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Effect of topical mitomycin C for antrostomy in rabbit with sinusitis

  • Rhinology
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Abstract

The aim of this study is to evaluate if mitomycin C (MMC), applied topically at the site of maxillary antrostomy in experimentally inflamed maxillary sinuses, may reduce postoperative ostial stenosis without any harmful effect. Twenty-four rabbits with experimentally induced maxillary sinusitis underwent maxillary antrostomy bilaterally. MMC at a concentration of 0.4 or 1 mg/ml was applied at the site of antrostomy on the right whilst the antrostomy site on the left served as the control. Half of each MMC concentration group of animals were killed after 3 weeks, and the remaining half after 6 weeks. For every rabbit, the areas of antrostomies were measured and mucosal specimens around the ostia were obtained for microscopic evaluation at the time of antrostomy and killing. Within each MMC concentration group, MMC-treated antrostomies were significantly wider than those of the controls (P < 0.05), even after 6 weeks. However, comparison of the areas of MMC-treated antrostomies between the two MMC concentration groups did not show any significant difference (P > 0.05). No systemic side effect or permanent mucosal damage was detected. These results suggest that postoperative topical MMC at a concentration of 0.4 mg/ml can be used to prolong the patency of maxillary antrostomy in an inflammed sinus.

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Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Dongguk University, Goyang, South Korea

    Seok-Won Park

  2. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University Hospital, 640 Daesa-Dong, Jung-Gu, Daejeon, 301-040, South Korea

    Bon Seok Koo, Yong Ho Park & Ki Sang Rha

  3. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Yanbian University, Yanji, China

    Yong De Jin

Authors
  1. Seok-Won Park
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  2. Bon Seok Koo
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  3. Yong Ho Park
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  4. Yong De Jin
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  5. Ki Sang Rha
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Correspondence to Ki Sang Rha.

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Park, SW., Koo, B.S., Park, Y.H. et al. Effect of topical mitomycin C for antrostomy in rabbit with sinusitis. Eur Arch Otorhinolaryngol 263, 917–923 (2006). https://doi.org/10.1007/s00405-006-0083-1

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  • DOI: https://doi.org/10.1007/s00405-006-0083-1

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