(4):421–435

    Article  CAS  PubMed  Google Scholar 

  72. Mehlisch DR, Dahlin DC, Masson JK (1972) Ameloblastoma: a clinicopathologic report. J Oral Surg 30(1):9–22

    CAS  PubMed  Google Scholar 

  73. Ueno S, Mushimoto K, Shirasu R (1989) Prognostic evaluation of ameloblastoma based on histologic and radiographic typing. J Oral Maxillofac Surg 47(1):11–15

    Article  CAS  PubMed  Google Scholar 

  74. Eckardt AM, Kokemuller H, Flemming P, Schultze A (2009) Recurrent ameloblastoma following osseous reconstruction—a review of twenty years. J Craniomaxillofac Surg 37(1):36–41. doi:10.1016/j.jcms.2008.07.009

    Article  PubMed  Google Scholar 

  75. Nakamura N, Higuchi Y, Mitsuyasu T, Sandra F, Ohishi M (2002) Comparison of long-term results between different approaches to ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93(1):13–20

    Article  PubMed  Google Scholar 

  76. Curi MM, Dib LL, Pinto DS (1997) Management of solid ameloblastoma of the jaws with liquid nitrogen spray cryosurgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84(4):339–344

    Article  CAS  PubMed  Google Scholar 

  77. Pogrel MA (1993) The use of liquid nitrogen cryotherapy in the management of locally aggressive bone lesions. J Oral Maxillofac Surg 51(3):269–273

    Article  CAS  PubMed  Google Scholar 

  78. Lau SL, Samman N (2006) Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review. Int J Oral Maxillofac Surg 35(8):681–690. doi:10.1016/j.ijom.2006.02.016

    Article  CAS  PubMed  Google Scholar 

  79. Chapelle KA, Stoelinga PJ, de Wilde PC, Brouns JJ, Voorsmit RA (2004) Rational approach to diagnosis and treatment of ameloblastomas and odontogenic keratocysts. Br J Oral Maxillofac Surg 42(5):381–390. doi:10.1016/j.bjoms.2004.04.005

    Article  PubMed  Google Scholar 

  80. Huffman GG, Thatcher JW (1974) Ameloblastoma—the conservative surgical approach to treatment: report of four cases. J Oral Surg 32(11):850–854

    CAS  PubMed  Google Scholar 

  81. Sham E, Leong J, Maher R, Schenberg M, Leung M, Mansour AK (2009) Mandibular ameloblastoma: clinical experience and literature review. ANZ J Surg 79(10):739–744. doi:10.1111/j.1445-2197.2009.05061.x

    Article  PubMed  Google Scholar 

  82. Gardner DG, Pecak AM (1980) The treatment of ameloblastoma based on pathologic and anatomic principles. Cancer 46(11):2514–2519

    Article  CAS  PubMed  Google Scholar 

  83. Williams TP (1993) Management of ameloblastoma: a changing perspective. J Oral Maxillofac Surg 51(10):1064–1070

    Article  CAS  PubMed  Google Scholar 

  84. Becelli R, Morello R, Renzi G, Matarazzo G, Dominici C (2011) Treatment of recurrent mandibular ameloblastoma with segmental resection and revascularized fibula free flap. J Craniofac Surg 22(3):1163–1165. doi:10.1097/SCS.0b013e318210bc34

    Article  PubMed  Google Scholar 

  85. Vayvada H, Mola F, Menderes A, Yilmaz M (2006) Surgical management of ameloblastoma in the mandible: segmental mandibulectomy and immediate reconstruction with free fibula or deep circumflex iliac artery flap (evaluation of the long-term esthetic and functional results). J Oral Maxillofac Surg 64(10):1532–1539. doi:10.1016/j.joms.2005.11.065

    Article  PubMed  Google Scholar 

  86. Urken ML, Buchbinder D, Weinberg H, Vickery C, Sheiner A, Parker R, Schaefer J, Som P, Shapiro A, Lawson W et al (1991) Functional evaluation following microvascular oromandibular reconstruction of the oral cancer patient: a comparative study of reconstructed and nonreconstructed patients. Laryngoscope 101(9):935–950. doi:10.1288/00005537-199109000-00004

