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Etiopathogenesis of otosclerosis

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Abstract

The objectives of our study was to review our current knowledge of the etiopathogenesis of otosclerotic bone remodeling including genetics, viral infection, autoimmunity and inflammation and to discuss disease pathogenesis with relevance to pharmacotherapy. Relevant publications on the etiopathogenesis, molecular biology, genetics and histopathology of otosclerosis from 1984 to 2009 were analyzed. Otosclerosis is a bone remodeling disorder of the human otic capsule; however, the etiopathogenesis remains unclear. Genetic predisposition, disturbed bone metabolism, persistent measles virus infection, autoimmunity, and hormonal and environmental factors also may play contributing roles in the pathogenesis of otosclerosis. Since diagnosis of otosclerosis is still based on histopathological examination of the removed stapes footplate, systemic prospective studies based on comprehensive histopathological and molecular biological analysis are necessary to obtain further information on the background of the disease.

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Acknowledgments

This work was supported by the grants from the Hungarian Scientific Research Fund (OTKA PD75371) and Mecenatúra Fund of Debrecen University (DE OEC Mec 17/2008).

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  1. Department of Otolaryngology Head and Neck Surgery, Medical and Health Science Center, University of Debrecen, Nagyerdei Krt. 98, Debrecen, 4032, Hungary

    Tamás Karosi & István Sziklai

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Correspondence to Tamás Karosi.

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Karosi, T., Sziklai, I. Etiopathogenesis of otosclerosis. Eur Arch Otorhinolaryngol 267, 1337–1349 (2010). https://doi.org/10.1007/s00405-010-1292-1

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