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Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

Placental site trophoblastic tumor (PSTT) is a form of gestational trophoblastic disease that originates from the implantation of an intermediate trophoblast. It was described for the first time by Von F. Marchand in 1895 as belonging to chorioepithelioma sui generis, a pathological condition with many variations and a progressive degree of malignancy.

Methods

We have conducted a literature review in MEDLINE about epidemiology, etiopathogenesis and clinical features of PSTT. Moreover, a case that occurred in our institution was reported.

Results

Our research has highlighted that existing published data about PSTT are not uniform. The number of cases described in the literature has updated and the clinical features of selected “case series” of patients diagnosed with PSTT were showed. The etiopathogenesis was discussed. It was noted that current prognostic factors still allow important information regarding PSTT to be obtained, albeit fragmentary.

Conclusions

The lack of uniformity in data collection seen so far has limited full knowledge of PSTT. For this reason, we suggest a model (PSTT model) that collects and unifies PSTT evidence as this would be useful to identify worldwide precise prognostic factors, which are still lacking. When PSTT is diagnosed, the proper procedure seems to be total hysterectomy, with sampling of pelvic lymph nodes and ovarian conservation. For advanced-stage diseases, (stage III and IV) a combination of surgery and polychemotherapy is suggested.

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Authors and Affiliations

  1. Department of Biomedical and Dental Sciences and Morpho-Functional Images, 1st floor Biologic Tower, A.O.U. Policlinic “G. Martino”, University of Messina, Via Consolare Valeria, 98125, Messina, Italy

    Giuseppe Santoro & Antonio Micali

  2. Department of Human Pathology in Adulthood and Childhood “ G. Barresi”, A.O.U. “G. Martino”, University of Messina, Via Consolare Valeria, 98125, Messina, Italy

    Antonio Simone Laganà, Valeria Barresi, Valentina Giacobbe & Vittorio Palmara

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  1. Giuseppe Santoro
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  2. Antonio Simone Laganà
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  3. Antonio Micali
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  4. Valeria Barresi
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  5. Valentina Giacobbe
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  6. Vittorio Palmara
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Correspondence to Giuseppe Santoro.

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We declare that for this type of study formal consent is not required, this article does not contain any studies with human participants or animals performed by any of the authors and Informed consent from the patient was obtained.

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Santoro, G., Laganà, A.S., Micali, A. et al. Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside. Arch Gynecol Obstet 295, 173–187 (2017). https://doi.org/10.1007/s00404-016-4182-y

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