    Article  CAS  PubMed  Google Scholar 

  87. Urken ML, Buchbinder D, Costantino PD, Sinha U, Okay D, Lawson W, Biller HF (1998) Oromandibular reconstruction using microvascular composite flaps: report of 210 cases. Arch Otolaryngol Head Neck Surg 124(1):46–55

    Article  CAS  PubMed  Google Scholar 

  88. Carlson ER (2000) Ameloblastoma. In: Symposium on odontogenic tumors, AAOMS 82nd annual meeting and scientific sessions, San Francisco, CA, September 23, 2000

  89. Zwahlen RA, Gratz KW (2002) Maxillary ameloblastomas: a review of the literature and of a 15-year database. J Craniomaxillofac Surg 30(5):273–279

    Article  PubMed  Google Scholar 

  90. Ndukwe KC, Adebiyi EK, Ugboko VI, Adeyemo WL, Ajayi FO, Ladeinde AL, Okojie VN, Ajike SO, Olasoji HO (2010) Ameloblastic carcinoma: a multicenter Nigerian study. J Oral Maxillofac Surg 68(9):2111–2114. doi:10.1016/j.joms.2009.09.028

    Article  PubMed  Google Scholar 

  91. Gardner DG (1984) A pathologist’s approach to the treatment of ameloblastoma. J Oral Maxillofac Surg 42(3):161–166

    Article  CAS  PubMed  Google Scholar 

  92. Black CC, Addante RR, Mohila CA (2010) Intraosseous ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(5):585–592. doi:10.1016/j.tripleo.2010.02.040

    Article  PubMed  Google Scholar 

  93. Marx RE, Smith BH, Smith BR, Fridrich KL (1993) Swelling of the retromolar region and cheek associated with limited opening. J Oral Maxillofac Surg 51(3):304–309

    Article  CAS  PubMed  Google Scholar 

  94. Forrest LA, Schuller DE, Karanfilov B, Lucas JG (1997) Update on intraoperative analysis of mandibular margins. Am J Otolaryngol 18(6):396–399

    Article  CAS  PubMed  Google Scholar 

  95. Gephardt GN, Zarbo RJ (1996) Interinstitutional comparison of frozen section consultations. A college of American Pathologists Q-Probes study of 90,538 cases in 461 institutions. Arch Pathol Lab Med 120(9):804–809

    CAS  PubMed  Google Scholar 

  96. Ueno S, Nakamura S, Mushimoto K, Shirasu R (1986) A clinicopathologic study of ameloblastoma. J Oral Maxillofac Surg 44(5):361–365

    Article  CAS  PubMed  Google Scholar 

  97. Gold L, Upton GW, Marx RE (1991) Standardized surgical terminology for the excision of lesions in bone: an argument for accuracy in reporting. J Oral Maxillofac Surg 49(11):1214–1217

    Article  CAS  PubMed  Google Scholar 

  98. Winther C, Graem N (2011) Accuracy of frozen section diagnosis: a retrospective analysis of 4785 cases. APMIS 119(4–5):259–262. doi:10.1111/j.1600-0463.2011.02725.x

    Article  PubMed  Google Scholar 

  99. Guthrie D, Peacock ZS, Sadow P, Dodson TB, August M (2012) Preoperative incisional and intraoperative frozen section biopsy techniques have comparable accuracy in the diagnosis of benign intraosseous jaw pathology. J Oral Maxillofac Surg 70(11):2566–2572. doi:10.1016/j.joms.2011.11.023

    Article  PubMed  Google Scholar 

  100. Zemann W, Feichtinger M, Kowatsch E, Karcher H (2007) Extensive ameloblastoma of the jaws: surgical management and immediate reconstruction using microvascular flaps. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(2):190–196. doi:10.1016/j.tripleo.2006.05.004

    Article  PubMed  Google Scholar 

  101. Pogrel MA, Podlesh S, Anthony JP, Alexander J (1997) A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects. J Oral Maxillofac Surg 55(11):1200–1206

