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Macrophage colony-stimulating factor (M-CSF) in first trimester maternal serum: correlation with pathologic pregnancy outcome

  • Maternal-Fetal Medicine
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Abstract

Purpose

To determine correlations between macrophage colony-stimulating factor (MCSF) levels in maternal blood during first trimester screening with respect to normal and pathological pregnancies.

Methods

This was a prospective single centre study. First trimester screening was performed according to FMF London certificates. Nuchal translucency, PAPP-A and free β-HCG were obtained as well as M-CSF serum levels in maternal blood. Fetal karyotyping was achieved by chorionic villi sampling.

Results

125 patients were enrolled in this study. 21 pregnancies had confirmed aberrant karyotypes. Trisomy 21 cases showed significantly elevated M-CSF levels of 270 ± 91 pg/ml (p = 0.032), whereas cases of trisomy 13 (183 ± 68 pg/ml) and trisomy 18 (143 ± 40 pg/ml) had low M-CSF levels. Furthermore M-CSF levels tended to be low in preterm deliveries, placental insufficiency and nicotine consumption. In cases with gestational diabetes M-CSF tended to be elevated. Furthermore we found a positive correlation between high free β-human chorionic gonadotropin (hcg) and MCSF values. There was no correlation between pregnancy associated plasma protein (PAPP-A) and M-CSF.

Conclusions

M-CSF is a cytokine promoting placental growth and differentiation. M-CSF is known to be involved in the process of implantation in pregnancy. The role of M-CSF with respect to disturbed pregnancy outcomes such as placental insufficiency in normal or aberrant karyotypes, for example, is yet subject to further research.

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References

  1. Tsakonas DP et al (1995) Changes in maternal plasma macrophage-colony stimulating factor levels during normal pregnancy. Clin Lab Haematol 17(1):57–59

    Article  CAS  PubMed  Google Scholar 

  2. Katano K et al (1997) Low serum M-CSF levels are associated with unexplained recurrent abortion. Am J Reprod Immunol 38(1):1–5

    Article  CAS  PubMed  Google Scholar 

  3. Hayashi M et al (1996) High blood levels of macrophage colony-stimulating factor in preeclampsia. Blood 88(12):4426–4428

    CAS  PubMed  Google Scholar 

  4. Wald N et al (1992) First trimester concentrations of pregnancy associated plasma protein A and placental protein 14 in Down’s syndrome. BMJ 305(6844):28

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Wald NJ, Hackshaw AK (2000) Advances in antenatal screening for Down syndrome. Baillieres Best Pract Res Clin Obstet Gynaecol 14(4):563–580

    Article  CAS  PubMed  Google Scholar 

  6. Staboulidou I et al (2009) First-trimester uterine artery Doppler and serum pregnancy-associated plasma protein-a in preeclampsia and chromosomal defects. Fetal Diagn Ther 25(3):336–339

    Article  PubMed  Google Scholar 

  7. Spencer K et al (2006) First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of impending fetal death. Ultrasound Obstet Gynecol 28(5):637–643

    Article  CAS  PubMed  Google Scholar 

  8. Bersinger NA, Noble P, Nicolaides KH (2003) First-trimester maternal serum PAPP-A, SP1 and M-CSF levels in normal and trisomic twin pregnancies. Prenat Diagn 23(2):157–162

    Article  CAS  PubMed  Google Scholar 

  9. Piccinni MP et al (2001) Defective production of LIF, M-CSF and Th2-type cytokines by T cells at fetomaternal interface is associated with pregnancy loss. J Reprod Immunol 52(1–2):35–43

    Article  CAS  PubMed  Google Scholar 

  10. Garcia-Lloret MI et al (1994) Demonstration of functional cytokine-placental interactions: CSF-1 and GM-CSF stimulate human cytotrophoblast differentiation and peptide hormone secretion. Exp Cell Res 214(1):46–54

    Article  CAS  PubMed  Google Scholar 

  11. Saito S et al (1993) Cytokine production by CD16-CD56bright natural killer cells in the human early pregnancy decidua. Int Immunol 5(5):559–563

    Article  CAS  PubMed  Google Scholar 

  12. Hayashi M, Ohkura T (2002) Elevated levels of serum macrophage colony-stimulating factor in normotensive pregnancies complicated by intrauterine fetal growth restriction. Exp Hematol 30(5):388–393

    Article  CAS  PubMed  Google Scholar 

  13. Keith JC Jr et al (2000) Maternal serum levels of macrophage colony-stimulating factor are associated with adverse pregnancy outcome. Eur J Obstet Gynecol Reprod Biol 89(1):19–25

    Article  CAS  PubMed  Google Scholar 

  14. Huang SJ et al (2008) Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua. J Pathol 214(3):328–336

    Article  CAS  PubMed  Google Scholar 

  15. Wright A et al (2004) Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway. Am J Med Genet A 130A(4):354–364

    Article  PubMed  Google Scholar 

  16. Wu ZM et al (2012) Pro-inflammatory cytokine-stimulated first trimester decidual cells enhance macrophage-induced apoptosis of extravillous trophoblasts. Placenta 33(3):188–194

    Article  PubMed  PubMed Central  Google Scholar 

  17. Praloran V et al (1994) Elevation of serum M-CSF concentrations during pregnancy and ovarian hyperstimulation. Br J Haematol 86(3):675–677

    Article  CAS  PubMed  Google Scholar 

  18. Pollard JW et al (1987) Apparent role of the macrophage growth factor, CSF-1, in placental development. Nature 330(6147):484–486

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Kiel and Christian-Albrechts-University Kiel, Arnold-Heller-Straße 3, 24105, Kiel, Germany

    Christel Eckmann-Scholz, Christina Wilke, Ibrahim Alkatout & Ali Salmassi

  2. Department of Oral and Maxillofacial Surgery, Universtity Hospital Schleswig-Holstein, Campus Kiel and Christian-Albrechts-University Kiel, Arnold-Heller-Straße 3, 24105, Kiel, Germany

    Yahya Acil

Authors
  1. Christel Eckmann-Scholz
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  2. Christina Wilke
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  3. Yahya Acil
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  4. Ibrahim Alkatout
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  5. Ali Salmassi
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Corresponding author

Correspondence to Christel Eckmann-Scholz.

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All authors declare no conflict of interest.

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Eckmann-Scholz, C., Wilke, C., Acil, Y. et al. Macrophage colony-stimulating factor (M-CSF) in first trimester maternal serum: correlation with pathologic pregnancy outcome. Arch Gynecol Obstet 293, 1213–1217 (2016). https://doi.org/10.1007/s00404-015-3931-7

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  • DOI: https://doi.org/10.1007/s00404-015-3931-7

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