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Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age

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Abstract

Objective

To assess the influence of maternal age on the incidence of early-onset preeclampsia requiring delivery before 34 weeks of gestation in pregnancies obtained after oocyte donation.

Methods

We carried out a prospective cohort analysis of 431 single and twin pregnancies, admitted to 3 Tertiary Referral Hospital in Northern Italy between 2008 and 2017. The rate of early-onset PE was calculated and stratified according to maternal age (from 30 to 49 years). A reference population of 11,197 single pregnancies collected prospectively at the first trimester of pregnancy in the same geographic area of Italy and in same hospitals was used to calculate the expected incidence of early-onset PE.

Results

In women who delivered after 24 weeks of gestation, the rate of early-onset PE was much higher in oocyte-donation pregnancies, reaching 6.7% (29/431), than the expected rate of 0.5% of the cohort of reference. The mean early PE rate was 4.1% (10/242) in singletons and 10.1% (19/189) in twin pregnancies. According to maternal age, the rate of early PE was 1.16% and 3.12% at 30 years, and 4.98% and 13.14% at 49 years in single and twin pregnancies obtained after oocyte donation, respectively.

Conclusion

Pregnancies obtained after oocyte donation delivering after 24 weeks had a higher risk of early-onset PE requiring delivery before 34 weeks of gestation, than the general population. The risk is directly correlated with the increase of maternal age and is also higher in twin pregnancies.

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Author information

Authors and Affiliations

  1. Department of Surgical Sciences, OIRM S. Anna Hospital, University of Turin, Turin, EU, Italy

    Bianca Masturzo, Chiara Germano & Gianluca Gennarelli

  2. Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, EU, Italy

    Daniela Di Martino & Enrico Ferrazzi

  3. Department of Obstetrics and Gynecology, University of Brescia, Brescia, EU, Italy

    Federico Prefumo

  4. Gynecology and Obstetrics Department, IRCCS San Raffaele Hospital, Vita-Salute University, Milan, EU, Italy

    Paolo Cavoretto

  5. Gynecology and Obstetrics Department, Maggiore University Hospital, Parma, EU, Italy

    Enrica Roletti

  6. Department of Woman, Mother and Neonate, Buzzi Children’s Hospital, University of Milan, Milan, Eu, Italy

    Elisa Bottazzoli & Federica Fusè

  7. Department of Obstetrics and Gynecology, Sant’Anna University Hospital, Cona, Ferrara, EU, Italy

    Danila Morano

  8. Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, EU, Italy

    Antonio Farina

Authors
  1. Bianca Masturzo
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Contributions

BM: protocol/project development, data collection, manuscript writing. DDM: protocol/project development. FP: data collection. PC: data collection. CG: protocol/project development, data collection, manuscript writing. GG: Protocol/project development, data collection. ER: protocol/project development, data collection. EB: data collection. FF: data collection. EF: protocol/project development. DM: protocol/project development, manuscript writing. AF: protocol/project development, data collection, manuscript writing, data analysis.

Corresponding author

Correspondence to Antonio Farina.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The committee for this study is Professor Antonio Farina.

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Informed consent was obtained from all individual participants included in the study.

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Masturzo, B., Di Martino, D., Prefumo, F. et al. Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age. Arch Gynecol Obstet 300, 861–867 (2019). https://doi.org/10.1007/s00404-019-05291-w

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  • DOI: https://doi.org/10.1007/s00404-019-05291-w

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