    Article  CAS  PubMed  Google Scholar 

  102. Chana JS, Chang YM, Wei FC, Shen YF, Chan CP, Lin HN, Tsai CY, Jeng SF (2004) Segmental mandibulectomy and immediate free fibula osteoseptocutaneous flap reconstruction with endosteal implants: an ideal treatment method for mandibular ameloblastoma. Plast Reconstr Surg 113(1):80–87. doi:10.1097/01.PRS.0000097719.69616.29

    Article  PubMed  Google Scholar 

  103. Foster RD, Anthony JP, Sharma A, Pogrel MA (1999) Vascularized bone flaps versus nonvascularized bone grafts for mandibular reconstruction: an outcome analysis of primary bony union and endosseous implant success. Head Neck 21(1):66–71

    Article  CAS  PubMed  Google Scholar 

  104. Hidalgo DA, Pusic AL (2002) Free-flap mandibular reconstruction: a 10-year follow-up study. Plastic and reconstructive surgery 110(2):438–449

    Article  PubMed  Google Scholar 

  105. Nastri AL, Wiesenfeld D, Radden BG, Eveson J, Scully C (1995) Maxillary ameloblastoma: a retrospective study of 13 cases. Br J Oral Maxillofac Surg 33(1):28–32

    Article  CAS  PubMed  Google Scholar 

  106. Miyamoto CT, Brady LW, Markoe A, Salinger D (1991) Ameloblastoma of the jaw. Treatment with radiation therapy and a case report. Am J Clin Oncol 14(3):225–230

    Article  CAS  PubMed  Google Scholar 

  107. Pinsolle J, Michelet V, Coustal B, Siberchicot F, Michelet FX (1995) Treatment of ameloblastoma of the jaws. Arch Otolaryngol Head Neck Surg 121(9):994–996

    Article  CAS  PubMed  Google Scholar 

  108. Ueda M, Kaneda T (1991) Combined chemotherapy and radiotherapy for advanced maxillary ameloblastoma. A case report. J Craniomaxillofac surg 19(6):272–274

    Article  CAS  PubMed  Google Scholar 

  109. Atkinson CH, Harwood AR, Cummings BJ (1984) Ameloblastoma of the jaw. A reappraisal of the role of megavoltage irradiation. Cancer 53(4):869–873

    Article  CAS  PubMed  Google Scholar 

  110. Gardner DG (1988) Radiotherapy in the treatment of ameloblastoma. Int J Oral Maxillofac Surg 17(3):201–205

    Article  CAS  PubMed  Google Scholar 

  111. Huvos AG, Woodard HQ, Cahan WG, Higinbotham NL, Stewart FW, Butler A, Bretsky SS (1985) Postradiation osteogenic sarcoma of bone and soft tissues. A clinicopathologic study of 66 patients. Cancer 55(6):1244–1255

    Article  CAS  PubMed  Google Scholar 

  112. Philip M, Morris C, Werning J, Mendenhall W (2005) Radiotherapy in the treatment of ameloblastoma and ameloblastic carcinoma. Hong Kong J Radiol 8(3):157

    Google Scholar 

  113. Cizmecy O, Aslan A, Onel D, Demiryont M (2004) Ameloblastic carcinoma ex ameloblastoma of the mandible: case report. Otolaryngol Head Neck Surg 130(5):633–634. doi:10.1016/j.otohns.2003.11.012

    Article  PubMed  Google Scholar 

  114. Cox DP, Muller S, Carlson GW, Murray D (2000) Ameloblastic carcinoma ex ameloblastoma of the mandible with malignancy-associated hypercalcemia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90(6):716–722. doi:10.1067/moe.2000.109076

    Article  CAS  PubMed  Google Scholar 

  115. Akrish S, Buchner A, Shoshani Y, Vered M, Dayan D (2007) Ameloblastic carcinoma: report of a new case, literature review, and comparison to ameloblastoma. J Oral Maxillofac Surg 65(4):777–783. doi:10.1016/j.joms.2005.11.116

    Article  PubMed  Google Scholar 

  116. Corio RL, Goldblatt LI, Edwards PA, Hartman KS (1987) Ameloblastic carcinoma: a clinicopathologic study and assessment of eight cases. Oral Surg Oral Med Oral Pathol 64(5):570–576

