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Presence of endometrioma decreased blastocyst formation rate but not impair Assisted Reproductive Technology (ART) outcome

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

This study aims to assess the impact of endometrioma on patients who undergo ART treatment due to endometriosis.

Methods

A retrospective study was conducted on women ≤ 40 years of age who underwent ART treatment at an academic medical center between January 2014 and December 2020. Two-hundred-and-eight women had received IVF/ICSI treatment due to endometriosis and there were 89 patients presence of endometrioma. Patients were further divided into primary endometrioma, recurrent endometrioma and those having received cystectomy for endometrioma prior to IVF/ICSI. The control group included 624 infertile women without endometriosis.

Results

In the endometrioma subgroup (B) the blastocyst formation rate was significantly lower when compared with the endometriosis (A) and control groups (C). The cumulative live birth rates (CLBRs) (60.5% versus 49.4% versus 56.9%, p = 0.194 in A versus B, p = 0.406 in A versus C, p = 0.878 in B versus C) were comparable. Multiple logistic regression analysis revealed that female age, total FSH dose and blastocyst formation rate were the significant variables in predicting CLBR (OR 0.89, CI 0.80–0.99, p < 0.025, OR 0.68 CI 0.53–0.88, p = 0.003 and OR 30.04, CI 9.93–90.9, p < 0.001, respectively). The CLBRs were comparable at 47.1%, 60% and 57.9% in the primary endometrioma, s/p cystectomy and recurrent endometrioma group.

Conclusion

Although the blastocyst formation rate was lower in the endometrioma group, CLBR was not worse than those who were in the endometriosis or control group. Cystectomy for endometrioma did not alter IVF/ICSI outcomes if the ovarian reserve was comparable. Recurrent endometrioma did not worsen IVF/ICSI outcomes than primary endometrioma.

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Availability of data and materials

All data generated and analyzed during this study are included in this published article and its supplementary information files.

Data availability

Data of the study are available and can be provided upon request.

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Funding

No funding was received for conducting this study.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology and Women’s Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun Dist, Taichung City, Taiwan

    Jui-Chun Chang, Yu-Chiao Yi, Ya-Fang Chen, Hwa-Fen Guu, Hsiao-Fan Kung, Li-Yu Chen, Shih-Ting Chuan & Ming-Jer Chen

  2. School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan

    Yu-Chiao Yi & Ming-Jer Chen

  3. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan

    Yu-Chiao Yi

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  1. Jui-Chun Chang
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Contributions

J-CC: Protocol/project development, Data Collection, Manuscript writing. M-JC: Protocol/project development, manuscript revision. H-FK: prepared the figures and tables. Y-CY: prepared the figures and tables. H-FG: Data collection or management. L-YC: Data collection or management. Y-FC: Data analysis. S-TC: Data analysis. All authors reviewed the manuscript.

Corresponding author

Correspondence to Ming-Jer Chen.

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The authors have no relevant financial or non-financial interests to disclose.

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Institutional Review Board, TCVGH, No. CE21306B. Date of approval: August 30, 2021.

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Chang, JC., Yi, YC., Chen, YF. et al. Presence of endometrioma decreased blastocyst formation rate but not impair Assisted Reproductive Technology (ART) outcome. Arch Gynecol Obstet 307, 2011–2020 (2023). https://doi.org/10.1007/s00404-023-07036-2

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