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A pooled analysis of the IL-10-1082 A/G polymorphism and the nasopharyngeal carcinoma susceptibility

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Abstract

It has been reported that IL-10-1082 A/G polymorphism might influence the transcription and secretion of IL10 and tumor development. While many studies have been conducted to investigate the association between IL-10-1082 A/G polymorphism and risk of nasopharyngeal carcinoma (NPC) in various populations, the results of these studies are still controversial. We aimed to explore this relationship through a cumulative meta-analysis. A search of the literature was performed using the Cochrane Library, PubMed, and EMBASE databases. The odds ratio (OR) and corresponding 95 % confidence interval (CI) were calculated to assess this possible association. Six studies were included in the study. The meta-analysis reveals a significant effect in the allelic model (G vs. A: OR 1.516, 95 % CI 1.077–2.133, P heterogeneity = 0.003), dominant model (AG + GG vs. AA: OR = 1.770, 95 % CI 1.415–2.212, P heterogeneity = 0.169), and co-dominant model (AG vs. AA: OR = 1.747, 95 % CI 1.377–2.216, P heterogeneity = 0.491). Similarly, in the stratified analyses, significant effects were reported in studies of Asian populations. Our meta-analysis results suggest that the IL-10-1082 A/G variant is associated with increased risk of NPC in Asian populations.

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Conflict of interest

There was no financial support for this project to disclose, and the authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China

    Liping Ma, Shan Li, Yu Lu, Xiaolian Zhang, Jiangyang Zhao & Xue Qin

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  1. Liping Ma
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  2. Shan Li
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  3. Yu Lu
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  4. Xiaolian Zhang
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  5. Jiangyang Zhao
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  6. Xue Qin
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Correspondence to Xue Qin.

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Supplementary Table 1 Scale for quality assessment. (DOC 37 kb)

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Ma, L., Li, S., Lu, Y. et al. A pooled analysis of the IL-10-1082 A/G polymorphism and the nasopharyngeal carcinoma susceptibility. Eur Arch Otorhinolaryngol 273, 819–825 (2016). https://doi.org/10.1007/s00405-014-3465-9

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  • DOI: https://doi.org/10.1007/s00405-014-3465-9

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