    Article  CAS  PubMed  Google Scholar 

  117. Naik V, Kale AD (2007) Ameloblastic carcinoma: a case report. Quintessence Int 38(10):873–879

    PubMed  Google Scholar 

  118. Datta R, Winston JS, Diaz-Reyes G, Loree TR, Myers L, Kuriakose MA, Rigual NR, Hicks WL Jr (2003) Ameloblastic carcinoma: report of an aggressive case with multiple bony metastases. Am J Otolaryngol 24(1):64–69. doi:10.1053/ajot.2003.15

    Article  PubMed  Google Scholar 

  119. Goldenberg D, Sciubba J, Koch W, Tufano RP (2004) Malignant odontogenic tumors: a 22-year experience. Laryngoscope 114(10):1770–1774. doi:10.1097/00005537-200410000-00018

    Article  PubMed  Google Scholar 

  120. Dorner L, Sear AJ, Smith GT (1988) A case of ameloblastic carcinoma with pulmonary metastases. Br J Oral Maxillofac Surg 26(6):503–510

    Article  CAS  PubMed  Google Scholar 

  121. McClatchey KD, Sullivan MJ, Paugh DR (1989) Peripheral ameloblastic carcinoma: a case report of a rare neoplasm. J Otolaryngol 18(3):109–111

    CAS  PubMed  Google Scholar 

  122. Lee L, Maxymiw WG, Wood RE (1990) Ameloblastic carcinoma of the maxilla metastatic to the mandible. Case report. J Craniomaxillofac surg 18(6):247–250

    Article  CAS  PubMed  Google Scholar 

  123. Nagai N, Takeshita N, Nagatsuka H, Inoue M, Nishijima K, Nojima T, Yamasaki M, Hoh C (1991) Ameloblastic carcinoma: case report and review. J Oral Pathol Med 20(9):460–463

    Article  CAS  PubMed  Google Scholar 

  124. Gandy SR, Keller EE, Unni KK (1992) Ameloblastic carcinoma: report of two cases. J Oral Maxillofac Surg 50(10):1097–1102

    Article  CAS  PubMed  Google Scholar 

  125. Ingram EA, Evans ML, Zitsch RP 3rd (1996) Fine-needle aspiration cytology of ameloblastic carcinoma of the maxilla: a rare tumor. Diagn Cytopathol 14(3):249–252. doi:10.1002/(SICI)1097-0339(199604)14:3<249:AID-DC10>3.0.CO;2-L

    Article  CAS  PubMed  Google Scholar 

  126. Lau SK, Tideman H, Wu PC (1998) Ameloblastic carcinoma of the jaws. A report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85(1):78–81

    Article  CAS  PubMed  Google Scholar 

  127. Infante-Cossio P, Hernandez-Guisado JM, Fernandez-Machin P, Garcia-Perla A, Rollon-Mayordomo A, Gutierrez-Perez JL (1998) Ameloblastic carcinoma of the maxilla: a report of 3 cases. J Craniomaxillofac Surg 26(3):159–162

    Article  CAS  PubMed  Google Scholar 

  128. Simko EJ, Brannon RB, Eibling DE (1998) Ameloblastic carcinoma of the mandible. Head Neck 20(7):654–659

    Article  CAS  PubMed  Google Scholar 

  129. Sastre J, Munoz M, Naval L, Adrados M (2002) Ameloblastic carcinoma of the maxilla: report of a case. J Oral Maxillofac Surg 60(1):102–104

    Article  PubMed  Google Scholar 

  130. Avon SL, McComb J, Clokie C (2003) Ameloblastic carcinoma: case report and literature review. J Can Dent Assoc 69(9):573–576

    PubMed  Google Scholar 

  131. Oginni FO, Ugboko VI, Owotade JF, Adebiyi KE (2003) Ameloblastic carcinoma of the jaws. A report of three Nigerian cases. Odontostomatol Trop 26(104):19–22

    CAS  PubMed  Google Scholar 

  132. Carinci F, Palmieri A, Delaiti G, Rubini C, Fioroni M, Martinelli M, Pezzetti F, Scapoli L, Piattelli A (2004) Expression profiling of ameloblastic carcinoma. J Craniofac Surg 15(2):264–269

    Article  PubMed  Google Scholar 

  133. Uzum N, Akyol G, Asal K, Koybasioglu A (2005) Ameloblastic carcinoma containing melanocyte and melanin pigment in the mandible: a case report and review of the literature. J Oral Pathol Med 34(10):618–620. doi:10.1111/j.1600-0714.2005.00306.x

    Article  CAS  PubMed  Google Scholar 

  134. Ozlugedik S, Ozcan M, Basturk O, Deren O, Kaptanoglu E, Adanali G, Unal A (2005) Ameloblastic carcinoma arising from anterior skull base. Skull base 15(4):269–272. doi:10.1055/s-2005-918621

    Article  PubMed  PubMed Central  Google Scholar 

  135. Suomalainen A, Hietanen J, Robinson S, Peltola JS (2006) Ameloblastic carcinoma of the mandible resembling odontogenic cyst in a panoramic radiograph. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(5):638–642. doi:10.1016/j.tripleo.2005.07.033

    Article  PubMed  Google Scholar 

  136. Miyake T, Tanaka Y, Kato K, Tanaka M, Sato Y, Ijiri R, Inayama Y, Ito Y, Aoki S, Kawabe R, Tohnai I (2006) Gene mutation analysis and immunohistochemical study of beta-catenin in odontogenic tumors. Pathol Int 56(12):732–737. doi:10.1111/j.1440-1827.2006.02039.x

    Article  CAS  PubMed  Google Scholar 

  137. Hall JM, Weathers DR, Unni KK (2007) Ameloblastic carcinoma: an analysis of 14 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(6):799–807. doi:10.1016/j.tripleo.2006.11.048

    Article  PubMed  Google Scholar 

  138. Benlyazid A, Lacroix-Triki M, Aziza R, Gomez-Brouchet A, Guichard M, Sarini J (2007) Ameloblastic carcinoma of the maxilla: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104(6):e17–e24. doi:10.1016/j.tripleo.2007.05.026

    Article  PubMed  Google Scholar 

  139. Yazici N, Karagoz B, Varan A, Yilmaz T, Ozturk A, Usubutun A, Buyukpamukcu M (2008) Maxillary ameloblastic carcinoma in a child. Pediatr Blood Cancer 50(1):175–176. doi:10.1002/pbc.20889

    Article  PubMed  Google Scholar 

  140. Gardner DG (1995) Canine acanthomatous epulis. The only common spontaneous ameloblastoma in animals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79(5):612–615

    Article  CAS  PubMed  Google Scholar 

  141. Gall JA, Sartiano GP, Shreiner DP (1975) Ameloblastoma of the mandible with pulmonary metastasis. Oncology 32(3–4):118–126

    CAS  PubMed  Google Scholar 

  142. Ramadas K, Jose C, Subhashini J, Chandi SM, Viswanathan FR (1990) Pulmonary metastases from ameloblastoma of the mandible treated with cisplatin, adriamycin, and cyclophosphamide. Cancer 66(7):1475–1479

    Article  CAS  PubMed  Google Scholar 

  143. Grünwald V, Le Blanc S, Karstens JH, Weihkopf T, Kuske M, Ganser A, Schoffski P (2001) Metastatic malignant ameloblastoma responding to chemotherapy with paclitaxel and carboplatin. Ann Oncol 12(10):1489–1491

    Article  PubMed  Google Scholar 

  144. Campbell D, Jeffrey RR, Wallis F, Hulks G, Kerr KM (2003) Metastatic pulmonary ameloblastoma. An unusual case. Br J Oral Maxillofac Surg 41(3):194–196

    Article  CAS  PubMed  Google Scholar 

  145. Amzerin M, Fadoukhair Z, Belbaraka R, Iraqui M, Boutayeb S, M’Rabti H, Kebdani T, Hassouni K, Benjaafar N, El Gueddari BK, Errihani H (2011) Metastatic ameloblastoma responding to combination chemotherapy: case report and review of the literature. J Med Case Rep 5:491. doi:10.1186/1752-1947-5-491

    Article  PubMed  PubMed Central  Google Scholar 

  146. Van Dam SD, Unni KK, Keller EE (2010) Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg 68(12):2962–2974. doi:10.1016/j.joms.2010.05.084

    Article  PubMed  Google Scholar 

  147. Ciment LM, Ciment AJ (2002) Malignant ameloblastoma metastatic to the lungs 29 years after primary resection: a case report. Chest 121(4):1359–1361

    Article  PubMed  Google Scholar 

  148. Jackson IT, Callan PP, Forte RA (1996) An anatomical classification of maxillary ameloblastoma as an aid to surgical treatment. J Craniomaxillofac Surg 24(4):230–236

    Article  CAS  PubMed  Google Scholar 

  149. Daramola JO, Ajagbe HA, Oluwasanmi JO (1980) Recurrent ameloblastoma of the jaws—a review of 22 cases. Plast Reconstr Surg 65(5):577–579

    Article  CAS  PubMed  Google Scholar 

  150. Frantz V, Stix L (1932) Adamantinoma: a case of fifty-one years’duration. Arch Surg 25(5):890–897

    Article  Google Scholar 

  151. Nakasato S, Okamura S, Kudo K, Takeda Y (1991) Gigantic ameloblastoma associated with secondary hypoproteinemia. J Oral Maxillofac Surg 49(7):764–767

    Article  CAS  PubMed  Google Scholar 

  152. Inoue N, Shimojyo M, Iwai H, Ohtsuki H, Yasumizu R, Shintaku M, Taniguchi N, Inada M, Arika T, Morita S et al (1988) Malignant ameloblastoma with pulmonary metastasis and hypercalcemia. Report of an autopsy case and review of the literature. Am J Clin Pathol 90(4):474–481

    Article  CAS  PubMed  Google Scholar 

  153. Harada K, Suda S, Kayano T, Nagura H, Enomoto S (1989) Ameloblastoma with metastasis to the lung and associated hypercalcemia. J Oral Maxillofac Surg 47(10):1083–1087

    Article  CAS  PubMed  Google Scholar 

  154. Ramon Y, Mozes M, Buchner A (1964) A fatal case of Ameloblastoma (Adamantinoma). Br J Plast Surg 17:320–324

    Article  CAS  PubMed  Google Scholar 

  155. Bredenkamp JK, Zimmerman MC, Mickel RA (1989) Maxillary ameloblastoma. A potentially lethal neoplasm. Arch Otolaryngol Head Neck Surg 115(1):99–104

    Article  CAS  PubMed  Google Scholar 

  156. Lin Y, He JF, Li ZY, Liu JH (2013) Ameloblastoma with varied sites of metastasis: report of two cases and literature review. J Craniomaxillofac Surg. doi:10.1016/j.jcms.2013.10.010

    Google Scholar 

  157. Nielsen TO, West RB (2010) Translating gene expression into clinical care: sarcomas as a paradigm. J Clin Oncol 28(10):1796–1805. doi:10.1200/JCO.2009.26.1917

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank Norm Cyr for his assistance in preparing the figures presented in the review.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Author information

Authors and Affiliations

  1. Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, 801 Welch Rd., MC 5739, Stanford, CA, 94305, USA

    Christopher F. Holsinger, John Sunwoo & Davud Sirjani

  2. Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA

    Andrew C. McClary, Robert B. West & Jonathan R. Pollack

  3. Division of Oncology, Department of Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA

    A. Dimitrios Colevas

  4. Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA

    Ashley C. McClary

  5. Department of Radiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA

    Nancy J. Fischbein

Authors
  1. Andrew C. McClary
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert B. West
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ashley C. McClary
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jonathan R. Pollack
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nancy J. Fischbein
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Christopher F. Holsinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. John Sunwoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. Dimitrios Colevas
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Davud Sirjani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Andrew C. McClary or Davud Sirjani.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

McClary, A.C., West, R.B., McClary, A.C. et al. Ameloblastoma: a clinical review and trends in management. Eur Arch Otorhinolaryngol 273, 1649–1661 (2016). https://doi.org/10.1007/s00405-015-3631-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-015-3631-8

Keywords

Search

Navigation